DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and Whrn

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	752	Identity:	125/752 - (16%)
Similarity:	235/752 - (31%)	Gaps:	261/752 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AETNQETASTTTTSTHCSTTGRRRKGGSLGGTLSSRSTRSESKELRSALQDREAVIQNLRIQLCL 110
            |:.:..:.|:::|.:..|.......||..|..|.|.:.|...:.|.:.|.:
Mouse     3 AQLDGLSVSSSSTGSLGSAAAAAGGGGGAGLRLLSANVRQLHQALTALLSE-------------- 53

  Fly   111 GKLPRPTGPPLDESEKPAAEQKLNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRIRQAELEYA 175
                            |..||..:.|  .|.:.|..:.:|              :|..:..|:..
Mouse    54 ----------------PEREQFTHCL--NAYHARRNVFDL--------------VRTLRVLLDSP 86

  Fly   176 LGREELQMLSIV---------EEARALQARLEKSKPEAQTLYNIISSG-------VSLSLHAVHA 224
            :.|..|.||.:|         ::..|....|..:.|..|..:......       |||.....|.
Mouse    87 VKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQPAWAAPDGAGPGEVRLVSLRRAKAHE 151

  Fly   225 TSGRWAVQQRTDQ-PGFYVEWA-----LEGDGLYKGDRILEINGRLVTGKSKEELQKQVGNSGKC 283
            ..| ::::..::. .|.||...     .|.:||..||:||.:|.:.:...:..|..|.:..|.|.
Mouse   152 GLG-FSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKL 215

  Fly   284 QMVVLRKKSVPIPQKQLDQEKENNMRLQHRISYLEEQVREL---QTVKEHHPSQQQQQQ------ 339
            .:.|.....:|           ......|..::::.|.|..   .::.:.|.|..:|::
Mouse   216 VLSVYSAGRIP-----------GGYVTNHIYTWVDPQGRSTSPPSSLPQPHGSTLRQREDDRRST 269

  Fly   340 -------QQQQQNPQQNPQQNPQQTSSNQSQHVTSISISS-PPSTPPEKPLIFQRGNYITTLVGG 396
                   .:::.|......::...|....:::...|.|:. .|.:..|...: :.|:.|..:.|.
Mouse   270 LHLLQSGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGL-KVGDQILEVNGR 333

  Fly   397 KPIELMGDDMASTQTPPGHVTKTLIKENTHIDL--RD--RLSHMYSM--PSKSLSASKI--SINS 453
            ..:.::.|:...           |:|.:.|:.|  :|  ||.|..:.  .:|.:::|:|  |:.:
Mouse   334 SFLNILHDEAVK-----------LLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESVAN 387

  Fly   454 DSAYMQHHRR-------------------------------DKERHRDRQHRERPRDPLQQQQQL 487
            .:.:...|..                               |:.||   ...|:.|..:......
Mouse   388 SAGFPGDHTEEGTSKPGFYKGPAGSQVTLSSLGNQTRALLDDQARH---LLTEQERATMMYYLAQ 449

  Fly   488 HRE-------------HLMSTHAR-----------SVEHLNHYNGLDRRRDTPRQSESNTLRARL 528
            :|.             .|::|||:           |.:.|:.::.|..||      |..:::||.
Mouse   450 YRGGTISVEAMVMALFELLNTHAKFSLLSEVRSIISPQDLDRFDHLVLRR------EIESMKARQ 508

  Fly   529 P--------------SDMRS-------------------------VKSLDFDSENES-------- 546
            |              ||..|                         ..:||.:...|:
Mouse   509 PPGPGVGDTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTGETTQGSTNAL 573

  Fly   547 ---------KPATETRTTRPTPPKKPLRLSLQRAQSLQTVELHPCADIERK------RPMKRVHH 596
                     .|:.:....:|.||..||      ||....:...|     ||      .|:....|
Mouse   574 PDVSVDDVKSPSEDLPGIKPPPPPPPL------AQGHDRLLGQP-----RKPGREDPAPLSSAAH 627

  Fly   597 N-------NNNNNKGGESPTGEGQTMLIENCSPMHTA 626
            :       .|.:...|.:||....:......||::.:
Mouse   628 SGIVFSAPRNRSPPPGTAPTPGPSSAQDSPSSPIYAS 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	12/40 (30%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822	17/120 (14%)
		PDZ_signaling	139..216	CDD:238492	20/77 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		5/25 (20%)
		PDZ_signaling	278..358	CDD:238492	14/91 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		1/19 (5%)
		HN_L-whirlin_R2_like	420..500	CDD:259823	15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824		20/116 (17%)
		PDZ_signaling	827..898	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900