DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sprt and Lnx2

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_542985.4	Gene:	Lnx2 / 140887	MGIID:	2155959	Length:	687	Species:	Mus musculus

Alignment Length:	517	Identity:	101/517 - (19%)
Similarity:	166/517 - (32%)	Gaps:	166/517 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PISAHHRAFAKQKSASMTILNPKGCGSAVKYSLHSTAETNQETASTTTTSTHCSTT--GRRR--- 69
            |.::|.|...:::..|.|....:|          .|..|..:...|....|.||.|  |.|.
Mouse   139 PGASHRRVDLERRKTSQTQTQIEG----------ETGSTVIDPPGTLPPETDCSGTVPGERNLTP 193

  Fly    70 -------KGGSLGGTLSSRSTRSESKELRSALQDREAVI-----QNLRIQLCLGKLPRPTGPPLD 122
                   :...|.......|..::|.:...:|.:.|...     .|..|||.:.        .:.
Mouse   194 ASLPVWTEEPGLDNPAFEESAAADSVQQPLSLPEGEITTIEIHRSNPYIQLGIS--------IVG 250

  Fly   123 ESEKPAAE---QKLNRLKTEAENKRIKIKNLKSALEKLDITDNIDIRIRQAELEYALGREELQML 184
            .:|.|...   |::.|....|.:.|:...:....:...||: |:.....:|.|.......:|.:|
Mouse   251 GNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYDIS-NVSHNHARAVLSQPCSTLQLTVL 314

  Fly   185 SIVEEARALQARLEKSKPE---AQTLYNIISSGVSLSLHAVHATSGRWAVQQRTDQPGFYVEWAL 246
            ..........:..:.|.|.   .|.|.:...|...|.:..|          :|||:||.::...|
Mouse   315 RERRFGSRANSHADGSAPRDEVFQVLLHKRDSTEQLGIKLV----------RRTDEPGVFILDLL 369

  Fly   247 EG-----DG-LYKGDRILEINGRLVTGKSKEELQKQVGNSGKCQMVVLRKKSVPIPQKQLDQEKE 305
            ||     || |...||:|.|||..:                        |...|....|:.|...
Mouse   370 EGGLAAQDGRLNSNDRVLAINGHDL------------------------KHGTPELAAQIIQASG 410

  Fly   306 NNMRLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSISI 370
            ..:.|               |:.  .|.:.|         |....::....:|||.:|
Mouse   411 ERVNL---------------TIA--RPGKPQ---------PSNGSREAGAHSSSNHAQ------- 442

  Fly   371 SSPPS--------------TPPEKPLIFQRGNYIT---TLVGGK-------PIELMGDDMASTQT 411
              |||              |..||.:..::..:.:   |:.||:       ||.:       |..
Mouse   443 --PPSHSRPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFV-------TSV 498

  Fly   412 PP-------GHVTKTLIKENTH-IDLRDRLSHMYSM---------PSKSLSASKISINSDSA 456
            ||       |.:.:..:..|.: |||.: |||..::         |:..|.|.::.|..::|
Mouse   499 PPHGCLARDGRIKRGDVLLNINGIDLTN-LSHSEAVAMLKASAASPAVILKALEVQIAEEAA 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	11/46 (24%)
Lnx2	NP_542985.4	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..175		6/39 (15%)
		NPXY motif	207..210		0/2 (0%)
		PDZ	229..315	CDD:214570	17/94 (18%)
		PDZ_signaling	336..418	CDD:238492	28/130 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..454		10/56 (18%)
		PDZ_signaling	463..539	CDD:238492	18/83 (22%)
		PDZ_signaling	596..680	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900