DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30043 and CG9416

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	347/855 - (40%)
Similarity:	522/855 - (61%)	Gaps:	29/855 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RPRLSWYYAPSFLLLWLALFYAIVIPLYYRLPDRLTISEESHRPGEFVAERAQQYLYTYDRIGPK 92
            |.::.||:||.|:..|..|||.:|||.::|:|...|:.:|..:||:|:.|||:..|....:||||
  Fly    14 RSKIGWYWAPLFVSCWFLLFYLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPK 78

  Fly    93 VTGSYANEVTTVEFLVNETEKIRAEMRSDLYDLELDVQSPTGGYVFNDMVNMYQGIHNVIVKLSS 157
            |.||.|||...|:||::|...|..:.|:||||:|.|||..:|.|:...|||:||.|.||:||||.
  Fly    79 VVGSAANEQVAVQFLLSEIGDIIDDARTDLYDIEKDVQVASGNYLLWSMVNVYQSIQNVVVKLSP 143

  Fly   158 KSSQSESYLLLNSHFDSKPGSPGSGDDGTMVVVMMEVLRQMSISEIPFEHPIVFLFNGAEENPLQ 222
            |::.||:.||:||||||.|||.|:||.|.|.|:|:||||.::..|.|..:.:|||||||||||||
  Fly   144 KNATSEAALLINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQ 208

  Fly   223 ASHGFITQHKWAEKCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQHAKHPFATTMAEEIFQS 287
            .||.|||||.||:..:|.|||:..|||||::||||||::|||||||.::..||||:|:.||:||:
  Fly   209 GSHAFITQHPWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQN 273

  Fly   288 GVLPSDSDFRIFRDYGNIAGLDIAQIENGYVYHTAFDTYENVPGRSIQNSGNNVLALVRAYSNAS 352
            |.:||::|:|:|||||:|.|||:||..|||||||.:|.:..:|.|:.|.:|.|:||||:|.:||.
  Fly   274 GFVPSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANAE 338

  Fly   353 ELYN-TESDDSHAVFFDFLGLFFVYYTETTGIVVNCVIGVLSLVLVGCSVWRMCHQSEEASLPQI 416
            ||.| ::..:.|.:|||.:|.|||||.|||||::|..:.||..|.:...:|.|   |....:.:.
  Fly   339 ELENPSKYAEGHMIFFDMMGWFFVYYPETTGIIINITVCVLVCVTIVLYIWMM---SSSTGMFRR 400

  Fly   417 SIW--FLSILGLHVVGFLLCICLPLLMAVLFDAGDRSLTYFTSNWLVFGLYVCPAIIGLVLPLTL 479
            .||  |..:..|.:.|..|.|.|.:.:|:..||.:..:::|:.||::||||.||.|.|:.:...:
  Fly   401 RIWAKFGILAALQLAGVALGIGLVISIALFLDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIVPAI 465

  Fly   480 YYTLLPNEKLSQAYQLQLSLHAHLVVQALLALILTAMGLRSQYLCLISMIFYGGALLINLVSTLH 544
            |::......|...|.:||.:|:|.::..::..|:.:..:||.::.::.:.||..::|||||:..|
  Fly   466 YFSRTKEHGLPLGYGIQLLMHSHCLILTIITAIMVSYSIRSAFVIMLCIGFYTLSVLINLVTKAH 530

  Fly   545 DRGYYWVPIVMFLQVLPFSYFCYLFYMFLVIFIPVLGRNGYSTNPDLIVGLLCGVCVFFALGFAA 609
            ...:.|:......|||||.::.|..|.|.|:|:|:.||. .:|||::::|....:.|.....|..
  Fly   531 KTNFLWLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGRE-CNTNPEILMGFFTALMVLLFAPFLV 594

  Fly   610 QLINMFRWPKLILLGLGVMTFIFCMIAVSDVGFPYRAKTNVMRANCLHTRRIFYEHD--GSVSRS 672
            .|..:||..|.|:...|:.|.:|.:.|.:.:.|||..||...|...:||.|.|:..|  .:||..
  Fly   595 PLFCLFRKSKTIISMFGICTIVFIIFAATPIAFPYAEKTAPQRFFAVHTARTFHNGDPASTVSHK 659

  Fly   673 DSGYYFNYQDRRAFAPLEDSALDLTGLEPVANR--CDDYVMCGIPCFYYSWCKWRQWDGWLPRES 735
            ||||:....|||... ::|...:.|.... :.|  ||..:|||.|.:...|..        ..::
  Fly   660 DSGYFVLPVDRRPHT-VDDILFENTNFTK-SERIDCDSELMCGFPIYSSRWLN--------AVDN 714

  Fly   736 EVILPG-ELTLDFL-GYTVLE----SGTVARYEFELAGPPHMNLFIQPVGSAKVDDWSFVRKMLD 794
            ...:|| |...::: ..|:||    |.|..|::.|::||.|.::||.|:..:|:.||||:|..||
  Fly   715 SYFVPGPEPNREYIPTLTILEKSSNSDTNIRFDLEISGPDHTSIFILPLNDSKLVDWSFIRDPLD 779

  Fly   795 EPEEFQPPYQIFHSYGTDNTSLKFFIDMEKPDGIFDTPTLELAAVGHWVSFEYERDAEAKDFVAA 859
              ...:|||.::.||..|...|:|.::.|..|..:...|.::|.:||.:..:.....:.::|:|.
  Fly   780 --GNVKPPYYVYWSYALDPKPLQFSLEFEHEDPNWSGGTFKIALMGHRIHDDMYITEDFREFLAT 842

  Fly   860 FPDFVHVMEW 869
            ||.:.||..|
  Fly   843 FPPWAHVSSW 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	172/306 (56%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453	44/140 (31%)
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	172/306 (56%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	62/201 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446921
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800