Protein Alignment Rif1 and Rif1

DIOPT Version :9

• Sequence 1: NP_725497.1
• Gene: Rif1 / 246445
• FlyBaseID: FBgn0050085
• Length: 1416
• Species: Drosophila melanogaster
• Sequence 2: XP_038962180.1
• Gene: Rif1 / 295602
• RGDID: 1562474
• Length: 2424
• Species: Rattus norvegicus
• Alignment Length: 1759
• Identity: 342/1759 - (19%)
• Similarity: 582/1759 - (33%)
• Gaps: 588/1759 - (33%)

  Fly    62 WLGDILPLMFDADRKIQDCAVAALAEAL---------VALDVSVIHSAKCWPQIRSEFVDK-YTI 116
            |...::||:..:.:|:......||...:         :||....:.:.|...:::..|:.| .|.
  Rat   184 WAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIALITEHLMTTKLISELQKLFMSKNETY 248

  Fly   117 IIGEMRDAKNSNWHKIWTLLVQIMDEDLLRGCVYINKFLALVELGFRNPDNGVRSEAFLCWRVLI 181
            ::            |:|.|.|:::.:.|.|...:||..|.|.|||||:....::..||:.|:.||
  Rat   249 VL------------KLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGTPMIKKIAFIAWKSLI 301

  Fly   182 KIFAAY-DELTSAKRLRLLLIPLRTSQSRSSHVSGIKLRVWWYLLSCLDHELPKSFDSAVEHFL- 244
            ..||.. |.|.|||||:||:.||.:...|:..::..||.||||||..|..:||.:|:......:
  Rat   302 DNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQ 366

  Fly   245 --------AFMLGGGPRNLATGLA--------HNYQTARELALPCLVAL----WGVESSEPLQRL 289
                    |...|...|....||:        .:|.|.|       |.|    .|:.:...:|.|
  Rat   367 STISVDSSASPQGSSSRGSTPGLSPLTPGNKGASYGTPR-------VNLGSNIGGMATIPSIQLL 424

  Fly   290 MRELRLETLVQPS-------------------PLMSVEVFQQHWKPLLAAAVSGLKLLTENDATE 335
            ..|:.|..|:.|.                   ||:|...|...:...|..||....:....||::
  Rat   425 GLEMMLHFLLGPEVLSFAKQHKIVLSLEPLEHPLISSPSFFSKYAHTLITAVHDSFVAVGKDASD 489

  Fly   336 AEQLLLQLLVRNLCLAMFRLAVAPFNVACCSEIEKILQAEDNSGGRVVRALFNTIAADNLVM--- 397
            |   ::..:.:.|             ::....:.:....::.||..|:..|..::  :|:|.
  Rat   490 A---VVSAIWKEL-------------ISLVKSVTESGNRKERSGSEVLTLLLKSL--ENIVKSEV 536

  Fly   398 ------------------ERVSGSD-----HLDVLEA-----YLKLVLKS-------KTEVPAAI 427
                              ::|.||.     ::|:|..     .::|:|.:       :.|.....
  Rat   537 FPVSKTLVLMEITVKGLPQKVLGSPAYQVANMDILNGTPALFLIQLILNNNLLECGVEDEKFFLN 601

  Fly   428 LQRSIACI---------FAVDRIEANNQNEFRMLGSFAELLMQANDEEDFEGFAFKLQVWRQVSQ 483
            |:..:.|:         |:...:...|||..::          ||.|..:       ::|..:..
  Rat   602 LETLVGCVLSGPTSPLAFSDSVLTVINQNAKQL----------ANKEHLW-------RMWSMIVS 649

  Fly   484 ALSNYL-------RNNALEYRVAHNAS--------------------------LLDTW--LLWPL 513
            .|::.:       :.:|||    ||.|                          ||.||  |....
  Rat   650 PLTDVIHQTNEVNQGDALE----HNFSAIYGALTLPINHIFSTPTFPTGTMKTLLKTWSELYRAF 710

