DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30059 and ARSL

DIOPT Version :9

Sequence 1:	NP_610872.1	Gene:	CG30059 / 246425	FlyBaseID:	FBgn0260475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001269557.1	Gene:	ARSL / 415	HGNCID:	719	Length:	614	Species:	Homo sapiens

Alignment Length:	528	Identity:	122/528 - (23%)
Similarity:	181/528 - (34%)	Gaps:	179/528 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PLIVLVLACLGNTASEKL----PNILLILSDD---QDVELRGMFPME-HTIEMLGFGGALFHNAY 62
            |.::.||..|..:||..:    |||||:::||   .|:...|...|. ..|:.|...|.......
Human    41 PAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHI 105

  Fly    63 TPSPICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALE----PRALP-------YILQQH 116
            :.:.:|.|:|.:.|||.|.    .|:..||...|     |.|:    ...||       .||::.
Human   106 SAASLCTPSRAAFLTGRYP----VRSGMVSSIGY-----RVLQWTGASGGLPTNETTFAKILKEK 161

  Fly   117 GYNTFFGGKYLNQYWGAG------------DVPKGWNNFYG----LHGNSRYYNYTLRENTGNVH 165
            ||.|...||     |..|            .:..|:::|||    |.|:..  .:.|.|...|:.
Human   162 GYATGLIGK-----WHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCA--RWELSEKRVNLE 219

  Fly   166 YESTYLSDLLRDRA------------------------------------------AD--FLRNA 186
            .:..:|..:|...|                                          ||  .:||.
Human   220 QKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNH 284

  Fly   187 TQSSEPF-FAMVAPPAAHE--PFTPAPRHEGVF--------SHIEALRTPSFNQVKQDKHWLVRA 240
            |.:.:|. |....|....|  .|....:| |.|        .||..:...:|         |.::
Human   285 TITEQPMCFQRTTPLILQEVASFLKRNKH-GPFLLFVSFLHVHIPLITMENF---------LGKS 339

  Fly   241 ARRLPNETINTIDTYFQKRWETLLAVDELVVTLMGVLNDTQSLENTYIIY-TSDNGYHVGQFAQP 304
            ...|..:.:..:|      |    .|..::.||     |.:.|.|:.:|| |||:|   |.....
Human   340 LHGLYGDNVEEMD------W----MVGRILDTL-----DVEGLSNSTLIYFTSDHG---GSLENQ 386

  Fly   305 FDKRQ---------------PYETDINVPLLIRGPGIAPESH-IDTAVSLVDLAPTI--LAWADI 351
            ....|               .:|..|.||.:.|.||:.|... |....||:|:.||:  ||..::
Human   387 LGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEV 451

  Fly   352 DTPSYMDGQSFHELLLNKRRR------VPFFERSLLIEYWGE---GTL-------ATFNPE---- 396
            .....:|||....|||...:.      :.:.||.|....|.:   ||:       ..|.||
Human   452 PQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGA 516

  Fly   397 ------CP 398
                  ||
Human   517 CYGRKVCP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30059	NP_610872.1	G6S	24..467	CDD:293766	116/506 (23%)
CG30059	NP_610872.1	AslA	24..464	CDD:225661	116/506 (23%)
ARSL	NP_001269557.1	ALP_like	62..585	CDD:355016	116/507 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840