DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and Lnx1

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	114/567 - (20%)
Similarity:	174/567 - (30%)	Gaps:	225/567 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AHHRAFAKQKSASMTILNPKGCGSAVKYSLHSTAETNQETASTT---------------TTS--- 59
            |.|....|.:........|.||.     ||.:|..:.:.:|:.|               |:|
  Rat   135 ASHYGLTKDRKRRSQDGCPDGCA-----SLTATTLSPEVSAAATISLMTDEPGLDNPAYTSSVED 194

  Fly    60 ----THCSTTGRRRKGGSLGGTLSSRSTRSESKELRSALQDREAVIQNLRIQLCLGKLPR-PTGP 119
                |:.|.|||            |..||:...| ||.::.|..    .:|...|..|.| .:|.
  Rat   195 GEPVTNPSDTGR------------SNRTRARPFE-RSTMRSRSF----KKINRALSALRRTKSGS 242

  Fly   120 PL--------DESEK---PAAEQKLNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRI------ 167
            .:        |.||.   |....:|..|..:.|...|||       .::|..:::.||:
  Rat   243 AVANHADQGRDNSENDTVPEVFPRLFHLIPDGEITSIKI-------NRVDPNESLSIRLVGGSET 300

  Fly   168 -----------------RQAEL-------------------EYA--LGREELQM--LSIVEEAR- 191
                             |...|                   .||  |.|:..|:  |:::.|.:
  Rat   301 PLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKF 365

  Fly   192 -----------------ALQARLEKSKPEAQTLYNIISSGVSLSLHAVHATSGRWAVQQRTDQPG 239
                             :....|.||.||.|.       |:.|              .:|.|:||
  Rat   366 RSRSNAPAPDSYGPRDDSFHVILNKSSPEEQL-------GIKL--------------VRRVDEPG 409

  Fly   240 FYVEWALEG------DGLYKGDRILEINGRLVTGKSKEELQKQVGNSGKCQMVVLRKKSVPIPQK 298
            .::...|.|      ..|.:.||:|.|||..:...|.|.                        ..
  Rat   410 VFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPES------------------------AA 450

  Fly   299 QLDQEKENNMRLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQ 363
            .|.|..|..:.|     .:..|||:        ||....|:.....|.||:|....:.||
  Rat   451 HLIQASERRVHL-----VVSRQVRQ--------PSPDIFQEAGCISNGQQSPVSGERSTS----- 497

  Fly   364 HVTSISISSPPSTPPEKPLIFQR--GNYITTLVGG--------KPIELMGDDMASTQTPPGHVTK 418
                   |.|.:|..||.:..|:  ...:...|||        .||.::..:.....:..|.: |
  Rat   498 -------SKPAATCHEKVVSVQKDPNESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRI-K 554

  Fly   419 T---LIKEN----THIDLRDRLSHMYSMPS----KSLSASKISINSD 454
            |   |:..|    |.:...:.::.:.|.||    |:|...:.....|
  Rat   555 TGDILLNVNGIELTEVSRTEAVAILKSTPSSVVLKALEVKEQETQED 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	10/46 (22%)
Lnx1	NP_001101828.1	RING	45..81	CDD:214546
		DegQ	<260..364	CDD:223343	19/110 (17%)
		PDZ_signaling	276..360	CDD:238492	14/90 (16%)
		PDZ_signaling	384..464	CDD:238492	27/129 (21%)
		PDZ_signaling	506..589	CDD:238492	17/83 (20%)
		PDZ_signaling	637..721	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900