DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and PARD3B

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	661	Identity:	118/661 - (17%)
Similarity:	218/661 - (32%)	Gaps:	223/661 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KGGSLGGTLSSRSTRSESKELRSALQDREAVIQNLRIQLCLGKLPRPTGPPLDESEKPAAEQKLN 134
            |..:|.||.|..:..|.|      ||..::           .::||..|.|...|..|     |.
Human   337 KTANLTGTDSPETDASAS------LQQNKS-----------PRVPRLGGKPSSPSLSP-----LM 379

  Fly   135 RLKTEAENKRIKIKNLKSALEKLDIT----------------DNI--------DIRIRQAE--LE 173
            ...:....|:||| :||...|.|..|                .||        |.|::..:  ||
Human   380 GFGSNKNAKKIKI-DLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 443

  Fly   174 Y----ALGREELQMLSIV------EEARALQARLE--------KSKPEA---------QTLYNII 211
            .    ..||.:.::::::      |.|..:.||.|        |.:|:.         |..:.|.
Human   444 VNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIP 508

  Fly   212 -----SSGVSLSLHAVHATSGRWAVQQRTDQPGFYVEWALEGDGLYK------GDRILEINGRLV 265
                 |:|:.:||      .|..:.:..||. |.:::..:.|...:|      .|:::.:||..:
Human   509 LNDSGSAGLGVSL------KGNKSRETGTDL-GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 566

  Fly   266 TGKSKEELQKQVGNS--------GKCQMVVLRKKSVPIP----------------QKQLDQEKEN 306
            .|||..|..:.:..|        |..|:|:||:...|:.                |..:...:.|
Human   567 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRN 631

  Fly   307 NMRLQHRISYLEEQVRELQTVKEHHPSQQQQQQ---------QQQQQNPQQNPQ-------QNPQ 355
            :..:.|.:...               |.|.:|:         .:.:..|...|.       ::..
Human   632 DNSILHPLGTC---------------SPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYS 681

  Fly   356 QTSSNQS------QHVTSISISSPPSTPPEKPLIFQRGNYITTLVGGKPIELMGDDMASTQTPPG 414
            .:|...|      ||:...|::  |:..||.          ..|...|.::|:.|: :...:..|
Human   682 HSSGVDSAVYFPDQHINFRSVT--PARQPES----------INLKASKSMDLVPDE-SKVHSLAG 733

  Fly   415 HVTKTLIKENTHIDLRDRLSHMYSMPSKSLSASKISINSDSAYMQHHRRDKERHRDRQHRERPRD 479
            ..:::..|:              ..|:..|..|....:..:|..:..:.|...||.|.|..|.|.
Human   734 QKSESPSKD--------------FGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRG 784

  Fly   480 PLQQQQQLHREHLMSTHARSVEHLNHYNGLDRRRDTPRQSESNTLRARLPSDMRSVKSLDF---- 540
            ..:..:.                     .:|:..|.|.:.|::.|..:.....:...:.:.
Human   785 CNESFRA---------------------AIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQG 828

  Fly   541 -----DSENESKPATETRTTRPTPPKKPLRLSLQRAQSLQTVELHPCADIERKRPMK----RVHH 596
                 |.||:::...:|:.......|..|::..::.:...       .|.|||...|    .:..
Human   829 NSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEEN-------EDPERKIKKKGFGAMLRF 886

  Fly   597 NNNNNNKGGES 607
            .....:|||::
Human   887 GKKKEDKGGKA 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	13/54 (24%)
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873
		PDZ_signaling	209..296	CDD:238492
		PDZ_signaling	395..475	CDD:238492	14/79 (18%)
		PDZ_signaling	509..597	CDD:238492	21/94 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900