DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and Il16

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001347016.1	Gene:	Il16 / 16170	MGIID:	1270855	Length:	1424	Species:	Mus musculus

Alignment Length:	774	Identity:	139/774 - (17%)
Similarity:	223/774 - (28%)	Gaps:	302/774 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASMTILNPKGCGSAVKYSLHSTAETNQETASTTTTSTHC---------STTGRRRKGGSLGGTLS 79
            :||.:.:....|.:....|...:::.|..|:.:....||         |:|..:.|.|......|
Mouse   161 SSMQLADTFEAGLSNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSGKPEAQSS 225

  Fly    80 S--------RSTRSESKELRSALQDREAVIQNLRIQLCLGKLPRPTG----PPLDESEKPAAEQK 132
            |        :.|||.|..:.                      |...|    |...:|..|...|.
Mouse   226 SFLFPKACHQRTRSNSTSVN----------------------PYSAGEIDFPMTKKSAAPTDRQP 268

  Fly   133 LNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRIRQAELEYALGREELQMLSIVEEARALQ-AR 196
            .:           ...|.||..::||                      ..:|......|:|. |:
Mouse   269 YS-----------LCSNRKSLSQQLD----------------------YPILGTARPTRSLSTAQ 300

  Fly   197 LEKSKP--EAQTLYNII-----SSGVSLSLHAVHATSGRWAVQQRTDQPGFYVEWALEG-----D 249
            |.:...  :|..:.||:     :.|:..|:     ..|:.::.   ...|.||:....|     |
Mouse   301 LGQLSGGLQASVISNIVLMKGQAKGLGFSI-----VGGKDSIY---GPIGIYVKSIFAGGAAAAD 357

  Fly   250 G-LYKGDRILEINGRLVTGKSKEE-LQK-QVGNSGKCQMVVLRKKSVP----------------- 294
            | |.:||.|||:||..:.|.:.:: ||| :....|...:.|..:.:.|
Mouse   358 GRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSS 422

  Fly   295 --------------IPQKQLDQEKENNMRLQHRIS------------------------------ 315
                          .|.......|. |.|:...:|
Mouse   423 STCGAQDSSPFSLESPASPASTAKP-NYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTL 486

  Fly   316 ------YLEEQVR-------------------ELQTVKEH------------HPSQQQQQQQQQQ 343
                  :|:.::|                   |:.|:..|            ||
Mouse   487 SPGSVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHP----------- 540

  Fly   344 QNPQQNPQQNPQQTSSNQSQHVTSISISSPPSTPPEKPLIFQRGNYITTLVGGKPIELMGDDMAS 408
                 :||.:.||.....:|.|..:.              |.:..:..:|.|.|.:|
Mouse   541 -----DPQVSEQQLKEAVAQAVEGVK--------------FGKDRHQWSLEGVKRLE-------- 578

  Fly   409 TQTPPGHVTKTLIKENTHIDLRDRLSHMYSMPSKSLSASKISINSDSAYM--------------- 458
               ...|...||.||      |::.|   :.|.:......:..:|||:||
Mouse   579 ---SSWHGRPTLEKE------REKHS---APPHRRAQKIMVRSSSDSSYMSGSPGGSPCSAGAEP 631

  Fly   459 QHHRRDKERHR-----DRQHRERPRDPLQQQQQ-------LHRE-HLMSTHARSVEHLNHYNGLD 510
            |...|:...|.     ..:....|..|.:.||:       |.|| |......:|.|.|.......
Mouse   632 QPSEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRLKKSFEILVRKPTSS 696

  Fly   511 RRRDTPRQSESNTLRARLPSDMRSVKSLDFDSENESKPATETRTTRPTPPKKPLRLSLQRAQSLQ 575
            :.:..||:...|        |....|.|: :.|..:.|:..|..|.....::.|.|.||.    .
Mouse   697 KPKPPPRKYFKN--------DSEPQKKLE-EKEKVTDPSGHTLPTCSQETRELLPLLLQE----D 748

  Fly   576 TVELHPCADIERKRPMKRVHHNNNNNNKGGESPTGEGQTMLIENCSPMHTASLGRHKLI 634
            |....||.......|..        :.:...|..||.:    .:.||...||.|:|.|:
Mouse   749 TAGRAPCTAACCPGPAA--------STQTSSSTEGESR----RSASPETPASPGKHPLL 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	16/48 (33%)
Il16	NP_001347016.1	PDZ_signaling	316..391	CDD:238492	22/82 (27%)
		PDZ_signaling	454..536	CDD:238492	6/81 (7%)
		Atrophin-1	<620..931	CDD:331285	42/201 (21%)
		PDZ_signaling	1206..1283	CDD:238492
		PDZ_signaling	1328..1409	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900