DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30043 and FOLH1

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_016872921.1	Gene:	FOLH1 / 2346	HGNCID:	3788	Length:	805	Species:	Homo sapiens

Alignment Length:	357	Identity:	71/357 - (19%)
Similarity:	125/357 - (35%)	Gaps:	110/357 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 IGPKVTGSYANEVTTVEFLVNETEKIRAEMRSDLYDLELDVQSPTGGYVFNDMVNMYQGIHNVIV 153
            :||..||:::            |:|::..:.|.                 |::..:|    |||.
Human   384 VGPGFTGNFS------------TQKVKMHIHST-----------------NEVTRIY----NVIG 415

  Fly   154 KLSSKSSQSESYLLLNSHFDSKPGSPGSGDDGTMVVVMMEVLRQMSISEIPFEHP---IVFLFNG 215
            .|.. :.:.:.|::|..|.||  ...|..|..:...|:.|::|.....:.....|   |:|....
Human   416 TLRG-AVEPDRYVILGGHRDS--WVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWD 477

  Fly   216 AEENPLQASHGFITQHKWAEKCK--------AFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQHA 272
            |||      .|.:...:|||:..        |:||.:....|...|.....|....|:....:..
Human   478 AEE------FGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKEL 536

  Fly   273 KHPFATTMAEEIFQS----------------GVLPSDSDFRIFRDYGNIAGLDIAQIEN------ 315
            |.|......:.:::|                ..|.|.:||.:|.....||.......:|
Human   537 KSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKF 601

  Fly   316 -GY-VYHTAFDTYE-----------------NVPGRSIQNSGNNVL---------ALVRAYSNAS 352
             || :||:.::|||                 .|.|..:....|:::         .::|.|  |.
Human   602 SGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKY--AD 664

  Fly   353 ELY-----NTESDDSHAVFFDFLGLFFVYYTE 379
            ::|     :.:...:::|.||.|......:||
Human   665 KIYSISMKHPQEMKTYSVSFDSLFSAVKNFTE 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	69/353 (20%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453
FOLH1	XP_016872921.1	Zinc_peptidase_like	113..>169	CDD:301362
		PA_GCPII_like	175..401	CDD:239036	6/28 (21%)
		M28_PSMA_like	403..650	CDD:193568	55/276 (20%)
		TFR_dimer	687..802	CDD:282153	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900