DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and Patj

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	103/508 - (20%)
Similarity:	176/508 - (34%)	Gaps:	163/508 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GGTLSSRSTRSESKELRSALQDREAVIQNLRIQLCLGKLPRPTGPPLDESEKPAAEQKLNRLKTE 139
            |..|.:.|.....:.::||......|:|:      |...||......::.:.|...|..|..:.:
  Rat  1138 GVDLQNASHAEAVEAIKSAGNPVVFVVQS------LSSTPRVIPSVNNKGKTPPQNQDQNTQEKK 1196

  Fly   140 AENK-------------RIKIKNLKSALEKLDITDNIDIRIRQAELEYALGREELQMLSIVEEAR 191
            |:..             |....:.:.:.|...:||. .||.|.|:|.   |.     |.|:|
  Rat  1197 AKRHGTAPPPMKLPPPYRAPSADTEESEEDSALTDK-KIRQRYADLP---GE-----LHIIE--- 1249

  Fly   192 ALQARLEKSKPEAQTLYNIISSGVSLSLHAVHATSGR---WAVQQRTDQPGFYVEWALEGDGLYK 253
                 |||.|           :|:.||| |.:....|   :.|....|.|.       ..||..:
  Rat  1250 -----LEKDK-----------NGLGLSL-AGNKDRSRMSIFVVGINPDGPA-------AADGRMR 1290

  Fly   254 -GDRILEINGRLVTGKSKEELQKQVGNS-GKCQMVVLRKKSV---------PIPQ---------- 297
             ||.:||||.:::.|:|.:.....:..: .:.::|.:|.:..         |:|.
  Rat  1291 VGDELLEINNQILYGRSHQNASAIIKTAPTRVKLVFIRNEDAVNQMAVAPFPVPSHSPSPVEDLG 1355

  Fly   298 --KQLDQEKENNM---RLQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQ--NPQQNPQ 355
              :.:..|:::::   .|..|.|...|.:  .|.|.:...::|::..:......:|  .|..:.|
  Rat  1356 GTEPVSSEEDSSVDAKPLPERESSKPEDL--TQAVDDSMVAEQEKASESPDSAARQMKQPGYSAQ 1418

  Fly   356 QTSSN-----------QSQH--------------VTSISISSPPSTPPEKP---LIFQ----RGN 388
            .:||:           ||.|              |....:|..|:|.|..|   :|.:    |..
  Rat  1419 VSSSSQEIPSAPAPLCQSTHADVTGSGNFQAPLSVDPAPLSVDPATCPIVPGQEMIIEISKGRSG 1483

  Fly   389 YITTLVGGKPIELMGDDMASTQTPPGHVTKTL-------------------------------IK 422
            ...::||||...|.|   .|..|..|...|.|                               |.
  Rat  1484 LGLSIVGGKDTPLPG---GSLPTKVGVWEKKLQEMMSQDAIVIHEVYEEGAAARDGRLWAGDQIL 1545

  Fly   423 ENTHIDLRDRLSHMYSMPSKSLSASKISINSDSAYMQHHRRDKERHRDRQHRE 475
            |...:|||.. ||..::.:...:..|:.:   ..|     ||:.::||.::.|
  Rat  1546 EVNGVDLRSS-SHEEAITALRQTPQKVRL---VIY-----RDEAQYRDEENLE 1589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	11/42 (26%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492
		CtpA	<391..>511	CDD:223864
		PDZ_signaling	572..636	CDD:238492
		PDZ	684..773	CDD:214570
		PDZ_signaling	1074..1165	CDD:238492	6/26 (23%)
		PDZ	1244..1329	CDD:214570	27/116 (23%)
		PDZ	1471..1578	CDD:214570	22/118 (19%)
		PDZ_signaling	1590..1670	CDD:238492	103/508 (20%)
		PDZ_signaling	1731..1816	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900