DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30047 and CG10051

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	878	Identity:	338/878 - (38%)
Similarity:	510/878 - (58%)	Gaps:	23/878 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SREKNGSAASNSDVALVNVLSQQKLRRHRLPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLISH 67
            :.||:|.                |.|..:.||:.||.:.....|||||.|.|.::..|..:..|.
  Fly     9 TEEKDGG----------------KSRDKKWPWFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSE 57

  Fly    68 ESSKPGQFVAERAQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDVQH 132
            |:..|.:|:.|||.|.|.:|..||.|:.||:.|||.|:.||..|::.|:...|.|||::::|.|:
  Fly    58 EALHPDKFIGERAMRQLAEYSAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQY 122

  Fly   133 PSGAYMHWQMVNMYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEVLR 197
            .|||:..|.|...|..::|||||||.:||::.:|||||||:||:..:|.:||||.|||||||.||
  Fly   123 SSGAFHLWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLR 187

  Fly   198 QVAISDTPFEHPIVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGPNN 262
            .::.|:....||:|||||||||..:..||||||||||:.|||||:||:..|:|||::|||:|||:
  Fly   188 VISRSERTLTHPVVFLFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNH 252

  Fly   263 PWLIKYYYQNAKHPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFDNV 327
            |||.|||..:..||:|.|:|||:||...:|||||||||||||.:||||||.:.|||||||.|||.
  Fly   253 PWLAKYYQASVPHPYAQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNF 317

  Fly   328 QAVPIDSLQSSGDNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCCIA 392
            :.|...:.||:|:|.|.|:.|.|:|||:.|...:.:||.|::|:||.|.:.|||:..|.:|..::
  Fly   318 KNVEYGTYQSTGENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVS 382

  Fly   393 VASLVLVVCSLLRMGRESDVSIGR-VSIWFAIILVLHVLGMILSLGLPLLMAVLFDAGDRSMTYF 456
            ||:.:.:..|:..|..::.....: |.:.||||.::....:.::.||.||:||.......:.:::
  Fly   383 VAAFICIGTSVYIMTLDNGADAPKAVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWY 447

  Fly   457 SNNWLVIGLFIVPAIIG-QILPLTLYYTLKPNDEISHPNHIHMSLHAHCVLLSLIAIILTAISLR 520
            ...|:..||:....... .|||.|.....|....:.....|...:||.|:||:|:.||:|.:.:|
  Fly   448 YGKWMAFGLYFCTLFFAFGILPATYIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMGIR 512

  Fly   521 TPYLCMMSLLFYGGALLINLLSTLHDRGYYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFG 585
            :.|..|:.:.||..::|:.::..|..:..|:|.:..:.|::||.::.|:.|..|:.|.||.||.|
  Fly   513 SSYFPMVGIFFYAISVLVQIVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDG 577

  Fly   586 HGTNPDLLIALICAVGTFFALGFVAPLINIFRWPKLALLGLGVVTFIFSMIAVSEVGFPYRAKTS 650
            ..::||::|::..........|||.|:::.||.||:.....||:|.||.::|.:..|||:..:.:
  Fly   578 PESSPDIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTSAGFPFVKQLA 642

  Fly   651 VMRIHFLHVRRIFYEYDGSVSLSDSGYYFDFQDRRLYYPLENTSVNLTGLASTSSECDKYLMCGV 715
            ..|.:.||.:|.|:..||: |..|||||....|.||:...:.|..|....:.|::.|.....||:
  Fly   643 PQRYYVLHTQRTFHNLDGT-SKQDSGYYIQPVDTRLHELDDTTFKNAEPESWTAATCAAEPYCGL 706

  Fly   716 PCFNHRWCKTRAKSHWLPREQEVAIPGATSLKLLSKAVLDSGKVARFEFEISGPPHMSLYIQPLD 780
            |.::.||.:.:..:.|:.....| ||...:|..|||..||..|| |:|:.:.....:.:||.|||
  Fly   707 PLYSGRWIEWKDSARWIYSSPPV-IPMNINLTQLSKQSLDGNKV-RYEYNLRASDRVMMYIDPLD 769

  Fly   781 GVEVEDWSFIRNMLDEPDTYSPPYQIFFAYGADNTPLKFHIDFAKSSGDFSTPTFQLGFAASFVS 845
            .|:|.||||....|.|..|  |||.|:..|.....||.|.::.....|:...|..:|..:..|..
  Fly   770 NVKVTDWSFDHTPLVEKHT--PPYLIYAIYSQTEEPLNFWVELEHEEGNTDGPYMKLVVSEHFQY 832

  Fly   846 YDYDRDAAGLKFISDFPDFAHVMEWPTLYERYI 878
            :.........:|::.|||:.:..:|.:..|.:|
  Fly   833 HPEYYTEEYKEFLATFPDWTYTTDWFSALESWI 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	168/306 (55%)
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	168/306 (55%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	68/242 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446930
Domainoid	1	1.000	318	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
	13	12.830