DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30043 and Ermp1

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_006231303.1	Gene:	Ermp1 / 373544	RGDID:	727831	Length:	899	Species:	Rattus norvegicus

Alignment Length:	894	Identity:	276/894 - (30%)
Similarity:	439/894 - (49%)	Gaps:	120/894 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LWLALFYAIVIPLYYRLPDRLTISEESHRPGEFVAERAQQYLYTYDRIGPKVTGSYANEVTTVEF 106
            |.|||:...:..|......||.:|..|...|||.|.:|:.||.....|||:.|||..||:.||::
  Rat    69 LALALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARVYLEHITAIGPRTTGSAENEILTVQY 133

  Fly   107 LVNETEKIRAEMRSDLYDLELDVQSPTGGY---VFNDMVNMYQGIHNVIVKLSSKSSQSESYLLL 168
            |:.:...|. |..:.|:.:.:|||.|||.:   ......:.|..|.||:|||..:.. ::..:|.
  Rat   134 LLEQITLIE-EQSNSLHRISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPQDG-AKYAVLA 196

  Fly   169 NSHFDSKPGSPGSGDDGTMVVVMMEVLRQMSISEIPFEHPIVFLFNGAEENPLQASHGFITQHKW 233
            |.||||...|||:.||.....||:||||.|:.|..|.:|.:||||||||||.|||||||||||.|
  Rat   197 NCHFDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPW 261

  Fly   234 AEKCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQHAKHPFATTMAEEIFQSGVLPSDSDFRI 298
            |...:||||||..|.||::|:||:||.||||::.|...||||||:.:|:|:||||::|||:||||
  Rat   262 ASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRI 326

  Fly   299 FRDYGNIAGLDIAQIENGYVYHTAFDTYENVPGRSIQNSGNNVLALVRAYSNASELYNTESDDSH 363
            :||:|||.|:|:|.|||||:|||.:||.:.:...|||.:|:|:||::: |...|::..:.|:..|
  Rat   327 YRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLK-YLATSDMLASSSEYRH 390

  Fly   364 A--VFFDFLGLFFVYYTETTGIVVNCVIGVLSLVLVGCSVWRMCHQSEEASLPQISIWFLSILGL 426
            .  ||||.|||..:.|....|.::|.::.:..::.:|..:.|..|::......     ||..||:
  Rat   391 GSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKLLRPKHRNSNYVRD-----FLCGLGI 450

  Fly   427 HVVGFLLCICLPLLMAVLFDAGDRSLTYFTSNWLVFGLYVCPAIIGLVLPLTL----YYTLLPNE 487
            ..:.:...:...|::||......:||:::...::...||....:..::|..||    ||.
  Rat   451 TFISWFTSLVTVLIIAVFVSLIGQSLSWYNYFYIAVCLYGTATVAKIILIHTLAKRFYYV----- 510

  Fly   488 KLSQAYQLQLSLHAHLVVQALLALILTAMGLRSQYLCLISMIFYGGALLINLV----STLHDRGY 548
            ..|..|..:|.....|.|.....:.|||.|..|.::..:.:.|   .||..|.    ...|....
  Rat   511 NASDLYLGELFFDTSLFVHCGFLVALTAQGFCSAFMSAVWVAF---PLLTKLCVYKDFKKHGAKG 572

  Fly   549 YWVPIVMFLQVLPFSYFCYLFYMFLVIFIPVLGRNGYSTNPDLIVGLLCGVCVFFALGFAAQLIN 613
            .::.:.:....:|:.|..||.:....:|.|:|||:|....||:::..:..|||.....:....|.
  Rat   573 RFIALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIY 637

  Fly   614 MFRWPKLILLGLGVMTFIFCMIAVSDVGFPYRAKTN---VMRANCLHTRRIFYEHDGSVSRSDSG 675
            :....|..:|.|.::..:..::..|...|||.:..:   ..|....|..|.|:..:|||.:.|||
  Rat   638 LVNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSG 702

  Fly   676 YYFNYQDRRAFAPLEDSALDLTGL-----------EPVANRCDDYV-MCGIPCFYYSWCKW---- 724
            .:.|             ..|.||:           :.:...|::.. :||.|        |
  Rat   703 IWIN-------------GFDYTGMSHVTPHIPEINDTIRAHCEENAPLCGFP--------WYLPV 746

  Fly   725 -----RQWDGWLPRES---------EVILPGELTLDFLGYTVLESGTVARYEFELAGPPHMNLFI 775
                 :.|  :||...         .::...::..|.:..|           ||..||.||:.::
  Rat   747 HFLIRKNW--YLPAPEISPRNPAHFRLVSKEKMPWDSIKLT-----------FEATGPSHMSFYV 798

  Fly   776 QPVGSAKVDDWSFVRKMLDEPEEFQP------PYQIFHSYGTDNTSLKFFIDM-----EKPDGIF 829
            :....:.:..||....:        |      .|.:|:|:|...::.:|:|::     |:|:|:.
  Rat   799 RTHKGSTLSQWSLGNGI--------PVTSRGGDYFVFYSHGLQASAWQFWIEVQQVSEEQPEGMV 855

  Fly   830 DTPTLELAAVGHWVSFEYERDAEAKDFVAAFPDFVHVMEWPSIFKRYIF 878
               |:.:||  |::|.|.:|.::.......|||:.....|.|.:..::|
  Rat   856 ---TVAIAA--HYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	152/310 (49%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453	33/144 (23%)
Ermp1	XP_006231303.1	M28_Fxna_like	99..406	CDD:193497	152/309 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339538
Domainoid	1	1.000	242	1.000	Domainoid score	I2158
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1759
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm44686
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770