Protein Alignment sprt and Grip2

DIOPT Version :9

• Sequence 1: NP_610683.1
• Gene: sprt / 246397
• FlyBaseID: FBgn0082585
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_612544.2
• Gene: Grip2 / 171571
• RGDID: 621668
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 571
• Identity: 117/571 - (20%)
• Similarity: 198/571 - (34%)
• Gaps: 122/571 - (21%)

  Fly    73 SLGGTLSSRSTRSESKE-LRSALQDREAVIQNLRIQLCLG------------KLPRPTGPPLDES 124
            ::.|..:...|..|:.: ||.|...|:.|   |.|:..:.            |||:..|..|..:
  Rat   512 AINGIATEDGTMEEANQLLRDAALARKVV---LEIEFDVAESVIPSSGTFHVKLPKRRGVELGIT 573

  Fly   125 EKPAAEQKLNRLKTEAENKRIKIKNLKSALE---KLDITDNIDIRIRQAELEYALGREELQMLSI 186
            ...|:.::...| ..::.|:..:.:....||   ||...||  ||:....:|||     :|:|..
  Rat   574 ISSASRKRGEPL-IISDIKKGSVAHRTGTLEPGDKLLAIDN--IRLDHCPMEYA-----VQILRQ 630

  Fly   187 VEEARALQARLEKSKPEAQTLYNIISSGVSLSLHAVHATSGRWAVQ-QRTDQP-------GFYVE 243
            .|:...|:.|.::...:.|.....:|..|.|..:     .|...:. ..|::|       |....
  Rat   631 CEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRY-----GGPLGITISGTEEPFDPIIISGLTKR 690

  Fly   244 WALEGDG-LYKGDRILEINGRLVTGKSKEELQKQVGNSGKCQMVVLRKK-SVPIPQKQ------- 299
            ...|..| ::.|||||.||...:.|:...|....:..:|:...:.::|: ..|:..:|
  Rat   691 GLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEA 755

  Fly   300 --LDQEKENNMRLQHRISYLEEQVRELQTVKEHHPSQQQQQ--QQQQQQNPQQNPQQ-NPQQTSS 359
              :|::....::.....::....|..:.:..|...|...:.  .......||...:. .||:..|
  Rat   756 SDVDEDPPEALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEWRS 820

  Fly   360 NQSQHVTSISISSPPSTPPEKPLIFQRGNYITTLVGGK-----PIELMGDDMASTQTPPGHVTKT 419
            ::.:       ||||...|.:          |:...|.     |.|..||........||...:.
  Rat   821 SRLK-------SSPPPLEPRR----------TSYTPGPTDESFPEEEEGDWEPPMSPAPGPAREE 868

  Fly   420 LIKENTHIDLRDRLSHMYSMPSKSLSASKISINSDSAYMQHHRRDKERHRDRQHRERPRD----- 479
            .........|.|..|...|...:.|.||.::....|..:......:...|.|:....|.|
  Rat   869 GFWRVLGEALEDLESCGQSELLRELEASIMTGTVQSVAVDGRPGSRPWRRSREVGTSPEDLQELL 933

  Fly   480 ---PLQQQQ-QLHREHLMSTHARSVEHLNHYNGL--------DRRRDTPRQSESNTLRARLPSDM 532
               ||:..: .||::.:.:....||.     :||        ..|.|.|.|........|| ..:
  Rat   934 LPTPLEMHRVTLHKDPVRNDFGFSVS-----DGLLEKGVYVHTVRIDGPAQHGGLQPFDRL-LQV 992

  Fly   533 RSVKSLDFD-------------------SENESKPATETRTTRPTP-PKKP 563
            ..|::.|||                   |.|   |..::|.|...| |..|
  Rat   993 NHVRTRDFDCCLAVPLLAEAGDILELVVSRN---PLAQSRRTPGAPGPSSP 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	12/41 (29%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492
		PDZ_signaling	251..334	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..450
		PDZ_signaling	456..544	CDD:238492	9/34 (26%)
		PDZ_signaling	557..640	CDD:238492	23/90 (26%)
		PDZ_signaling	657..737	CDD:238492	18/84 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..769		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	786..863		18/93 (19%)
		PDZ_signaling	941..1020	CDD:238492	16/84 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900