Protein Alignment sprt and Dlg5

DIOPT Version :9

• Sequence 1: NP_610683.1
• Gene: sprt / 246397
• FlyBaseID: FBgn0082585
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: XP_017171686.1
• Gene: Dlg5 / 71228
• MGIID: 1918478
• Length: 1931
• Species: Mus musculus
• Alignment Length: 668
• Identity: 121/668 - (18%)
• Similarity: 205/668 - (30%)
• Gaps: 246/668 - (36%)

  Fly    78 LSSRSTRSESKELRSA--------------------LQDREAVIQNL-----RIQLCLGKLPRPT 117
            |.|..|...||::::|                    :.:|:.||..|     .::|...||...|
Mouse   400 LQSELTELRSKQVKTAKESEKYKEERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSST 464

  Fly   118 GPPLDESEKPAAEQKLNRLKTEAE---------NKRIKI---------KNLKSALEKLDIT---- 160
                  |||.||.:::..|:...:         ||.::|         :.||.||::.|:.
Mouse   465 ------SEKKAASEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRR 523

  Fly   161 ---------------------DNIDIRIRQ---AELEYALG------------REELQMLSIVEE 189
                                 ||:. |.|.   :||..||.            ..||:.|:....
Mouse   524 DWAFQERDKIVAERDSIRTLCDNLR-RERDRAVSELAEALRSLDDTRKQKNDVSRELKELNSCVH 587

  Fly   190 ARALQARLEKSKPEAQTLYNIISSGVSLSLH--AVHATSGRWAVQ-------------------- 232
            ...::.:|||.....|.:.:        |.|  |:...|..|..:
Mouse   588 REQMECQLEKEARFRQLMAH--------SSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDM 644

  Fly   233 -QRTDQP------GFYVEWALEG---DG-LYKGDRILEING-RLVTGKSKEELQKQVGNSGKCQM 285
             :..::|      |.:|....:|   || |...|.:|.||. .|:....|:.::..:...|...|
Mouse   645 AEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINM 709

  Fly   286 VVLRKKSVPIPQKQLDQEKENNMRLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNP 350
            ||.|:||:
Mouse   710 VVRRRKSL--------------------------------------------------------- 717

  Fly   351 QQNPQQTSSNQSQHVTSISIS---SPPSTPPEKPLIFQRGNYITTLVGGKPIE-----LMGDDMA 407
                      ..:.||.:.|:   ...|.|.:..:..:.|.|...:|.|.|..     .:||.:.
Mouse   718 ----------GGKVVTPLHINLSGQKGSRPQDSGISLENGVYAAAVVPGSPAAKEGSLAVGDRIV 772

  Fly   408 STQTPPGHVTKTLIKENTHIDLRDRLSHMYSMPSKSLSASKISINSDSAYMQH---HRRDKER-- 467
            :        ...:..:|..::..:.|... ...|.:||..|:...|.|...|:   :.:|.:|
Mouse   773 A--------INGIALDNKSLNECESLLRS-CQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDRML 828

  Fly   468 ----HRDRQHRERPRDPLQQQQQLHREHLMSTHARSVEHLNHYNGLDRRRDTPRQSESNTLRAR- 527
                |.........|:.||.......:...:......:.|.|..|.......|....|:.:..:
Mouse   829 SCRAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVSPQA 893

  Fly   528 LPS-DMRSVKSLDFDSENE-SKPATETRTTRPTPPKKPLRLSLQRAQSLQTVELHPCADIERKRP 590
            .|| ..||:.|...|:..| .....:.|:.||.       ||.:       .|:.||..:|  .|
Mouse   894 CPSTSERSLNSFRSDTSAERGYGLVDMRSQRPL-------LSFE-------TEVGPCGAVE--VP 942

  Fly   591 MKRVHHNNNNNNKGGESP 608
            :.::  :...:|.||..|
Mouse   943 LDKI--DPEGSNSGGTWP 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	13/45 (29%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117	36/170 (21%)
		PDZ_signaling	625..712	CDD:238492	16/86 (19%)
		PDZ_signaling	<741..800	CDD:238492	10/67 (15%)
		PDZ	1357..1439	CDD:214570
		dbPDZ_assoc	1437..1512	CDD:374667
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900