Protein Alignment sprt and Lnx1

DIOPT Version :9

• Sequence 1: NP_610683.1
• Gene: sprt / 246397
• FlyBaseID: FBgn0082585
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_001153049.1
• Gene: Lnx1 / 16924
• MGIID: 1278335
• Length: 728
• Species: Mus musculus
• Alignment Length: 558
• Identity: 107/558 - (19%)
• Similarity: 170/558 - (30%)
• Gaps: 207/558 - (37%)

  Fly    13 AHHRAFAKQKSASMTILNPKGCGSAVKYSLH---STAET-----------------NQETASTTT 57
            |.|....|.:........|.||.|.:..:|.   |.|.|                 :.|......
Mouse   135 ASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDGEPVA 199

  Fly    58 TSTHCSTTGRRRKGGSLGGTLSSRSTRSESKELRSALQDRE--AVIQNLRIQLCLGKLPRPTGPP 120
            .|:....:.|.|.......|:.|||.:..::.| |||:..:  :|:.|   .:..|:
Mouse   200 NSSDSGRSNRTRARPFERSTMRSRSFKKINRAL-SALRRTKSGSVVAN---HVDQGR-------- 252

  Fly   121 LDESEK---PAAEQKLNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRI--------------- 167
             |.||.   |....:|..|..:.|...|||       .:.|.::::.||:
Mouse   253 -DNSENTTVPEVFPRLFHLIPDGEITSIKI-------NRADPSESLSIRLVGGSETPLVHIIIQH 309

  Fly   168 --------RQAEL-------------------EYA--LGREELQM--LSIVEEAR---------- 191
                    |...|                   .||  |.|:..|:  |:::.|.:
Mouse   310 IYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAHVP 374

  Fly   192 --------ALQARLEKSKPEAQTLYNIISSGVSLSLHAVHATSGRWAVQQRTDQPGFYVEWALEG 248
                    :....|.||.||.|.       |:.|              .:|.|:||.::...|.|
Mouse   375 DSYGPRDDSFHVILNKSSPEEQL-------GIKL--------------VRRVDEPGVFIFNVLNG 418

  Fly   249 ------DGLYKGDRILEINGRLVTGKSKEELQKQVGNSGKCQMVVLRKKSVPIPQKQLDQEKENN 307
                  ..|.:.||:|.|||..:...|.|.                        ...|.|..|..
Mouse   419 GVADRHGQLEENDRVLAINGHDLRFGSPES------------------------AAHLIQASERR 459

  Fly   308 MRLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQ--HVTSISI 370
            :.|     .:..|||:        .|....|:.....|.||:|....:.|:|..:.  |...:|:
Mouse   460 VHL-----VVSRQVRQ--------SSPDIFQEAGWISNGQQSPGPGERNTASKPAATCHEKVVSV 511

  Fly   371 SSPPSTPPEKPLIFQRGNYITTLVGG--------KPIELMGDDMASTQTPPGHVTKT---LIKEN 424
            ...||            ..:...|||        .||.::..:.....:..|.: ||   |:..|
Mouse   512 WKDPS------------ESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRI-KTGDILLNVN 563

  Fly   425 ----THIDLRDRLSHMYSMPS----KSLSASKISINSD 454
                |.:...:.::.:.|.||    |:|...:.....|
Mouse   564 GIELTEVSRTEAVAILKSAPSSVVLKALEVKEQEAQED 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	10/46 (22%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..220		4/34 (12%)
		NPXY motif	185..188		0/2 (0%)
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244		12/58 (21%)
		PDZ_signaling	276..360	CDD:238492	14/90 (16%)
		PDZ_signaling	384..464	CDD:238492	27/129 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..500		6/18 (33%)
		PDZ_signaling	506..589	CDD:238492	17/95 (18%)
		PDZ_signaling	637..721	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900