  Fly   514 QTLAAFAGRRASN------------------SFDASFCDQWRQ----LVNAGQNAPGRKKFLTDL 556
            ...||.......|                  ..|..|.|:...    :|:....:|...|:...:
  Rat   711 ARCAAVVATAEENLCCEELSSKIMCSLEDEALSDLLFLDRISHVVVVMVDCIDFSPYNIKYQPKI 775

  Fly   557 KA--TLTDLLKSKDEPL--FAELFDAYVTSLIKFGLCKEAPLYKD---------------VFG-- 600
            |:  ..:|..:.|.|||  .|.||...|..:..|........|.|               :||
  Rat   776 KSPQRSSDWSRKKKEPLGKLASLFKLIVRIIDSFHTLSLKETYSDTLLAIGNSIISMLSNIFGHI 840

  Fly   601 ----LLQTIF-----------------EQPSSQKTLEACLNTLRNLVVELRQNELMVVFDS---- 640
                :::.||                 |.|....:|...|..|...:|...|...:..:||
  Rat   841 SLSSMIREIFTTFTRPLALLYENSKLDEVPKVYTSLNNKLEKLLGEIVACLQFNYLGAYDSELLG 905

  Fly   641 -LKPTL------------SSGIQCWNKMKCEGGFL---EEWK----------------------- 666
             |.|.|            ......||....:...|   ||.|
  Rat   906 QLSPLLCIIFLHKNKQIRKQSAVLWNATFAKATALIYPEELKPILRQAKQKILLLLPGLENVEMM 970

  Fly   667 --------------------RGIQEK---------------------FRKLPMKTMANQLK---- 686
                                .|::.|                     ..||.:.:.:.:||
  Rat   971 DESSGPYSDATENSQLNVKISGMERKSSGKRDSILAHTKEKKENVRLSAKLKLDSSSPKLKNGKL 1035

  Fly   687 -ELFKADDLFVIIPSVWSLNPEK-------LTDRQKERF-AEKSDIPALYNDMSQSQDSASIKPW 742
             |..|:.| ||.||      ||.       ||:.|||.. .::.|||||||::..|||:
  Rat  1036 LEEEKSTD-FVFIP------PEGKETKARILTEHQKEVLKTKRCDIPALYNNLDASQDT------ 1087

  Fly   743 TPKKVVIAKSKQGELALTGKDDNGEVIDITASEESEKEPVRVDVVTPIRKKPGRKSQAQKELEAA 807
                                        :.:::.|::|.:....:|   :||...::..|| |..
  Rat  1088 ----------------------------LFSAQFSQEESMESLTLT---EKPKEDAKIIKE-EQM 1120

  Fly   808 ARAASLAEEPPKRQTRTRAAQKET-----EQVAQPQP--------AFEPQLRSPKKLPPSPVVQS 859
            ..|..:.::.|:..|..:..:|.:     ..||:..|        |.:..|.|.|
  Rat  1121 ESAIFIPQDAPENCTIDQHPEKASLPNYGGSVAETNPETLSTGFDARKEMLISSK---------- 1175

  Fly   860 TAAAVKQAKVAKPTPVVVIAQSEDLFPEVAAEPEPQPE-----PVKKPDPVPETTQLTPPDVPLE 919
                 ..|:.:..:...|::.|.......:..|:|...     .::|.|. .||...:|.  ||.
  Rat  1176 -----MSAECSSSSETTVVSSSSVSNATFSGTPQPTSRRQTFITLEKFDG-SETRPFSPS--PLS 1232

  Fly   920 AVPSTQLPGSSGDPAASAGAVAAGEMSPKKSGTRIYNLSSPPDRKQTN-------------NSSS 971
            .:.||....::.|......       .|:|:..|....|.....|..|             .|.:
  Rat  1233 NLSSTVTVRNNQDNTTKTD-------MPQKARKREVTHSKSDSEKLANGGKKSSRRWSKAEQSVN 1290

