DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and Whrn

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_038965801.1	Gene:	Whrn / 313255	RGDID:	631330	Length:	969	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	123/731 - (16%)
Similarity:	230/731 - (31%)	Gaps:	248/731 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AETNQETASTTTTSTHCSTTGRRRKGGSLGGTLSSRSTRSESKELRSALQDREAVIQNLRIQLCL 110
            |:.:..:.|:::|.:..|.......||..|..|.|.:.|...:.|.:.|.:
  Rat     3 AQLDGLSVSSSSTGSLGSAAAAAGGGGGAGLRLLSANVRQLHQALTALLSE-------------- 53

  Fly   111 GKLPRPTGPPLDESEKPAAEQKLNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRIRQAELEYA 175
                            |..||..:.|  .|.:.|..:.:|              :|..:..|:..
  Rat    54 ----------------PEREQFTHCL--NAYHARRNVFDL--------------VRTLRVLLDSP 86

  Fly   176 LGREELQMLSIV---------EEARALQARLEKSKPEAQTLYNIISSG-------VSLSLHAVHA 224
            :.|..|.||.:|         ::..|....|..:.|..|..:......       |||.....|.
  Rat    87 VKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQPAWAAPDGAGPGEVRLVSLRRAKAHE 151

  Fly   225 TSGRWAVQQRTDQ-PGFYVEWA-----LEGDGLYKGDRILEINGRLVTGKSKEELQKQVGNSGKC 283
            ..| ::::..::. .|.||...     .|.:||..||:||.:|.:.:...:..|..|.:..|.|.
  Rat   152 GLG-FSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKL 215

  Fly   284 QMVVLRKKSVPIPQKQLDQEKENNMRLQHRISYLEEQVREL---------QTVKEHHPSQQQ--- 336
            .:.|.....:|           ......|..::::.|.|..         .|:::|...::.
  Rat   216 VLSVYSAGRIP-----------GGYVTNHIYTWVDPQGRSTSPPSSLPHGSTLRQHEDDRRSALH 269

  Fly   337 --QQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSISISS-PPSTPPEKPLIFQRGNYITTLVGGKP 398
              |...:::.|......::...|....:::...|.|:. .|.:..|...: :.|:.|..:.|...
  Rat   270 LLQSGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGL-KVGDQILEVNGRSF 333

  Fly   399 IELMGDDMASTQTPPGHVTKTLIKENTHIDL--RD--RLSHMYSM--PSKSLSASKI--SINSDS 455
            :.::.|:...           |:|.:.|:.|  :|  ||.|..:.  .:|.:::|:|  ||.:.:
  Rat   334 LSILHDEAVK-----------LLKSSRHLILTVKDVGRLPHARTTVDQTKWIASSRIGESITNSA 387

  Fly   456 AY---------------------------MQHHRR----DKERHRDRQHRERPRDPLQQQQQLHR 489
            .:                           :.:..|    |:.||   ...|:.|..:......:|
  Rat   388 GFPGDLTEEGTNKPGFYKGPAGSQVTLSSLGNQTRALLDDQARH---LLTEQERATMMYYLDQYR 449

  Fly   490 E-------------HLMSTHAR-----------SVEHLNHYNGLDRRRDTPRQSESNTLRARLP- 529
            .             .|::|||:           |.:.|:.::.|..||      |..:::||.|
  Rat   450 GGTISVEALVMALFELLNTHAKFSLLSEVRGIISPQDLDRFDHLVLRR------EIESMKARQPP 508

  Fly   530 -------------SDMRS-------------------------VKSLDFDSENES---------- 546
                         ||..|                         ..:||.:...|:
  Rat   509 GPGVGDTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTGETTQGSTNALPD 573

  Fly   547 -------KPATETRTTRPTPPKKPLRLSLQR--AQSLQTVELHPCADIERKRPMKRVHHN----N 598
                   .|:.:....:|.||..||.....|  .|:.:.|.       |...|:....|:    :
  Rat   574 VSVDDVRSPSEDLPGIKPPPPPPPLAQGHDRLLGQTRKPVR-------EDSAPLSSAAHSGIVFS 631

  Fly   599 NNNNKGGESPTGEGQT 614
            ...|:....|.|...|
  Rat   632 APRNRSPPPPPGIAPT 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	12/40 (30%)
Whrn	XP_038965801.1	HN_L-whirlin_R1_like	38..113	CDD:259822	17/120 (14%)
		PDZ_signaling	139..216	CDD:238492	20/77 (26%)
		PDZ_signaling	276..356	CDD:238492	14/91 (15%)
		HN_L-whirlin_R2_like	418..498	CDD:259823	16/88 (18%)
		PDZ_signaling	<908..949	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900