DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30043 and PFF1

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_009630.3	Gene:	PFF1 / 852366	SGDID:	S000000278	Length:	976	Species:	Saccharomyces cerevisiae

Alignment Length:	724	Identity:	164/724 - (22%)
Similarity:	283/724 - (39%)	Gaps:	194/724 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YAPSFLLLWLALFYAIVIPLYYRLPDR--LTISEESHRP----------GEFVAERAQQYLYT-- 85
            |..:.|.|.|.:.|:|:..||....:|  |.:.:|...|          |:.....|..:.||
Yeast    13 YRKTNLSLLLLITYSIITLLYIFDHERYKLNLPKEDEHPEFNDLLETAWGDLQIITASFHPYTSK 77

  Fly    86 -----YDRIGPKVTGSYANEVTTVEFLVNETEKIRAEMRSDLYDLELDVQSPTGGYVFNDMVNM- 144
                 :|.:..:|.     |:|......:.::...:| ||.|:    ..|.|     ||:....
Yeast    78 ENDKVHDYLLKRVL-----EITGNSSFASVSDDKESE-RSILF----QQQDP-----FNESSRFS 127

  Fly   145 ---YQGIHNVIVKLSSKSSQSESYLLLNSHFDSKPGSPGSGDDGTMVVVMMEVLRQMSISEIPFE 206
               |....|::|||..|:.:.|. |||::||||.|...|:.|||..||.::..|: ..|...| .
Yeast   128 RVTYFESSNILVKLEGKNPEEEG-LLLSAHFDSVPTGYGATDDGMGVVSLLANLK-YHIKHRP-N 189

  Fly   207 HPIVFLFNGAEENPLQASHGFITQHKWAEKCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQH 271
            ..::|.||..||..|..:..:. .|.|:...|..||||..|:||:.:||::...:  ..:.|:|.
Yeast   190 RTLIFNFNNNEEFGLLGASTYF-DHSWSNLTKYVINLEGTGAGGKAVLFRTSDTS--TARIYQQS 251

  Fly   272 AK-HPFATTMAEEIFQSGVLPSDSDFRIFRDYGNIAGLDIAQIENGYVYHTAFDTYENVPGRSIQ 335
            .| :||..::.::.|.|..:.|::|::|:.:.| :.|.|:|..:...:|||..|:.:.....|:.
Yeast   252 VKENPFGNSIYQQGFYSRYVRSETDYKIYEENG-MRGWDVAFYKPRNLYHTIKDSIQYTSKASLW 315

  Fly   336 NSGNNVLALVRAYSNASELYNTESDDSHAVFFDFLGLFFVYYTETTGIVVNCVIGVLSLVLVGCS 400
            :..:..|.| .||..::.|  ..:|.:.|.:|||:||.|...:..|....||:..::|.|:.
Yeast   316 HMLHTSLQL-SAYVASNSL--DTADQTPACYFDFIGLKFFVISAKTLFYWNCIFLLVSPVVA--- 374

  Fly   401 VWRMCHQSEEASLPQISIWFLSILGLHVVGFLLCICLPLLMAVLFDAGDRSLTYFTSNWLVFGLY 465
                                   :||:::                 :.|| :|:.:.:|
Yeast   375 -----------------------IGLYLI-----------------SRDR-MTWKSYSW------ 392

  Fly   466 VCPAIIGLVLPLTLYYTLLPNEKLSQAYQLQLSLHAHLVVQALLALILTAMGLRSQYLCLISMIF 530
                         |.:|..|           |||.|.::||.|.:..:    :||..|..
Yeast   393 -------------LSWTRFP-----------LSLAAGIIVQKLFSNDI----IRSNPLTF----- 424

  Fly   531 YGGALLINLVSTLHDRGYYWVPIVMFLQVLPFSYF---CYLFY-------------MFLVIFIPV 579
                          .|.|:|.....|.||:..||.   |..|:             :|::::..:
Yeast   425 --------------SRNYFWPISAFFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWTIL 475

  Fly   580 LGRNGYSTNPDLIVGLLCGVCVFFALGFAAQLINMFRWPKLILLGLGVMTFIFCMIAVSDVGFPY 644
            |..:....:.|.....|..:.:||.|...|.::      :|:.|.||:
Yeast   476 LFTSKLLYSSDYRYTGLYPLSIFFLLSTIAAIL------RLLALALGM----------------- 517

  Fly   645 RAKTNVMR------ANCLHTRRIFYEHDGSVS-RSDSGYYFNYQDRRAFAPLEDSALDLTGLEPV 702
            |.:..:.|      :|.....:|..|.||..: ........:.||.:  |.::|..:..|...|.
Yeast   518 RTRKRLGRECRDHHSNYSSHSQIDMERDGQENLEQPQDQLTSSQDDQ--ASIQDDNVSTTSAGPS 580

  Fly   703 ANRCDDYVM 711
            .|..:|:.|
Yeast   581 HNVDEDHGM 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	91/327 (28%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453	32/156 (21%)
PFF1	NP_009630.3	M28_Fxna_like	50..354	CDD:349872	91/328 (28%)
PFF1	NP_009630.3	DUF2189	366..>443	CDD:413262	27/173 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343310
Domainoid	1	1.000	99	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm46574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840