  Fly   972 PTLRPKPTGHLTGRGAQLINMIRNKKLDAASGSPYACMSTSRLVHQVTPARA----QDRAEQVST 1032
            ...:|.||..      |......|...|..|.:  .|:|.:   |. .|:.|    :||..:.|.
  Rat  1291 KKFKPSPTSE------QEEQSFENNPPDLLSSA--ECVSEN---HD-HPSEATLEHEDRDPRASV 1343

  Fly  1033 PTSELNELT---------GTDHTSTPIQAPPSKDLLVFSKRLPSPSASPSVSILKR--KLRCESL 1086
            ..:.|.:|.         ....:::|:.|...:.:   ::...:.:|:|:...|:|  :.|.|::
  Rat  1344 ENASLEDLAEGKNVGINKDPKESASPVVAATEQTV---NEGSQAAAAAPNPKALRRSSRRRSEAV 1405

  Fly  1087 ----DDVTLDSPALKRKRVSFHDPPVSVTKEYLRDAEETRSSLKPKRCLLMDKVAQ--TTEMRQA 1145
                |....:|...||:|....:..:|.:..:::|.:      .||:.|..:...|  .||...:
  Rat  1406 ESSGDSQEKESGQQKRERRKEEERTISKSPCHIKDDK------LPKQKLTAEPPIQENLTEKENS 1464

  Fly  1146 LRRR--GRLDSIIEIERFASEQTARTATT----------DKSLDK-------------------- 1178
            |:.|  |...:..||::...:....|.::          |||.:|
  Rat  1465 LQERTLGEPSANAEIDQNRRKPDLETVSSEGGGGTLDNVDKSSEKPLRGRTRYQTRRASQGLISG 1529

  Fly  1179 ------STGEAPEEDA--FTSLKWNDTGNAHNISISEEPVKAMEVESELETAGQDLAIMDPEAAL 1235
                  .:.||.||.:  ..|.||.:. ::.::.|.|:..|.:| :..::||.|   ..|.:|..
  Rat  1530 VENSESDSSEAKEEVSRKKRSGKWKNK-SSDSVDIEEQEEKMVE-DEVMKTASQ---THDGQAVP 1589

  Fly  1236 D--LAVAQLPLESVLQRYFDKSPLKSAGMLAKFLSAQMTANEKLKTN-----------VLET--L 1285
            |  .||||:..:::..|..    |:.:......|...:|..:|.||:           |.|:  .
  Rat  1590 DDINAVAQICEKNINNRVI----LQDSSGSTDSLQVSLTGEDKSKTSKCLDSSLVSLPVPESNLR 1650

  Fly  1286 SENHSKDFLDHAVRENLSSVVCDRLNPTSVLEYVCAKSKISASCRNGLLAQVPEILKS----GPR 1346
            :.|.||.........|:.:.... ::|....:.|..:.|.|...|..         ||    |.:
  Rat  1651 TRNASKRLYKRDTDSNVGASDMS-MSPEKCTQVVECQHKRSRRVRRS---------KSCDCCGEK 1705

  Fly  1347 SDSERLAFVQQLMVQCSPGDDLLLDLIDLLM----RTRRERNNSTST-----------HISKGVV 1396
            |.|:..:|......:.|....|.....||.|    ...:|.|....|           |:....:
  Rat  1706 SQSQEKSFTGLKNTESSAMKSLETKKTDLQMPETAPETQEANEHVETKSVGKQPVVNFHLGLEEI 1770

  Fly  1397 SAVG 1400
            ||.|
  Rat  1771 SATG 1774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rif1	NP_725497.1	Rif1_N	<110..240	CDD:315005	49/131 (37%)
		Atrophin-1	705..>1129	CDD:331285	91/481 (19%)
		GGN	<827..920	CDD:330621	20/110 (18%)
Rif1	XP_038962180.1	Rif1_N	29..361	CDD:403445	58/187 (31%)
		Rif1_CTD_C-II_like	2265..2312	CDD:341312

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007187
OrthoInspector	1	1.000	-	-		oto97301
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22928
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030