DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sprt and Lnx2

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	92/441 - (20%)
Similarity:	145/441 - (32%)	Gaps:	156/441 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 CLGKLPRPTG------------PPLDE---SEKPAAEQKLNRLK-TEAENKRIKIKNLKSALEKL 157
            |||.:|....            |.||.   .|..||:.....|. .|.|...|:|......:: |
  Rat   181 CLGTVPGERNSTPAPLPVWTEDPGLDNPAFEESAAADSVQQPLSLPEGEITTIEIHRTNPYIQ-L 244

  Fly   158 DI-------TDNIDIRIRQAELEYALGREEL-----QMLSI----VEEARALQARLEKSKPEAQT 206
            .|       |..|:|.|::...:.|:.|:..     |:|.:    :.......||...|:| ..|
  Rat   245 GISIVGGNETPLINIVIQEVYRDGAIARDGRLLAGDQILQVNNCDISNVSHNYARAVLSQP-CST 308

  Fly   207 LYNII----SSGVSLSLHA-------------VHATSGRWAVQQ-------RTDQPGFYVEWALE 247
            |:..:    ..|...:.||             :|.   |.:.:|       |||:||.::...||
  Rat   309 LHLTVLRERRFGSRANNHADGSAPRDEVFQVLLHK---RDSAEQLGIKLVRRTDEPGVFILDLLE 370

  Fly   248 G-----DG-LYKGDRILEINGRLVTGKSKEELQKQVGNSG-KCQMVVLRKKSVPIPQKQLDQEKE 305
            |     || |...||:|.|||..:...:.|.....:..|| :..:.:.|      |.|
  Rat   371 GGLAAQDGRLSSNDRVLAINGHDLKQGTPELAAHIIQASGERVNLTIAR------PGK------- 422

  Fly   306 NNMRLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSISI 370
                                                    ||  |....::..::.|.|....|.
  Rat   423 ----------------------------------------PQ--PSNGSREAGAHSSNHAQPPSH 445

  Fly   371 SSPPSTPPEKPLIFQRGNYITTLVGGKPIELMGDDMAS-------------TQTPP-------GH 415
            |.|.|.......:..:..:||  |..:|.|.:|..:|.             |..||       |.
  Rat   446 SRPSSHKDLTRCVTCQEKHIT--VKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGR 508

  Fly   416 VTKTLIKENTH-IDLRDRLSHMYSM---------PSKSLSASKISINSDSA 456
            :.:..:..|.: |||.: |||..::         |:..|.|.::.|..::|
  Rat   509 IKRGDVLLNINGIDLTN-LSHSEAVAMLKASAASPAVILKALEVQIAEEAA 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	14/47 (30%)
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	19/87 (22%)
		PDZ	335..421	CDD:214570	24/94 (26%)
		PDZ_signaling	462..538	CDD:238492	18/78 (23%)
		PDZ_signaling	595..679	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900