DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30075 and FKBP6

DIOPT Version :9

Sequence 1:	NP_725390.1	Gene:	CG30075 / 246437	FlyBaseID:	FBgn0050075	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_003593.3	Gene:	FKBP6 / 8468	HGNCID:	3722	Length:	327	Species:	Homo sapiens

Alignment Length:	169	Identity:	42/169 - (24%)
Similarity:	84/169 - (49%)	Gaps:	20/169 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AKNDKFSTHALLNENDNDQSLSSDEQDDIFFL--IYRKAHTLFQAGKLWMRRMRYHDAQRAFEKA 74
            |::|||.            :||:::||. |.|  :.:.|.|..:.|....|:.|::||:..:::|
Human   146 AESDKFC------------ALSAEQQDQ-FPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRA 197

  Fly    75 ITRLKTCKTSSFEQQCRKKDMLIALFESLMICFNKM-RQSRCVCYVMKELRLLTINNPSALALCQ 138
            :..|:.......||...:...|..|. :|...:.|: |.:..:||   ..:.|.|:..:|.||.:
Human   198 LLLLRRRSAPPEEQHLVEAAKLPVLL-NLSFTYLKLDRPTIALCY---GEQALIIDQKNAKALFR 258

  Fly   139 HGRALSDLGKYHPSRLCYIKALKKRPRDQGIKDKITRIS 177
            .|:|...|.:|..:|...::|.|::|.:..|.:::.:::
Human   259 CGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLA 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30075	NP_725390.1	None
FKBP6	NP_003593.3	FKBP_C	51..140	CDD:306713
		TPR	<164..315	CDD:223533	33/138 (24%)
		TPR 1	171..204		9/32 (28%)
		TPR 2	219..252		9/36 (25%)
		TPR repeat	221..247	CDD:276809	6/29 (21%)
		TPR repeat	252..282	CDD:276809	9/29 (31%)
		TPR 3	253..286		11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10907
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004027
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46674
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.000