DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30047 and ermp1

DIOPT Version :9

Sequence 1:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	XP_004910853.1	Gene:	ermp1 / 100145630	XenbaseID:	XB-GENE-984733	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	909	Identity:	267/909 - (29%)
Similarity:	442/909 - (48%)	Gaps:	77/909 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 REKNGSAASNSDVALVNVLSQQKLRRHRLPWYY-------APSFLLLWVALFYAVVYPLYHRLPD 61
            |.:|..||.:..    .:..::.:|..:.|...       .|..|||:|.....:|:....:|
Frog    12 RPRNNVAAESGS----GLRREESVREKKKPRQLDGGFGAAVPVLLLLYVLGVRGLVHISLRQL-- 70

  Fly    62 SVLISHESSKPG----QFVAERAQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSD 122
                    ..||    .|.|..|:..|.:...|..::|||..||:..|.:|..::::|...:.|
Frog    71 --------VTPGGHSTGFNASTAREYLQQITSIDSRIVGSPENEIIAVDYLLGKIKDIEEKVNS- 126

  Fly   123 LYELQLDVQHPSGAY---MHWQMVNMYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGD 184
            ::::.:|||.|:|.:   ......:.|..:||:.||:.. ...:...:|.|.||||..::||:.|
Frog   127 VHKITVDVQRPTGTFSIDFLGGFTSYYDNITNIAVKLEP-EFGAEHAVLANCHFDSVANTPGASD 190

  Fly   185 DGTMVVVMLEVLRQVAISDTPFEHPIVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGS 249
            |.....||||:|..:::|..|..|.|:|||||||||.|:.||||||||.||...:|.||||.||.
Frog   191 DAVSCAVMLEILGSLSVSSKPLRHAIIFLFNGAEENILQGSHGFITQHPWAKMVRAFINLEAAGV 255

  Fly   250 GGRDLLFQSGPNNPWLIKYYYQNAKHPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQI 314
            ||::|:||:||.||||::.|...|.||||:.:|:|:|||||:||||||||:||:|.:||:|:|.|
Frog   256 GGKELVFQTGPENPWLVQAYALAAVHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFI 320

  Fly   315 SNGYVYHTIFDNVQAVPIDSLQSSGDNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYY 379
            .|||:|||.:|....:..:|:|.:|||.|.::...|.:.::........|:.||||..|||.:.|
Frog   321 ENGYIYHTKYDTWNRILTESIQRAGDNILGVLHYLATSSQLAESSKFRHGNMVFFDVCGLFVLSY 385

  Fly   380 TENTGIVLNCCIAVASLVLVVCSLLRMGRESDVSIGRVSIW-FAIILVLHVLGMILSLGLPLLMA 443
            ....|.::|...|..:|..:...:::. ::...:..|..:: |.|.||..|..::    ..|::|
Frog   386 PARLGTIINYITAAVTLFYIGKKIIKY-KQGGTNYARDLVYGFLITLVSWVSALV----TVLIIA 445

  Fly   444 VLFDAGDRSMTYFSNNWLVIGLFIVPAIIGQILPLTL---YYTLKPNDEISHPNHIHMSLHAHCV 505
            ||.....:::.::::.::.:.|:...|:...||..:|   ::....:.:........:||...|:
Frog   446 VLVSLAGKALFWYTHFYVSVFLYGSAAVAKLILVHSLAKTFFFAGASSQYLGDVFFDISLIIWCI 510

  Fly   506 LLSLIAIILTAISLRTPYLCMMSLLFYGGALLINLL---STLHDRGYYWVVLVQVLQLV-PFLYF 566
            .|    ::||...|.:.|.....::|   .||..||   ..:|....|...::.:|.|. |:|:.
Frog   511 PL----VLLTQSGLCSAYFFAAWIIF---PLLTKLLLQPDIIHQGSPYKFTVIYLLGLFPPYLHT 568

  Fly   567 CYLFYTFLLVFFPMLGRFGHGTNPDLLIALICAVGTFFALGFVAPLINIFRWPKLALLGLGVVTF 631
            .|..:....:|.|:|||.|....||:::..:....|...:.:....|.:.:..|..::.|.|::.
Frog   569 MYHVWAVFEMFTPILGRSGTEIPPDVVLGFLIIACTIMLISYFISFIYLVKNTKNIIVPLAVLSV 633

  Fly   632 IFSMIAVSEVGFPYRAKT---SVMRIHFLHVRRIFYEYDGSVSLSDSGYYFDFQDRRLYYPLENT 693
            :..::..|.:.|||.:.|   ...||...|..|.|:...|.|...|||.:.:..|   |..:.:.
Frog   634 LTFLLVCSGMFFPYSSSTDSPKPKRIFLQHTTRTFHSLTGEVVKKDSGIWINGFD---YTGISHV 695

  Fly   694 SVNLTGLAST-SSECDKYLMCGVPCFNHRW---CKTRAKSHWLPREQEVAIPGATSLKLLSKAVL 754
            :.:...|..| .:.||...:||.|     |   .....:.:|........|...|..||:|:..:
Frog   696 TPHFPELNDTVRAPCDDAPLCGFP-----WYFPVHNLIRKNWYLPAPPAPIYEHTEFKLVSREEM 755

  Fly   755 DSGKVARFEFEISGPPHMSLYIQPLDGVEVEDWSF---IRNMLDEPDTYSPPYQIFFAYGADNTP 816
            ..| ..|..||..||.||::|::|.....:..||.   |.....|.|     |.||:::|.....
Frog   756 SWG-TTRLHFEAKGPSHMTVYVRPHADSVLSSWSLGDGIPIASGEKD-----YFIFYSHGLYAPA 814

  Fly   817 LKFHIDFAKSSGDFSTPTFQLGFAASFVSYDYDRDAAGLKFIS-DFPDFAHVMEWPTLYERYIF 879
            .||.|: .|:|.|.|.....:...:.:...| .|::..||.:. .|||::....|...|:.|::
Frog   815 WKFWIE-VKNSADESKGIVTVAVGSHYFFGD-SRNSPHLKTVELKFPDWSFPSSWVCTYDLYVY 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	134/313 (43%)
ermp1	XP_004910853.1	M28_Fxna_like	78..385	CDD:349872	132/308 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2323
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1875
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm47728
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090