DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30025 and TMPRSS2

DIOPT Version :10

Sequence 1:NP_725036.1 Gene:CG30025 / 246398 FlyBaseID:FBgn0050025 Length:253 Species:Drosophila melanogaster
Sequence 2:NP_001128571.1 Gene:TMPRSS2 / 7113 HGNCID:11876 Length:529 Species:Homo sapiens


Alignment Length:267 Identity:92/267 - (34%)
Similarity:130/267 - (48%) Gaps:36/267 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KFVILLSAVACALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSSNVIV 67
            |.|:.|..:||.:      .|......|||||.:....::|||:||.....|.|||||.:...||
Human   271 KAVVSLRCIACGV------NLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIV 329

  Fly    68 TAAHCLQ---------SVSASVLQIRAGSSYWSSGGVTFSVSSFKNHEGYNANTMVNDIAIIKIN 123
            |||||::         :..|.:|  |....::.:|   :.|....:|..|::.|..||||::|:.
Human   330 TAAHCVEKPLNNPWHWTAFAGIL--RQSFMFYGAG---YQVEKVISHPNYDSKTKNNDIALMKLQ 389

  Fly   124 GALTFSSTIKAIGLASSNPANGAAAS----VSGWG-TLSYGSSSIPSQLQYVNVNIVSQSQCASS 183
            ..|||:..:|.:.|  .||.......    :|||| |...|.:|  ..|....|.::...:| :|
Human   390 KPLTFNDLVKPVCL--PNPGMMLQPEQLCWISGWGATEEKGKTS--EVLNAAKVLLIETQRC-NS 449

  Fly   184 TYGYGSQIRSTMICAA--ASGKDACQGDSGGPLVSG----GVLVGVVSWGYGCAYSNYPGVYADV 242
            .|.|.:.|...||||.  ....|:||||||||||:.    ..|:|..|||.|||.:..||||.:|
Human   450 RYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNV 514

  Fly   243 AALRSWV 249
            .....|:
Human   515 MVFTDWI 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30025NP_725036.1 Tryp_SPc 30..249 CDD:214473 85/238 (36%)
TMPRSS2NP_001128571.1 LDLa 150..185 CDD:238060
SRCR_2 190..283 CDD:464747 5/11 (45%)
Tryp_SPc 293..524 CDD:238113 85/239 (36%)
Blue background indicates that the domain is not in the aligned region.

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