DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30059 and Sulf1

DIOPT Version :9

Sequence 1:	NP_610872.1	Gene:	CG30059 / 246425	FlyBaseID:	FBgn0260475	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_008761708.1	Gene:	Sulf1 / 171396	RGDID:	708554	Length:	1117	Species:	Rattus norvegicus

Alignment Length:	807	Identity:	197/807 - (24%)
Similarity:	280/807 - (34%)	Gaps:	354/807 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PNILLILSDDQDVELRGMFPMEHTIEMLGFGGALFHNAYTPSPICCPARTSLLTGMYAHNHGTRN 88
            |||:|:|:|||||||..:..|..|.:::..|||.|.||:..:|:|||:|:|:|||.|.|||....
  Rat    43 PNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFTNAFVTTPMCCPSRSSMLTGKYVHNHNVYT 107

  Fly    89 NSVSGGCYGPHWRRALEPRALPYILQQHGYNTFFGGKYLNQYWGAGDVPKGWNNFYGLHGNSRYY 153
            |:.:  |..|.|:...|||.....|...||.|.|.|||||:|.|: .:|.||..:.||..|||:|
  Rat   108 NNEN--CSSPSWQALHEPRTFAVYLNNTGYRTAFFGKYLNEYNGS-YIPPGWREWLGLIKNSRFY 169

  Fly   154 NYT-----LRENTGNVHYESTYLSDLLRDRAADFLRNATQ--SSEPFFAMVAPPAAHEPFTPAPR 211
            |||     ::|..| ..|...|.:||:.:.:.::.:.:.:  ...|...:::..|.|.|...||:
  Rat   170 NYTVCRNGIKEKHG-FDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQ 233

  Fly   212 HEGVFSHIEALRTPSFNQV-KQDKHWLVR-AARRLP--NETINTIDTYFQKRWETLLAVDELVVT 272
            ...::.:.....|||:|.. ..||||::: ....||  .|..|.:.   :||.:||::||:.|..
  Rat   234 FSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLQ---RKRLQTLMSVDDSVER 295

  Fly   273 LMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVPLLIRGPGIAPESHIDTAVS 337
            |..:|.:|..|.|||||||:|:|||:|||.....|..||:.||.||..||||.|.|.|.:...|.
  Rat   296 LYNMLVETGELGNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSIEPGSIVPQIVL 360

  Fly   338 LVDLAPTILAWADIDTPSYMDGQSFHELL----------LNKRRRV------------------- 373
            .:|||||||..|.:||||.:||:|..:||          .||:.::
  Rat   361 NIDLAPTILDIAGLDTPSDVDGKSVLKLLDLEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEES 425

  Fly   374 ----------PFFE--------------------------------------------------- 377
                      |.:|
  Rat   426 SKNIQQSNHLPKYERVKELCQQARYQTACEQPGQNWQCIEDTSGKLRIHKCKGPSDLLTVRQNAR 490

  Fly   378 -----------------------------------------------------RSLLIEYWGE-- 387
                                                                 |||.:|:.||
  Rat   491 NLYSRGLQDKDKECHCRESGYRPSRSQRKKERQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIY 555

  Fly   388 ----------------------------------------------------------------- 387

  Rat   556 DINLEEEELQVLPPRSVAKRHDEGHQGFGGHQAAAGDFRNEMLADSNSAVGLPTTVRVTHKCFIL 620

  Fly   388 -------------------------------------------GTLATFNP-ECP---------- 398
                                                       |.|....| ||.
  Rat   621 PNDTIHCERELYQSARAWKDHKAYIDKEIEVLQDKIKNLREVRGHLKKRKPEECSCGKQSYYNKE 685

  Fly   399 -------------WPEKDRLAQ------------------------------CT-PAADC----- 414
                         .|.|:..||                              |: |...|
  Rat   686 KGVKRQEKLKSHLHPFKEAAAQEVDSKLQLFKEHRRRKKERKEKKRQRKGEECSLPGLTCFTHDN 750

  Fly   415 -HCQDA--W------------NNTYACLRNIRHREDRIYCEFRDNENFLEAYDLQLDPFQMTNIA 464
             |.|.|  |            ||||.|||.:....:.::|||.  ..|||.:|:..||:|:||..
  Rat   751 NHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFA--TGFLEYFDMNTDPYQLTNTV 813

  Fly   465 YDLLPIERALYS---LRLKNLTQCSGH 488
            :   .|||.:.:   ::|..|..|.|:
  Rat   814 H---TIERGILNQLHIQLMELRSCQGY 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30059	NP_610872.1	G6S	24..467	CDD:293766	190/781 (24%)
CG30059	NP_610872.1	AslA	24..464	CDD:225661	190/778 (24%)
Sulf1	XP_008761708.1	G6S	42..384	CDD:293766	142/347 (41%)
		DUF3740	534..675	CDD:403667	10/140 (7%)
		ALP_like	<767..816	CDD:419962	19/53 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840