DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sprt and TAMALIN

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_859062.1	Gene:	TAMALIN / 160622	HGNCID:	18707	Length:	395	Species:	Homo sapiens

Alignment Length:	356	Identity:	68/356 - (19%)
Similarity:	105/356 - (29%)	Gaps:	133/356 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ELRSALQDREAVIQNLRIQLCLGKLPRPTGPPL---DESEKPAAEQKLNRLKTEAENKRIKIKNL 150
            ||.:||:|.........:.:..|.|||..|...   :.|:.|..::|:..|:.| :|:
Human    54 ELYAALEDYHPAELYRALAVSGGTLPRRKGSGFRWKNLSQSPEQQRKVLTLEKE-DNQ------- 110

  Fly   151 KSALEKLDITDNIDIRIRQAELEYALGREELQMLSIVEEARALQARLEKSKPEAQTLYNIISSGV 215
                     |...:|:      .|.|...|.|.:.:|    ....|:.:|.| ||..
Human   111 ---------TFGFEIQ------TYGLHHREEQRVEMV----TFVCRVHESSP-AQLA-------- 147

  Fly   216 SLSLHAVHATSGRWAVQQRTDQPGFYVEWALEGDGLYKGDRILEINGRLVTGKSKEELQKQVGNS 280
                                              ||..||.|..:||..|.|....|:...:..|
Human   148 ----------------------------------GLTPGDTIASVNGLNVEGIRHREIVDIIKAS 178

  Fly   281 GKCQMVVLRKKSVPIPQKQLDQEKENNMRLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQ-- 343
            |.    |||.::       |.........|:.|:.||:      ||:.|.....:....|:|:
Human   179 GN----VLRLET-------LYGTSIRKAELEARLQYLK------QTLYEKWGEYRSLMVQEQRLV 226

  Fly   344 -----QNPQ-------------------------------QNPQQNPQQTSSNQSQ---HVTSIS 369
                 ::|.                               ..|:...::...:...   |.....
Human   227 HGLVVKDPSIYDTLESVRSCLYGAGLLPGSLPFGPLLAVPGRPRGGARRARGDADDAVYHTCFFG 291

  Fly   370 ISSPPSTPPEKP--LIFQRGNYITTLVGGKP 398
            .|.||:.||..|  ..|..|...|..||..|
Human   292 DSEPPALPPPPPPARAFGPGPAETPAVGPGP 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	12/40 (30%)
TAMALIN	NP_859062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PDZ_signaling	100..185	CDD:238492	31/158 (20%)
		Interaction with PSCD3. /evidence=ECO:0000250	181..258		14/89 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..349		12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900