DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and loco

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	114/553 - (20%)
Similarity:	202/553 - (36%)	Gaps:	137/553 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PRP-TGPPLDESEKP----AAEQKLNRLKTEAENKRIKI------KNLKSALEKLDITDNIDIRI 167
            |.| :|..|||..|.    .|..||.:..:.||::|.|.      |....:.::.:|
  Fly   951 PLPYSGLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEI-------- 1007

  Fly   168 RQAELEYALGREELQMLSIVEEARALQARLEKSKPEAQTLYNIISSGVSL-SLHAVHATSGRWAV 231
             .|::::||    :....:.:.|....|.| |......:|.::.||..|| |..|..||.|:.|
  Fly  1008 -MADMQHAL----MPAPPVPQNAPLTSASL-KLVCGQNSLSDLHSSRSSLSSFDAGTATGGQGA- 1065

  Fly   232 QQRTDQPGFYVEWALEGDGLYKGDRILEINGRLVTGKSKEELQKQVGNS-GKCQMVVLRKKSVPI 295
                           ..:.:|...|::..:|....      :|.:.|.: |:....:|.|:::..
  Fly  1066 ---------------STESVYSLCRVILTDGATTI------VQTRPGETVGELVERLLEKRNLVY 1109

  Fly   296 P---------QKQLDQEKENNMR------LQHRISY-------------------LEEQVRELQT 326
            |         .|.:|.::.:.:.      ::.|:::                   |.|.:|.:.:
  Fly  1110 PYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILS 1174

  Fly   327 VKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSIS--------ISSPP-STPPEKPL 382
             |.::..:|.|...:..|.|....|  |...:..|...:..::        .|.|| .:.|.|||
  Fly  1175 -KYNYKMEQVQVIMRDTQVPIDLNQ--PVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPL 1236

  Fly   383 IFQRGNYITTLVGGKPIELMGDDMASTQTPPGHVTKTLIKEN----THIDLRDRLSHMY----SM 439
            .....:.:|..|..:.:....|..||.::.|  |....:|.|    ....|.:|:....    ::
  Fly  1237 PQGHLDELTNKVFNELLASKADAAASEKSRP--VDLCSMKSNEAPSETSSLFERMRRQQRDGGNI 1299

  Fly   440 PSKSLSASKISINSDSAYMQHHRRDKERHRDRQHRERPRDP----------LQQQQQL--HREHL 492
            |:..|...|....|.|       :..|.....|....|:.|          ||..:::  |::.|
  Fly  1300 PASKLPKLKKKSTSSS-------QQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDEL 1357

  Fly   493 MSTHARS-VEHLNHYNGLDRRRDTPRQSESNTLRARLPSDMRSVK-SLDFDSENESKPATETRTT 555
            :....|: :..|....|.:...|.|...::....:...|.:|.|: ||   |.....|||.|...
  Fly  1358 LEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRKVRASL---SPVSKVPATPTEIP 1419

  Fly   556 RPTPPKKPLRLSLQRAQ---SLQTVELHPCADI 585
            :|.|     |||:.|:|   |...|:..|..|:
  Fly  1420 QPAP-----RLSITRSQQPVSPMKVDQEPETDL 1447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	6/41 (15%)
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412	11/77 (14%)
		RBD	1144..1213	CDD:128731	11/71 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900