DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30047 and CG9416

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	896	Identity:	363/896 - (40%)
Similarity:	536/896 - (59%)	Gaps:	56/896 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSREKNGSAASNSDVALVNVLSQQKLRRHRLPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLI 65
            |||:.:|.....|               |.::.||:||.|:..|..|||.||.|.:||:|....:
  Fly     1 MKSKYENMKIIYN---------------RSKIGWYWAPLFVSCWFLLFYLVVIPSFHRMPQLKTL 50

  Fly    66 SHESSKPGQFVAERAQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDV 130
            ..|..:||||:.|||:..|.:..|||||||||.|||...|.||..|:.:|....|:|||:::.||
  Fly    51 EDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEIGDIIDDARTDLYDIEKDV 115

  Fly   131 QHPSGAYMHWQMVNMYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEV 195
            |..||.|:.|.|||:||.:.|||||:|.:::.|.:.||:||||||.|.|.|:||.|.|.|:||||
  Fly   116 QVASGNYLLWSMVNVYQSIQNVVVKLSPKNATSEAALLINSHFDSVPGSSGAGDAGMMCVIMLEV 180

  Fly   196 LRQVAISDTPFEHPIVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGP 260
            ||.:...:||..:.:||||||||||||:.||.|||||.||.|.:|:|||:.||||||::||||||
  Fly   181 LRVITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHPWAQNIRAVINLDSAGSGGREILFQSGP 245

  Fly   261 NNPWLIKYYYQNAKHPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFD 325
            ::|||:|||.:|..||||:|:.||:||:|.:||:||:|:|||||.:|||||||..|||||||.:|
  Fly   246 DHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYD 310

  Fly   326 NVQAVPIDSLQSSGDNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCC 390
            ....:|..:.|.:|:|.|:||:|.|:|.|::||..::|||.:|||.:|.|||||.|.|||::|..
  Fly   311 RFNLIPRRTYQLTGENILALVKALANAEELENPSKYAEGHMIFFDMMGWFFVYYPETTGIIINIT 375

  Fly   391 IAVASLVLVVCSLLRMGRESDVSIGRVSIW--FAIILVLHVLGMILSLGLPLLMAVLFDAGDRSM 453
            :.|...|.:|..:..|  .|...:.|..||  |.|:..|.:.|:.|.:||.:.:|:..||.:..|
  Fly   376 VCVLVCVTIVLYIWMM--SSSTGMFRRRIWAKFGILAALQLAGVALGIGLVISIALFLDAVNLPM 438

  Fly   454 TYFSNNWLVIGLFIVPAIIGQILPLTLYYTLKPNDEISHPNHIHMSLHAHCVLLSLIAIILTAIS 518
            ::||.||::.||:..|.|.|..:...:|::......:.....|.:.:|:||::|::|..|:.:.|
  Fly   439 SWFSQNWMLFGLYFCPMIFGMGIVPAIYFSRTKEHGLPLGYGIQLLMHSHCLILTIITAIMVSYS 503

  Fly   519 LRTPYLCMMSLLFYGGALLINLLSTLHDRGYYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGR 583
            :|:.::.|:.:.||..::||||::..|...:.|::...:.|::||:::.|..|.|.:||.||.||
  Fly   504 IRSAFVIMLCIGFYTLSVLINLVTKAHKTNFLWLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGR 568

  Fly   584 FGHGTNPDLLIALICAVGTFFALGFVAPLINIFRWPKLALLGLGVVTFIFSMIAVSEVGFPYRAK 648
             ...|||::|:....|:.......|:.||..:||..|..:...|:.|.:|.:.|.:.:.|||..|
  Fly   569 -ECNTNPEILMGFFTALMVLLFAPFLVPLFCLFRKSKTIISMFGICTIVFIIFAATPIAFPYAEK 632

  Fly   649 TSVMRIHFLHVRRIFYEYD--GSVSLSDSGYYFDFQDRRLY----YPLENTSVNLTGLASTSSEC 707
            |:..|...:|..|.|:..|  .:||..||||:....|||.:    ...|||  |.|  .|...:|
  Fly   633 TAPQRFFAVHTARTFHNGDPASTVSHKDSGYFVLPVDRRPHTVDDILFENT--NFT--KSERIDC 693

  Fly   708 DKYLMCGVPCFNHRWCKTRAKSHWLP-----REQEVAIPGATSLKLLSKAVLDSGKVARFEFEIS 767
            |..||||.|.::.||......|:::|     ||.   ||..|.|:..|    :|....||:.|||
  Fly   694 DSELMCGFPIYSSRWLNAVDNSYFVPGPEPNREY---IPTLTILEKSS----NSDTNIRFDLEIS 751

  Fly   768 GPPHMSLYIQPLDGVEVEDWSFIRNMLDEPDTYSPPYQIFFAYGADNTPLKFHIDFAKSSGDFST 832
            ||.|.|::|.||:..::.||||||:.||  ....|||.::::|..|..||:|.::|.....::|.
  Fly   752 GPDHTSIFILPLNDSKLVDWSFIRDPLD--GNVKPPYYVYWSYALDPKPLQFSLEFEHEDPNWSG 814

  Fly   833 PTFQLGFAA------SFVSYDYDRDAAGLKFISDFPDFAHVMEWPTLYERY 877
            .||::....      .:::.|:      .:|::.||.:|||..|...|..:
  Fly   815 GTFKIALMGHRIHDDMYITEDF------REFLATFPPWAHVSSWLGSYNSW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	175/306 (57%)
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	175/306 (57%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	60/201 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446920
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
	13	12.830