DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30047 and CG10081

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	401/866 - (46%)
Similarity:	592/866 - (68%)	Gaps:	12/866 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VNVLSQQKLRRHR----LPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLISHESSKPGQFVAER 79
            |...|::..|:||    ||||:|...:|.|..||.|||.||::|||:.:.:  |.:..|.|:|||
  Fly    17 VKSYSRKHGRKHRVYFQLPWYFAGGIVLFWALLFIAVVKPLFYRLPEPLTV--EDASKGGFIAER 79

  Fly    80 AQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDVQHPSGAYMHWQMVN 144
            ||..||.::.||.|||||..||..||.||.:|:..|:..::.||:::::|:|:..|||:.|.:||
  Fly    80 AQANLYDFEAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDLFDMEIDLQYAYGAYVKWNLVN 144

  Fly   145 MYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEVLRQVAISDTPFEHP 209
            ||||:.|||||::.:.:.|.:|:||||||||:|:||.:||||.|||.:|||||.::.....||||
  Fly   145 MYQGIQNVVVKLTPKGTTSENYILVNSHFDSQPTSPSTGDDGHMVVSILEVLRVISSRRKSFEHP 209

  Fly   210 IVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGPNNPWLIKYYYQNAK 274
            |:||.||:|||.|:||||||..||||.||||:|||:.||||||:|:||||||||||:|.|...||
  Fly   210 IIFLINGSEENSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQSGPNNPWLVKIYKDGAK 274

  Fly   275 HPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFDNVQAVPIDSLQSSG 339
            |.|:|||||||||:|::||.|||.||.:||.|.|||:.|..||:||||.:|.:..:|..:||::|
  Fly   275 HYFSTTMAEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHTKYDRIDVIPRAALQNTG 339

  Fly   340 DNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCCIAVASLVLVVCSLL 404
            ||.|.||:..::|.|:::...:..|:.:|||.|||:.:.|:.:.|:.||..:|.|:::|:..|||
  Fly   340 DNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKLNYAVAAAAIILIYISLL 404

  Fly   405 RMGRESDVSIGRVSIWFAIILVLHVLGMILSLGLPLLMAVLFDAGDRSMTYFSNNWLVIGLFIVP 469
            |:..:|.||..::...|.::||:.::..:|:|.||||:|...|....|::||:...|:|||:|.|
  Fly   405 RIAEKSSVSSEQILSTFILVLVVQLIAFVLALALPLLVAYGLDKYGLSLSYFATPSLLIGLYICP 469

  Fly   470 AIIGQILPLTLYYTLKPNDEISHPNHIHMSLHAHCVLLSLIAIILTAISLRTPYLCMMSLLFYGG 534
            :::|..||..:|..|...:::|....:.::||.|..:||::.|.:....|||.|:...:|.||..
  Fly   470 SLLGLTLPSYIYLKLANTEKVSFAQQVQLALHGHAAVLSILCIAINYYGLRTTYVITWTLAFYVI 534

  Fly   535 ALLINLLSTLHDRGYYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFGHGTNPDLLIALICA 599
            .|..|||:|||||||.|..:::::|:.||:|..||||.|:::..||:||||..|||||:|..:.|
  Fly   535 PLAFNLLTTLHDRGYSWTGILKIVQVAPFMYNSYLFYCFIVILTPMMGRFGVDTNPDLIIGALTA 599

  Fly   600 VGTFFALGFVAPLINIFRWPKLALLGLGVVTFIFSMIAVS-EVGFPYRAKTSVMRIHFLHVRRIF 663
            :||..::||:..|:|:.|.....|:||..||.....||.| ::|||||.||:|.|:.:|.|||||
  Fly   600 LGTILSMGFLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYRPKTNVQRVPYLQVRRIF 664

  Fly   664 YEYDGSVSLSDSGYYFDFQDRRLYYPLENTSVNLTGLASTSSECDKYLMCGVPCFNHRWCKTRAK 728
            |||||:||..:|||.|:.||||...||..::|:||||.:.:|:|.||:|||:|.::|||.:....
  Fly   665 YEYDGTVSKDESGYLFNLQDRRGLTPLLESNVDLTGLVNMTSDCAKYMMCGMPLYDHRWVEAMET 729

  Fly   729 SHWLPREQEVAIPGATSLKLLSKAVLDSGKVARFEFEISGPPHMSLYIQPLDGVEVEDWSFIRNM 793
            :.||||:..|..|....||.|:|.||..|:..:||||::...|.|::|.|.:.|.:.:|||::..
  Fly   730 TMWLPRKNPVWTPAEPILKQLNKTVLADGQTVQFEFELTTSDHTSIFISPNEDVIISNWSFLKEY 794

  Fly   794 LDEPDTYSPPYQIFFAYGADNTPLKFHIDFAKSSGDFSTPTFQLGFAASFVSYDYDRDAAGLKFI 858
            |   .|.||||.|::::|.|||||:|||:..|:.|.::.|.||:|..|.::....|.::  ::..
  Fly   795 L---TTNSPPYHIYYSFGIDNTPLRFHIELKKADGVYTVPLFQMGIGAHYMHVKGDDES--IRLA 854

  Fly   859 SDFPDFAHVMEWPTLYERYIF 879
            :..||:|..::||.:|::|||
  Fly   855 NSLPDYAVSIQWPAMYKKYIF 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	170/306 (56%)
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	170/306 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446891
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800