DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30075 and FKBP5

DIOPT Version :9

Sequence 1:	NP_725390.1	Gene:	CG30075 / 246437	FlyBaseID:	FBgn0050075	Length:	195	Species:	Drosophila melanogaster
Sequence 2:	NP_001139247.1	Gene:	FKBP5 / 2289	HGNCID:	3721	Length:	457	Species:	Homo sapiens

Alignment Length:	185	Identity:	40/185 - (21%)
Similarity:	79/185 - (42%)	Gaps:	25/185 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KGFKAAKNDKFSTHALLNENDNDQSLSSDEQDDIFFLIYRKAHTLFQAGKLWMRRMRYHDAQRAF 71
            |.|:.||...        |.|..:.|   ||..|   :..|....|:.||       |..|...:
Human   248 KSFEKAKESW--------EMDTKEKL---EQAAI---VKEKGTVYFKGGK-------YMQAVIQY 291

  Fly    72 EKAITRLKTCKTSSFEQQCRKKDMLIALFESLMICFNKMRQ-SRCVCYVMKELRLLTINNPSALA 135
            .|.::.|:.....|.::....:..|:|.|.:|.:|:.|:|: ::.|....|.|.|.:.|..   .
Human   292 GKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEK---G 353

  Fly   136 LCQHGRALSDLGKYHPSRLCYIKALKKRPRDQGIKDKITRISKRITELEDTNQML 190
            |.:.|.|...:.::..::..:.|.|:..|:::..:.:|:...|:..|..:.::.:
Human   354 LYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30075	NP_725390.1	None
FKBP5	NP_001139247.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		FKBP_C	43..135	CDD:278674
		TPR_11	267..347	CDD:290150	21/89 (24%)
		TPR 1	268..301		9/42 (21%)
		TPR repeat	268..296	CDD:276809	8/37 (22%)
		TPR 2	317..350		10/32 (31%)
		TPR_11	319..382	CDD:290150	15/65 (23%)
		TPR	319..350	CDD:197478	9/30 (30%)
		TPR repeat	319..345	CDD:276809	7/25 (28%)
		TPR repeat	350..380	CDD:276809	6/32 (19%)
		TPR 3	351..384		6/35 (17%)
		TPR_1	352..384	CDD:278916	6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..457
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900