DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30047 and CG33012

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	869	Identity:	473/869 - (54%)
Similarity:	636/869 - (73%)	Gaps:	5/869 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SDVALVNVLSQQKLRRHRLPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLISHESSKPGQFVAE 78
            |:|.|:. |.|:.....:|.|||:|::||.||.||:||.|||::.||..|.|..|::.||.|||:
  Fly    46 SNVTLIE-LKQKSRFSKQLEWYYSPAYLLFWVGLFFAVCYPLFNHLPTGVKIEEEANLPGTFVAQ 109

  Fly    79 RAQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDVQHPSGAYMHWQMV 143
            ||:.:|.:.|.:|||:.|....||..|.||..|:..:|..||:|||::::|||..||:::||||:
  Fly   110 RAESILIRLDLMGPKIAGDYVTEVEMVEFLLGEISKVRDEMRNDLYDMEVDVQRSSGSFLHWQMI 174

  Fly   144 NMYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEVLRQVAISDTPFEH 208
            |||||:.|||||:||:||||:||||||||:||||||.|:||...|||.|||.||.:|.|:..|.|
  Fly   175 NMYQGIQNVVVKLSSKSSNSTSYLLVNSHYDSKPSSVGTGDAELMVVTMLETLRLMATSEETFLH 239

  Fly   209 PIVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGPNNPWLIKYYYQNA 273
            |||||||||||.|...||.||:.|:|:.|||||:||:.||:|||::|||.|||:|||:|.|.::|
  Fly   240 PIVFLFNGAEEQPFHGSHSFISNHRWSANCKALVNLDSAGAGGREILFQGGPNHPWLMKQYKKSA 304

  Fly   274 KHPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFDNVQAVPIDSLQSS 338
            ||||||||||||||:.::|||||||||||:|.:||||||...||:||||.||..:.:...:||::
  Fly   305 KHPFATTMAEEIFQADLIPSDTDFRIFRDFGPVPGLDMAGCYNGFVYHTKFDRYKVISRGALQNT 369

  Fly   339 GDNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCCIAVASLVLVVCSL 403
            |||.|||||:.::|.||.:.|.|||||:|||||||||||||||:||..||...::.:::::..||
  Fly   370 GDNVLSLVRSISNAEEMYDTEAHSEGHSVFFDYLGLFFVYYTESTGTALNISFSLGAILVICLSL 434

  Fly   404 LRMGRESDVSIGRVSIWFAIILVLHVLGMILSLGLPLLMAVLFDAGDRSMTYFSNNWLVIGLFIV 468
            .||.:.:|..:|..:..|.:..:|.:||.:|:||.||||:|.:|||||:||||||:||||||||.
  Fly   435 WRMAKVTDRRLGTYARAFGMQFLLAILGFLLALGFPLLMSVFYDAGDRTMTYFSNSWLVIGLFIC 499

  Fly   469 PAIIGQILPLTLYYTLKPNDEISHPNHIHMSLHAHCVLLSLIAIILTAISLRTPYLCMMSLLFYG 533
            |:|||.:||.|||.:|:|:::|.|..|:.:..||:||.::::.|:||.:.:||.||.||.:.||.
  Fly   500 PSIIGLVLPATLYLSLRPSEKIPHTYHLQIVGHAYCVFMAVLCILLTVVGIRTAYLFMMCVFFYL 564

  Fly   534 GALLINLLSTLHDRGYYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFGHGTNPDLLIALIC 598
            |||:|||.:.|||:||.|.:::.|.|::|:|||.|||:..|::..||..|.|...||||||:|.|
  Fly   565 GALIINLATRLHDKGYLWALVLCVCQILPYLYFTYLFHALLVITIPMTSRKGMDANPDLLISLEC 629

  Fly   599 AVGTFFALGFVAPLINIFRWPKLALLGLGVVTFIFSMIAVSEVGFPYRAKTSVMRIHFLHVRRIF 663
            |:|:..|:.|:|||:|:||.||..:.||.:|.|||.||:||:||||||..|:|||:|||.|.|.|
  Fly   630 ALGSILAMVFLAPLLNLFRRPKAMIGGLTLVMFIFCMISVSDVGFPYRPTTNVMRLHFLEVHRKF 694

  Fly   664 YEYDGSVSLSDSGYYFDFQDRRLYYPLENTSVNLTGLASTSSECDKYLMCGVPCFNHRWCKTRAK 728
            ||:|||:||.|||||||.||||...||.: .:||||:......|...:.||:||||||||.....
  Fly   695 YEFDGSISLEDSGYYFDLQDRRFENPLLD-KINLTGITRVDDYCKTEMYCGLPCFNHRWCSAVND 758

  Fly   729 SHWLPREQEVAIPGATSLKLLSKAVL--DSGKVARFEFEI-SGPPHMSLYIQPLDGVEVEDWSFI 790
            :.||||::.|.:||...|:.|:|.||  :|...|.:.|.: ||||.||.::||.|||.:..|||:
  Fly   759 ARWLPRDEPVDLPGTPILQFLNKTVLGTESAPRALYYFVVSSGPPRMSFFVQPRDGVRMLSWSFL 823

  Fly   791 RNMLDEPDTYSPPYQIFFAYGADNTPLKFHIDFAKSSGDFSTPTFQLGFAASFVSYDYDRDAAGL 855
            :.|||.|..|.|||.|||.||:|::|::|:.:..|..|:|..|..:||.:..::|:...|||...
  Fly   824 KGMLDNPSVYKPPYHIFFGYGSDDSPVEFYFEMTKDDGNFDGPVVELGISGHYMSHLSKRDATTQ 888

  Fly   856 KFISDFPDFAHVMEWPTLYERYIF 879
            |||.|.|||||.|||||.||||||
  Fly   889 KFIEDLPDFAHPMEWPTSYERYIF 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	191/306 (62%)
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	191/306 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446883
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800