DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30043 and NAALAD2

DIOPT Version :9

Sequence 1:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster
Sequence 2:	XP_016872532.1	Gene:	NAALAD2 / 10003	HGNCID:	14526	Length:	775	Species:	Homo sapiens

Alignment Length:	347	Identity:	81/347 - (23%)
Similarity:	120/347 - (34%)	Gaps:	108/347 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 IGPKVTGSYANEVTTVEFLVNETEKIRAEMRSDLYDLELDVQSPTGGYVFNDMVNMYQGIHNVIV 153
            |||..|||            :...|:|.                   :|:|  :|....|:||:.
Human   354 IGPGFTGS------------DSFRKVRM-------------------HVYN--INKITRIYNVVG 385

  Fly   154 KLSSKSSQSESYLLLNSHFDSKPGSPGSGDDGTMVVVMMEVLRQ----MSISEIPFEHPIVFLFN 214
            .:.. |.:.:.|::|..|.||  ...|:.|..:.|.|:.|:.|.    ||....| ...|:|...
Human   386 TIRG-SVEPDRYVILGGHRDS--WVFGAIDPTSGVAVLQEIARSFGKLMSKGWRP-RRTIIFASW 446

  Fly   215 GAEENPLQASHGFITQHKWA--------EKCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQH 271
            .|||      .|.:...:||        |:..|:||.:....|...|.....|....|:....:.
Human   447 DAEE------FGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKE 505

  Fly   272 AKHPFATTMAEEIFQSGV----------------LPSDSDFRIFRDYGNIAGLDIAQIEN----- 315
            ...|.....::.:::|.:                |.|.|||..:.....||.......:|
Human   506 IPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDK 570

  Fly   316 --GY-VYHTAFDTYENV-----PGRSIQNS-----GNNVLALV-------------RAYSN-ASE 353
              .| ||||.::|:|.|     |....|.|     |..|..||             .|..| |:.
Human   571 YSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAAS 635

  Fly   354 LYN-TESDD----SHAVFFDFL 370
            :|| ::..|    .|.|.||.|
Human   636 IYNLSKKHDQQLTDHGVSFDSL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	81/347 (23%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453
NAALAD2	XP_016872532.1	Zinc_peptidase_like	93..>139	CDD:301362
		PA_GCPII_like	145..371	CDD:239036	8/47 (17%)
		M28_PSMA_like	373..620	CDD:193568	61/258 (24%)
		TFR_dimer	657..772	CDD:282153	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900