DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30043 and Folh1

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_476533.2	Gene:	Folh1 / 85309	RGDID:	70963	Length:	752	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	80/417 - (19%)
Similarity:	142/417 - (34%)	Gaps:	136/417 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DTELVESLSLRKGYVRRPRLSWYYAPSFLLLWLALFYAIVIPLYYRLPDRLTISEESHRPG---- 72
            |::..|:|        |.|..|:.|.:.:|.:...|....:..::..|...:.|..|: ||
  Rat     7 DSDSAEAL--------RRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSY-PGMKKA 62

  Fly    73 ---EFVAERAQQYLYTYDRIGPKVTGSYAN-------------------EVTTVEFLVNETEK-- 113
               |..||..:::||.:.|. |.:.|:..|                   |::..:.|::...|
  Rat    63 FLQELKAENIKKFLYNFTRT-PHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTH 126

  Fly   114 -----IRAEMRSDLYDLELDVQSPTGGYVFNDMVNMYQGIHNVIVKLSSKSSQSESYLLLNSHFD 173
                 |..|..::::...|...||.|          |:.|.:|:...|:.|.|
  Rat   127 PNYISIINEDGNEIFKTSLAELSPPG----------YENISDVVPPYSAFSPQ------------ 169

  Fly   174 SKPGSPGSGDDGTMVVV-------MMEVLRQMSIS----EIPFEHPIVFLFNGAEENPLQASHGF 227
               |:|    :|.:|.|       ..::.|.|.|:    .:...:..||..|..:...|..:.|.
  Rat   170 ---GTP----EGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGI 227

  Fly   228 ITQHKWAEKCKAFI----------NLEVGGSGGRDLLFQSGPNNPWLMKY------YRQH----- 271
            |.   :::....|:          ||..||....::|..:|..:|....|      ||..
  Rat   228 IL---YSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAV 289

  Fly   272 -----AKHPFATTMAEEIFQ--SGVLPSDSDFRIFRDYGNIAGLDIAQIENGYVYHTAFDTYENV 329
                 ..||.....|:::.:  .|..|.||.::        .||.:              .|...
  Rat   290 GLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWK--------GGLKV--------------PYNVG 332

  Fly   330 PGRSIQNSGNNVLALVRAYSNASELYN 356
            ||.:...|...|...:.:|:..:.:||
  Rat   333 PGFAGNFSKQKVKLHIHSYNKVTRIYN 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	68/358 (19%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453
Folh1	NP_476533.2	Zinc_peptidase_like	60..>117	CDD:417508	10/57 (18%)
		PA_GCPII_like	122..348	CDD:239036	52/279 (19%)
		NAALADase	276..589		19/106 (18%)
		M28_PSMA_like	<356..597	CDD:349942	2/4 (50%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Q0	519..520
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q04609	536..538
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Q0	554..555
		TFR_dimer	629..749	CDD:398094
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Q0	701..702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900