DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30043 and Ermp1

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	NP_001349060.1	Gene:	Ermp1 / 226090	MGIID:	106250	Length:	899	Species:	Mus musculus

Alignment Length:	894	Identity:	277/894 - (30%)
Similarity:	439/894 - (49%)	Gaps:	120/894 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LWLALFYAIVIPLYYRLPDRLTISEESHRPGEFVAERAQQYLYTYDRIGPKVTGSYANEVTTVEF 106
            |.|||:...:..|......||.:|..|...|||.|.:|:.||.....|||:.|||..||:.||::
Mouse    69 LALALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARDYLEHITAIGPRTTGSTENEILTVQY 133

  Fly   107 LVNETEKIRAEMRSDLYDLELDVQSPTGGY---VFNDMVNMYQGIHNVIVKLSSKSSQSESYLLL 168
            |:.:.:.|.|:..| |:.:.:|:|.|||.:   ......:.|..|.||:|||..:.. :||.:|.
Mouse   134 LLEQIKLIEAQSNS-LHSISVDIQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDG-AESAILA 196

  Fly   169 NSHFDSKPGSPGSGDDGTMVVVMMEVLRQMSISEIPFEHPIVFLFNGAEENPLQASHGFITQHKW 233
            |.||||...|||:.||.....||:||||.||.|..|.:|.:||||||||||.|||||||||||.|
Mouse   197 NCHFDSVANSPGASDDAVSCAVMLEVLRVMSASPEPMQHAVVFLFNGAEENVLQASHGFITQHPW 261

  Fly   234 AEKCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQHAKHPFATTMAEEIFQSGVLPSDSDFRI 298
            |...:||||||..|.||::|:||:||.||||::.|...||||||:.:|:|:||||::|||:||||
Mouse   262 ASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRI 326

  Fly   299 FRDYGNIAGLDIAQIENGYVYHTAFDTYENVPGRSIQNSGNNVLALVRAYSNASELYNTESDDSH 363
            :||:|||.|:|:|.|||||:|||.:||.:.:...|||.:|:|:||:::..:.:..|.:: |:..|
Mouse   327 YRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKHLATSDTLASS-SEYRH 390

  Fly   364 A--VFFDFLGLFFVYYTETTGIVVNCVIGVLSLVLVGCSVWRMCHQSEEASLPQISIWFLSILGL 426
            .  ||||.|||..:.|....|.::|.::.:..::.:|..:.|..|::......     ||..||:
Mouse   391 GSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGKKLLRPKHRNANYMRD-----FLCGLGI 450

  Fly   427 HVVGFLLCICLPLLMAVLFDAGDRSLTYFTSNWLVFGLYVCPAIIGLVLPLTL----YYTLLPNE 487
            ..:.:...:...|::||......:||:::...::...||....:..::...||    ||.
Mouse   451 TFISWFTSLVTVLIIAVFISLIGQSLSWYNYFYIAVCLYGTATVAKIIFIHTLAKRFYYM----- 510

  Fly   488 KLSQAYQLQLSLHAHLVVQALLALILTAMGLRSQYLCLISMIFYGGALLINLV----STLHDRGY 548
            ..|..|..:|.....|.|.....:.||..|..|.::..:.::|   .||..|.    ...|....
Mouse   511 NASDLYLGELFFDTSLFVHCAFLVALTYQGFCSAFMSAVWVVF---PLLTKLCVYKDFKKHGAQG 572

  Fly   549 YWVPIVMFLQVLPFSYFCYLFYMFLVIFIPVLGRNGYSTNPDLIVGLLCGVCVFFALGFAAQLIN 613
            .:|.:.:....:|:.|..||.:....:|.|:|||:|....||:::..:..|||.....:....|.
Mouse   573 RFVALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIY 637

  Fly   614 MFRWPKLILLGLGVMTFIFCMIAVSDVGFPYRA---KTNVMRANCLHTRRIFYEHDGSVSRSDSG 675
            :....|..:|.|.::..:..::..|...|||.:   .....|....|..|.|:..:|||.:.|||
Mouse   638 LVNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPESPKPKRVFLQHVSRTFHNLEGSVVKRDSG 702

  Fly   676 YYFNYQDRRAFAPLEDSALDLTGL-----------EPVANRC-DDYVMCGIPCFYYSWCKW---- 724
            .:.|             ..|.||:           :.:...| :|..:||.|        |
Mouse   703 IWIN-------------GFDYTGMSHVTPHIPEINDTIRAHCEEDAPLCGFP--------WYLPV 746

  Fly   725 -----RQWDGWLPRES---------EVILPGELTLDFLGYTVLESGTVARYEFELAGPPHMNLFI 775
                 :.|  :||...         .::...::..|.:..|           ||..||.||:.::
Mouse   747 HFLIRKNW--YLPAPEVSPRNPAHFRLVSKEKMPWDSIKLT-----------FEATGPSHMSFYV 798

  Fly   776 QPVGSAKVDDWSFVRKMLDEPEEFQP------PYQIFHSYGTDNTSLKFFIDM-----EKPDGIF 829
            :....:.:..||....:        |      .|.:|:|:|...::.:|:|::     |:.:|:.
Mouse   799 RTHKGSTLSQWSLGNGI--------PVTSRGGDYFVFYSHGLQASAWRFWIEVQQVSEEQAEGMV 855

  Fly   830 DTPTLELAAVGHWVSFEYERDAEAKDFVAAFPDFVHVMEWPSIFKRYIF 878
               |:.:||  |::|.|.:|.::.......|||:.....|.|.:..::|
Mouse   856 ---TVAIAA--HYLSGENKRSSQLDALKKKFPDWSFPSAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	154/310 (50%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453	33/144 (23%)
Ermp1	NP_001349060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
Ermp1	NP_001349060.1	M28_Fxna_like	99..406	CDD:193497	154/309 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835901
Domainoid	1	1.000	247	1.000	Domainoid score	I2148
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm42620
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760