DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30047 and CG10073

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	421/866 - (48%)
Similarity:	585/866 - (67%)	Gaps:	14/866 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VNVLSQQKLRRH----RLPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLISHESSKPGQFVAER 79
            |...|.:|::..    |.|||.|..|||.|..||.|||.||::|:|..:.|  |.:..|.|:|||
  Fly    25 VRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLPLFYRIPTGLTI--EDASKGVFIAER 87

  Fly    80 AQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDVQHPSGAYMHWQMVN 144
            ||..|||..:||.|||||..||..||.:|...|..|:.....|.:::::|:|..||:|:||.|||
  Fly    88 AQSNLYKLAEIGTKVVGSDNNENKTVDYLMGLVNEIQENCLDDYFDIEVDLQEVSGSYIHWTMVN 152

  Fly   145 MYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEVLRQVAISDTPFEHP 209
            |||||.|:|:|:|.:::.|::||||||||||||:||.:||.|.|||.:|||||.:..:.....||
  Fly   153 MYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQAIRHP 217

  Fly   210 IVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGPNNPWLIKYYYQNAK 274
            :|||.||||||||:||||||||||||.|||.::||:.||:||.|::||:|||:|||::.|.:||.
  Fly   218 VVFLLNGAEENPLQASHGFITQHKWAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAP 282

  Fly   275 HPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFDNVQAVPIDSLQSSG 339
            |..||||||||||:|||||||||.||..||.|.|||||:..||:.|||.:|....:|..|:|::|
  Fly   283 HYLATTMAEEIFQTGILPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGSIQNTG 347

  Fly   340 DNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCCIAVASLVLVVCSLL 404
            ||.|.|||:.|::.|:.|.|.::.|||:|||.|||:|:.|||:.|::||..:|..:|||:..|:.
  Fly   348 DNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTESNGVILNYSVAGVALVLIFLSIW 412

  Fly   405 RMGRESDVSIGRVSIWFAIILVLHVLGMILSLGLPLLMAVLFDAGDRSMTYFSNNWLVIGLFIVP 469
            |....|.||||.|..||.:|.||.::..:|.||||:::|.:||....|:||||...|:|||:|.|
  Fly   413 RTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLPIVVAYVFDKYGLSITYFSTPVLLIGLYICP 477

  Fly   470 AIIGQILPLTLYYTLKPNDEISHPNHIHMSLHAHCVLLSLIAIILTAISLRTPYLCMMSLLFYGG 534
            :::|..||..:|..|:.::::....|:.:.||.|..:|:::.|.||...||:.|:...:|:||..
  Fly   478 SLLGLSLPSYIYLKLQRSEKVGFAQHLQLVLHGHAAVLAILDIGLTVYGLRSAYVPTWTLIFYVI 542

  Fly   535 ALLINLLSTLHDRGYYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFGHGTNPDLLIALICA 599
            .|.:|||:||||||:.|..::::.|:|||||..||.|.|::...||:||||..|||||:|:.:||
  Fly   543 PLAVNLLTTLHDRGFSWTGVLKIFQVVPFLYNSYLIYCFVVTLIPMMGRFGRATNPDLIISALCA 607

  Fly   600 VGTFFALGFVAPLINIFRWPKLALLGLGVVTFIFSMIAVS-EVGFPYRAKTSVMRIHFLHVRRIF 663
            :||..|||||.||:|:||.|.|.||.|..::.:....|.| ::|||||.||:|.|:.:|||||||
  Fly   608 LGTILALGFVIPLVNMFRRPSLILLTLLAISAVTIYTASSTQIGFPYRPKTNVQRLPYLHVRRIF 672

  Fly   664 YEYDGSVSLSDSGYYFDFQDRRLYYPLENTSVNLTGLASTSSECDKYLMCGVPCFNHRWCKTRAK 728
            |||||:|..:||||.|:|||||...||:.:.:|.|||.|.:::||..:|||.|.::|||.|.|.:
  Fly   673 YEYDGTVVKNDSGYLFNFQDRRGPAPLKLSKLNTTGLVSIAADCDTVMMCGFPLYDHRWVKNRLQ 737

  Fly   729 SHWLPREQEVAIPGATSLKLLSKAVLDSGKVARFEFEISGPPHMSLYIQPLDGVEVEDWSFIRNM 793
            ..|||||:|:..|....|:||||..|.:..: |..|:.:...|.|::||||:.|.:.:||...:.
  Fly   738 IMWLPREEEIITPYEPKLELLSKTELGNNTL-RMNFQSATTDHASVFIQPLEDVIISNWSLPTSY 801

  Fly   794 LDEPDTYSPPYQIFFAYGADNTPLKFHIDFAKSSGDFSTPTFQLGFAASFVSYDYDRDAAGLKFI 858
            :.:.||    ..::|:||.:||.|.|.|||.|...||:.|..|:|.|..|:.  ...||...:|.
  Fly   802 IGQQDT----SHMYFSYGKNNTALTFFIDFYKLDADFAVPLCQIGLAVHFIG--NKGDAISQEFA 860

  Fly   859 SDFPDFAHVMEWPTLYERYIF 879
            ...|.||..::||..|:||||
  Fly   861 KKIPSFAAAVDWPASYQRYIF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	176/306 (58%)
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	176/306 (58%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	107/239 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446896
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800