DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and FRMPD2

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	403	Identity:	85/403 - (21%)
Similarity:	145/403 - (35%)	Gaps:	131/403 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SKELRSALQDREAVIQNLRIQLCLGKLPRPTGPPLDESE-----KPAAEQKLNRLKTEAENKRIK 146
            |..|.||||.|                    |..|.|.|     ..||||.|..|:.::.:   .
Human    14 SVTLASALQVR--------------------GEALSEEEIWSLLFLAAEQLLEDLRNDSSD---Y 55

  Fly   147 IKNLKSALEKLDITDNIDIRIRQAELEYA-LGREELQMLSIVEEARALQARLEKSKPEAQTLYNI 210
            :....|||  |....::..:.|.:.:|.| ....||           ||.:.|..:|:|..:: :
Human    56 VVCPWSAL--LSAAGSLSFQGRVSHIEAAPFKAPEL-----------LQGQSEDEQPDASQMH-V 106

  Fly   211 ISSGVSL------------------SLHAVHATSGRWAVQQRTDQP--GFYVEWALEGDGLYK-- 253
            .|.|::|                  .||::..|       ...|||  ...::..||...:::
Human   107 YSLGMTLYWSAGFHVPPHQPLQLCEPLHSILLT-------MCEDQPHRRCTLQSVLEACRVHEKE 164

  Fly   254 --------GDRILEINGRLVTGKSKEELQKQVGNSGKCQMVVLRKKSVPIPQKQLDQEKENNMRL 310
                    |..|..:.| ||.| :..|::|:         ||....||         ::..:..|
Human   165 VSVYPAPAGLHIRRLVG-LVLG-TISEVEKR---------VVEESSSV---------QQNRSYLL 209

  Fly   311 QHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQN-----------------PQQNPQQTS 358
            :.|:.....:....|..:..||.:..::..:.|.:|:.:                 |..:||...
Human   210 RKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQ 274

  Fly   359 SNQ---SQHVTSISISSPPSTPPEKPLIFQRGNYITTLVGGKP--IELMGDDMASTQTPPGHVTK 418
            :.:   |..|.|.:.||.|:||.::..:.:|..:      .:|  |.|.|:...:...|...|||
Human   275 AGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKF------SRPEFILLAGEAPMTLHLPGSVVTK 333

  Fly   419 TLIKENTHIDLRD 431
               |..:::.|||
Human   334 ---KGKSYLALRD 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	10/50 (20%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801	51/236 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302		11/35 (31%)
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008
		PDZ_signaling	773..857	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880
		PDZ	947..1034	CDD:214570
		PDZ	1078..1167	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900