DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30043 and Tfrc

DIOPT Version :9

Sequence 1:NP_725143.1 Gene:CG30043 / 246412 FlyBaseID:FBgn0050043 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_073203.1 Gene:Tfrc / 64678 RGDID:70488 Length:761 Species:Rattus norvegicus


Alignment Length:195 Identity:43/195 - (22%)
Similarity:71/195 - (36%) Gaps:46/195 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 QSESYLLLNSHFDS-KPG----SPGSGDDGTMVVVMMEVLRQMSISEIPF--EHPIVFLFNGAEE 218
            :.:.|:::.:..|: .||    |.|:|    :::.:.:|...| ||:..|  ...|:|....|  
  Rat   399 EPDRYIVVGAQRDAWGPGVAKSSVGTG----LLLKLAQVFSDM-ISKDGFRPSRSIIFASWTA-- 456

  Fly   219 NPLQASHGFITQHKWAE--------KCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQHAKHP 275
                ..:|.:...:|.|        |...:|||:....|..:....:.|....||....|..|||
  Rat   457 ----GDYGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTLMGKIMQDVKHP 517

  Fly   276 -----------FATTMAEEIFQSGVLPSDSDFRIFRDYGNIAGLDIAQIEN-GYVY-HTAFDTYE 327
                       :.:.:.|....:...|       |..|..|..:.....|: .|.| .|..||||
  Rat   518 IDGKYLYRDSNWISKIEELSLDNAAFP-------FLAYSGIPAVSFCFCEDEDYPYLGTKLDTYE 575

  Fly   328  327
              Rat   576  575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30043NP_725143.1 M28_Fxna_like 71..377 CDD:193497 43/195 (22%)
PMT_2 493..>634 CDD:304453
TfrcNP_073203.1 Mediates interaction with SH3BP4. /evidence=ECO:0000250|UniProtKB:P02786 1..67
Endocytosis signal. /evidence=ECO:0000250|UniProtKB:P02786 20..23
Stop-transfer sequence. /evidence=ECO:0000250|UniProtKB:P02786 58..61
PA_TfR 201..378 CDD:239043
M28_TfR 386..611 CDD:349946 43/195 (22%)
Ligand-binding. /evidence=ECO:0000250 570..761 4/6 (67%)
TFR_dimer 638..751 CDD:398094
Cell attachment site, required for binding to transferrin. /evidence=ECO:0000250|UniProtKB:P02786 647..649
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2234
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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