DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sprt and lnx1

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	422	Identity:	90/422 - (21%)
Similarity:	147/422 - (34%)	Gaps:	120/422 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SAHHRAFAKQKSAS-------------MTILNPKGCGSA-----------VKYSLHSTAETNQET 52
            ::|:...|::|..|             :..|..:||.|:           |..:...:.|.|.::
Zfish   147 ASHYGLSAERKRRSQEGDCTDSTSELTLAALPGEGCPSSAIALLSDEPGLVNPAYEPSVEDNSQS 211

  Fly    53 ASTTT-----------------TSTHCSTTGRRRKGGSL-----GGTLSSRSTRSESKELRSALQ 95
            .|||:                 ||....:..|..:..|:     .||..:..|..|...||:|
Zfish   212 GSTTSLAARSGSRKSEYRNFDRTSVRSRSFRRLNRAFSVLRRTKSGTAVANDTTEERDNLRNA-- 274

  Fly    96 DREAVIQNLRIQLCLGKLPR-----PTG-------------PPLDES-----EKPAAE---QKLN 134
                   |:..:..|..||:     |.|             .||..|     |.|...   |.:.
Zfish   275 -------NIPAEGELFALPQLHHLIPDGEVTSIKITRADPCEPLAISIVGGNETPLVRILIQDIY 332

  Fly   135 RLKTEAENKRIKIKNLKSALEKLDITDNIDIRIRQAELEYALGREELQMLSIVEEARALQARLEK 199
            |....|.:.|:...::...:..:||: |:......|.|:...   .|..|:::.|.|........
Zfish   333 REGVIARDGRLLPGDMILKVNGIDIS-NVPHCYAVAALKQPC---TLLRLTVLREQRHRYRSHHH 393

  Fly   200 SKPEAQTLYNIISSGVSLSLHAV---HATSGRWAVQ--QRTDQPGFYVEWALEG-----DG-LYK 253
            |..||...:.  ::....|||.|   .|...:..::  :|.|:.|.::...|||     || |..
Zfish   394 SPTEAFPAHT--ATIRDDSLHVVLVKRAPDEQLGIKLVRRPDEHGVFIFHLLEGGLAARDGRLRV 456

  Fly   254 GDRILEINGR-LVTGKSKEELQKQVGNSGKCQMVVLRKKSVPIPQKQLDQEKENNMR-------- 309
            .||:|.|||. |..|..:........:..:...:|.|:..:|.|  .:.||...||.
Zfish   457 DDRVLAINGHDLRYGAPEHAALLIQASEDRVHFIVSRQTHIPAP--DILQEAPWNMEGPPPYSPV 519

  Fly   310 -LQHRI-------SYLEEQVRELQTVKEHHPS 333
             ::|.:       :..|:.|..|   ||.|.|
Zfish   520 DIEHTLLDSCQKPACYEKTVTLL---KEPHDS 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	13/47 (28%)
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492	16/87 (18%)
		PDZ_signaling	411..491	CDD:238492	21/79 (27%)
		PDZ_signaling	536..621	CDD:238492	7/16 (44%)
		DegQ	<548..621	CDD:223343	1/1 (100%)
		PDZ_signaling	678..762	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900