DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and bbg

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	137/798 - (17%)
Similarity:	248/798 - (31%)	Gaps:	314/798 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVSEPISAHH---RAFAKQKSAS--------------MTILNPKGCGSAVK--------YSLHST 45
            ::||||:..|   |..::||:.|              :|..|.|...:..|        ..|...
  Fly   889 ILSEPITTIHEERRVLSEQKTLSESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLLDLGDE 953

  Fly    46 AETNQE--TASTTTTST-----HCSTTGRRRKGGSLGGTLSSRSTRSESKE-----LRSALQDRE 98
            .:..::  ||:.|..|:     .|....:....|:|  |||.|..:...||     ......::|
  Fly   954 QDMQEQPLTATITQESSLRERLECPQDNQSIDRGTL--TLSERGKQLSEKEGLTTYTECETSEKE 1016

  Fly    99 AVIQNLRIQLCLGKLPRPTGPPLDESEKPAAEQKLNR------------LKTEAENKRIKIKNLK 151
            :.::..::....|......    :.|::|..|::::.            .|...:||.|..|...
  Fly  1017 SYLEGQQVLNGKGGFVSQD----ENSDQPTYEREVSETLTIVNDGEKQVTKKLEQNKEIAGKKGA 1077

  Fly   152 SALEKLDITDNIDIRIRQAELEYALGREELQMLSIVEEARALQARLEKSKPEAQTLYNIISSGVS 216
            ..|:|.|         .:..||              :||:.|....:|.|.||:.||.:
  Fly  1078 KLLKKTD---------EERRLE--------------QEAQKLIESYQKVKKEAEKLYKL------ 1113

  Fly   217 LSLHAVHATSGRWAVQQRTDQPGFYV---EWALEGDGLYKGDRILEING---------------- 262
                           :...|..||.:   |.|.|.|.....:.|.|:..
  Fly  1114 ---------------ELADDDQGFDLSAFEQAEEEDKPEVSEEIKEVKDSQPVKVDIQIEEEVKT 1163

  Fly   263 -RLVTGKSK-EELQKQVGNSGKCQMVVLRKKSVPIPQ-------KQLDQEKENNMRL---QHRIS 315
             ..|.|:.| |::.|::..:.:.....: ||.|.:..       |..::::.|.:::   :.:::
  Fly  1164 PNQVIGEVKVEDVNKEIKETVQVSQQEI-KKEVKVSHQETKETFKSEEKDESNELKIVKEEVKVT 1227

  Fly   316 Y--LEEQVRELQTVKEHH---------------PSQQQ--------------------------- 336
            :  |.||::|::.||..|               .|.:|
  Fly  1228 HQDLREQIQEIEAVKVVHKEVKVIKESAKVTTTTSHKQATKEVIISKEDHKNDSALPAVSTTKVE 1292

  Fly   337 ---------------------QQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSISISSPPSTPPEK 380
                                 |::.:....|...|:..|...::....   .::::.|.|.||
  Fly  1293 IISPPLEDDLGYVLHKHIIFPQEKVKTAPTPLPKPKPKPPVPTNKPKM---PVNLTKPKSAPP-- 1352

  Fly   381 PLIFQRGNYITTLVGGKPIELMGDDMASTQTPPGHVTKTLIKENTHIDLRDRLSHMYSMPSK--- 442
            |:..:|.....:  ||||..........|..||..:.:.::    .::.||.       |.|
  Fly  1353 PVPSKRSELSGS--GGKPTPTQRRGSLETAQPPKPLERIIV----GVEQRDE-------PEKPQP 1404

  Fly   443 -----SLSASKISINSDSAYMQHHRRDKERHRDRQHRERPRDPLQ-----------QQQQLHREH 491
                 |:....::.||..|.::          .....|.|.|.||           :::.||:|.
  Fly  1405 IINLASVDLPNVAPNSKQATVE----------TTPVVEMPPDELQFESHQLPDDGEKEKDLHQES 1459

  Fly   492 ---LMSTHARSV--------------------EHLNHYNGL----------DRRRDTPRQSESNT 523
               |..:.:.||                    ..:...||:          |...:.....:...
  Fly  1460 NDLLSGSSSSSVTTPITTPILVSATSSMDSVQSVIEVVNGMPIISNQQTDDDDIDEVAAYDDGMH 1524

  Fly   524 LRARLPSDMRSVK---SLDFDSENES-----------------------------------KPAT 550
            |.|....|:|.|:   :|..|.|:||                                   |.:|
  Fly  1525 LEAEGTKDVRPVQEVTTLTLDREHESDLGTLSNHHSNISSISGINASSNIPAATLISSSIKKTST 1589

  Fly   551 ETRTTRPTPPKKPLRLSL 568
            |..||:|..|:.|.::.|
  Fly  1590 EAATTKPAAPQIPGKMEL 1607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	9/58 (16%)
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375	10/47 (21%)
		PDZ_signaling	2331..2413	CDD:238492
		PDZ_signaling	2553..2634	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900