DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and a

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	148/727 - (20%)
Similarity:	247/727 - (33%)	Gaps:	179/727 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KQKSASMTILNPKGCGSAVKYSLHSTAETNQETASTTTTSTHCSTTGRRRKGGSLGGTLSS---- 80
            :|:...:..|....|....|.|...||.|:..:|:.:..|...|...    ||  |||.:|
  Fly   527 EQRLPRIASLKSSSCDDIAKVSSCLTASTSSGSAAGSLGSPPSSAAA----GG--GGTANSGQHD 585

  Fly    81 ------------RSTRSESKE---------LRSALQ-DREAVIQNLRIQLCLGKLPRPTGPPLDE 123
                        ||..|...|         |:..:| .||...|:.|..|    ....|..||.:
  Fly   586 PSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQHQRDLL----QQEQTSSPLPQ 646

  Fly   124 SEKPAAEQKLNRLKTEAENKRIKIKNLKSALEKLD--------------------ITDNIDIRIR 168
            ...|  ||.:  |...:.|..|..|:.:...::|.                    :.:|:.|...
  Fly   647 RRSP--EQAM--LNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLSISGG 707

  Fly   169 QAE--------------------------LEYALGREELQMLSIVE------------EARALQA 195
            ..|                          :...||....:..||..            |...::.
  Fly   708 DTESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRR 772

  Fly   196 RLEKSKPEAQTLYNIISSGVSLSLHAVHATSGRWAVQQRTDQPGFYVEWALEGDGLYK------- 253
            |..:.|.|.:...:.|  |:.||...|...|        .:|...|:...||..|:.:
  Fly   773 RFRQVKLERKCQEDYI--GIVLSPKTVMTNS--------NEQQYRYLIVELEPYGMAQKDGRLRL 827

  Fly   254 GDRILEINGRLVTG-KSKEELQKQVGN-SGKCQMVVLRKKSVPIPQKQLDQEKENNMRLQ-HRIS 315
            ||.|:.:||:.:.| :|..|:|:.:.: ...|..:|:....|........:.:.:.|..| ||:|
  Fly   828 GDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLS 892

  Fly   316 YLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSISISSPP------ 374
            |::      :|......|..|..|.||::....|.:|..:....:|....:..|:|:.|
  Fly   893 YVQ------RTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLM 951

  Fly   375 -----STP--------PEKPLIFQR-----GNYITTLVGGKPIELMGDDMASTQTPPGHVTKTLI 421
                 |||        ||..|:.:|     |.....|.   |..|.....:|..:.|.|  :.|.
  Fly   952 QHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALT---PTPLFASGSSSCSSSPNH--RLLD 1011

  Fly   422 KENTHIDLRDRLSHMYSMPSKSLSASKISINSDSAYMQHHRRDKERHRDRQHRERPRDPLQQQQQ 486
            .||...:..|..:.:|:..:.|:..:. |:..|..:....|:   |..:........:|.|..|:
  Fly  1012 NENDPANDTDSYTPVYANRAASVCVAS-SLADDEKWQLLARK---RCSEGSALSATPNPQQFGQR 1072

  Fly   487 LHREHLMSTHARSVEHL--NHYNGLDRRRDTPRQSESNTLRARLPSDMRS-VKSLDFDSENESKP 548
            .|       :||:..:|  :||..|       |.:.|....:||...|:: ..||.......:.|
  Fly  1073 TH-------YARNSINLANSHYRSL-------RFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTP 1123

  Fly   549 -ATETRTTRPTPPKKPLRLSLQRAQSLQTVELHPCADIERKRPMKRVHHNNNNNNKGGESPTGEG 612
             :|.|.||..|..::..:...|..|||..........:....|    :.|.:::.....:..|.|
  Fly  1124 SSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNP----YVNASSSPASASTSAGAG 1184

  Fly   613 QTMLIENCSPMH 624
            .::.....:.||
  Fly  1185 SSLAPPAAALMH 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	12/49 (24%)
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	24/99 (24%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900