DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30043 and TRE1

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_015149.1	Gene:	TRE1 / 855927	SGDID:	S000006097	Length:	783	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	92/486 - (18%)
Similarity:	176/486 - (36%)	Gaps:	117/486 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LYDLELDVQSPTGGYVFNDMVNMYQGI--HNVI--VKLSSKSSQSESYLLLNSHFD---SKPGSP 179
            :|..|:.::.|.....|::.|..::..  :||:  ||.:.....::...|.:..||   ||.|:
Yeast    41 VYVEEMGMEEPQAPEAFSEKVQRFRMCFENNVVIPVKKNVVDPLAQMISLASEKFDLFLSKIGN- 104

  Fly   180 GSGDDGTMVVVMMEVLRQMSISEIPFEHPIVFLFNGAEENPLQASHGFITQH----KWAEKCKAF 240
                    |:||..:...|.:|.|.   .::...:.......:.|:|..:.|    ::|.|....
Yeast   105 --------VMVMRRIFYIMMMSIIA---ALIIASDRLPNGKARGSNGSFSDHDLLLQYARKSIDL 158

  Fly   241 INLEVGGSGGRDLLF------QSGPNNPWLMKYYRQHAKHPFATTMAEEIFQSGV-LPSDSDFRI 298
            ..:|      |||.:      .||.:....:::|           :.|...::|: |..:.:|..
Yeast   159 SKIE------RDLEYISSMPHMSGTSGDAAIRHY-----------IKESFDKNGIRLAGEEEFMA 206

  Fly   299 FRDY-GNIA----------GLDIAQIENGYVYHTAFDTYENVPGRSIQNSGNNVLALVRAYSNAS 352
            :.:| ||::          |.||...|            ||....|.....||:..:   |:|.:
Yeast   207 YSNYPGNVSLRVYSKDDTEGFDIPLNE------------ENFNPMSHNGQLNNIPVI---YANKA 256

  Fly   353 ELYNTES-DDSHAVFFDFLGLFFVYYTETT--GIVVNCVIGVLSLVLVGCSVW--RMCHQSEEAS 412
            .|.:..| .|...:..||  :..|:|.:..  .::.....|..:::.:.....  :...|.:..:
Yeast   257 SLDDMASMQDQGLLNGDF--ILLVHYGDYVFQQMLTAQEYGAKAIIFISEPYQDNKDVIQMKSVA 319

  Fly   413 LPQISI-------WFLSILGLHVVGFLLCICLPLLMAVLFDA--GDRSLTYFTSNWLVFGLYVCP 468
            |||...       |..||  ...:......|||.:.::...|  ||:.|...:..
Yeast   320 LPQYGTGDALTPEWEGSI--RDPIDATEAKCLPKIPSIPISANQGDKILAILSDT---------- 372

  Fly   469 AIIGLVLPLTLYYTLLPNEKLSQAYQLQL-SLH-AHLVV-------QALLALILTAMGLRSQYLC 524
               |:.....|:...|.:.:|....|..: ..| .|.:|       ||..|:::.|....:.|..
Yeast   373 ---GVKFSNNLFSGSLNDCRLDLLVQTAIRERHPVHDIVGKIEGSEQAGRAIVIAAPRNSASYGT 434

  Fly   525 LISMIFYGGALLINLVSTLHDRGYY--WVPI 553
            :...  :|..:|::|:....:..|.  |.|:
Yeast   435 MYPS--FGTVVLLSLIQLYQEMVYKFDWKPL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	57/284 (20%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453	15/72 (21%)
TRE1	NP_015149.1	PA	221..374	CDD:333703	33/184 (18%)
		M28_PMSA_TfR_like	402..617	CDD:349871	14/64 (22%)
		TFR_dimer	642..769	CDD:398094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900