DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30047 and ERMP1

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_079172.2	Gene:	ERMP1 / 79956	HGNCID:	23703	Length:	904	Species:	Homo sapiens

Alignment Length:	876	Identity:	268/876 - (30%)
Similarity:	432/876 - (49%)	Gaps:	85/876 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LWVALFYAVVYPLYHRLPDSVLISHESSKPGQFVAERAQRLLYKYDKIGPKVVGSVANEVTTVAF 107
            |.:||:...:..|.......:::...:...|:|.|.:|:..|.....|||:..||..||:.||.:
Human    75 LGLALYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHY 139

  Fly   108 LEEEVENIRAAMRSDLYELQLDVQHPSGAY---MHWQMVNMYQGVTNVVVKISSRSSNSSSYLLV 169
            |.|:::.|.....| |:::.:|||.|:|::   ......:.|..:||||||:..| ..:...:|.
Human   140 LLEQIKLIEVQSNS-LHKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPR-DGAQHAVLA 202

  Fly   170 NSHFDSKPSSPGSGDDGTMVVVMLEVLRQVAISDTPFEHPIVFLFNGAEENPLEASHGFITQHKW 234
            |.||||..:|||:.||.....|||||||.::.|.....|.::|||||||||.|:|||||||||.|
Human   203 NCHFDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPW 267

  Fly   235 AGNCKALINLEVAGSGGRDLLFQSGPNNPWLIKYYYQNAKHPFATTMAEEIFQSGILPSDTDFRI 299
            |...:|.||||.||.||::|:||:||.||||::.|...||||||:.:|:|:|||||:||||||||
Human   268 ASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRI 332

  Fly   300 FRDYGQLPGLDMAQISNGYVYHTIFDNVQAVPIDSLQSSGDNALSLVRAFADAPEMQNPEDHSEG 364
            :||:|.:||:|:|.|.|||:|||.:|....:..||:|.:|||.|::::..|.:..:.....:..|
Human   333 YRDFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHG 397

  Fly   365 HAVFFDYLGLFFVYYTENTGIVLNCCIAVASLVLVVCSLLRMGRESDVSIGRVSIWFAIILVLHV 429
            :.||||.||||.:.|....|.::|..:.:.    ||..|.:...:.....|.....|...|.:.:
Human   398 NMVFFDVLGLFVIAYPSRIGSIINYMVVMG----VVLYLGKKFLQPKHKTGNYKKDFLCGLGITL 458

  Fly   430 LGMILSLGLPLLMAVLFDAGDRSMTYFSNNWLVIGLFIVPAIIGQILPLTL---YYTLKPNDEIS 491
            :....||...|::||......:|::::::.::.:.|:....:...||..||   :|.:..:.:..
Human   459 ISWFTSLVTVLIIAVFISLIGQSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYL 523

  Fly   492 HPNHIHMSLHAHCVLLSLIAIILTAISLRTPYLCMMSLLFYGGALLINLLSTL--------HDRG 548
            ......:||..||..|    :.||...|.:.::..:.:.|       .||:.|        |...
Human   524 GEVFFDISLFVHCCFL----VTLTYQGLCSAFISAVWVAF-------PLLTKLCVHKDFKQHGAQ 577

  Fly   549 YYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFGHGTNPDLLIALICAVGTFFALGFVAPLI 613
            ..::....:...:|:||..||.:....:|.|:|||.|....||:::|.|.|..|.....:....|
Human   578 GKFIAFYLLGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFI 642

  Fly   614 NIFRWPKLALLGLGVVTFIFSMIAVSEVGFPYR---AKTSVMRIHFLHVRRIFYEYDGSVSLSDS 675
            .:.:..|..:|.|.:|..|..::..|...|||.   |.....|:...|:.|.|::.:|:....||
Human   643 YLAKSTKKTMLTLTLVCAITFLLVCSGTFFPYSSNPANPKPKRVFLQHMTRTFHDLEGNAVKRDS 707

  Fly   676 GYY---FDFQDRRLYYPLENTSVNLTGLA-----------STSSECDKYL-MCGVPCFNHRW--- 722
            |.:   ||:                ||::           |..:.|::.. :||.|     |
Human   708 GIWINGFDY----------------TGISHITPHIPEINDSIRAHCEENAPLCGFP-----WYLP 751

  Fly   723 CKTRAKSHWLPREQEVAIPGATSLKLLSK--AVLDSGKVARFEFEISGPPHMSLYIQPLDGVEVE 785
            .....:.:|.....||:.......:|:||  ...||.|:.   ||.:||.|||.|::...|..:.
Human   752 VHFLIRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLT---FEATGPSHMSFYVRAHKGSTLS 813

  Fly   786 DWSFIRNMLDEPDT-YSPPYQIFFAYGADNTPLKFHIDFAKSSGDFSTPTFQLGFAASFVSYDYD 849
            .||....   .|.| ....|.:|:::|...:..:|.|: .:.|.:.......:..||.::|.: |
Human   814 QWSLGNG---TPVTSKGGDYFVFYSHGLQASAWQFWIE-VQVSEEHPEGMVTVAIAAHYLSGE-D 873

  Fly   850 RDAAGLKFISD-FPDFAHVMEWPTLYERYIF 879
            :.:..|..:.: |||:.....|...|:.::|
Human   874 KRSPQLDALKEKFPDWTFPSAWVCTYDLFVF 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	145/309 (47%)
ERMP1	NP_079172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
ERMP1	NP_079172.2	M28_Fxna_like	104..412	CDD:193497	145/309 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145828
Domainoid	1	1.000	238	1.000	Domainoid score	I2299
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1816
Isobase	1	0.950	-	0	Normalized mean entropy	S3525
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm40549
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720