DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sprt and whrna

DIOPT Version :9

Sequence 1:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	696	Identity:	132/696 - (18%)
Similarity:	212/696 - (30%)	Gaps:	241/696 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KGGSLGG-----TLSSRSTRSESKELRSALQ---------DREAVIQNLRI-----QLCL----- 110
            :|||..|     :|....:.:|.:.||...|         ||......:::     :||:
Zfish   193 RGGSEHGVGIYVSLVEPGSLAEKEGLRMGDQIMKVNDKVFDRVTHADAVKVLKGSKKLCMSVRSV 257

  Fly   111 GKLP----------------RPTGPPLDESEKPAAEQKLNRLKTEAENKRIKIKNLKSALEKLDI 159
            |::|                |...||.|             |..|..:..::..|
Zfish   258 GRIPGGYITNHVYTWVDPQGRSVSPPPD-------------LLAEHRSATLRRSN---------- 299

  Fly   160 TDNIDIRIRQAELEYALGREELQMLSIVEEARALQARLEKSKPEAQTLYNIISSGVSLSLHAVHA 224
                           :.||..:|:|...:|     .::.....:.::|..:|..|...||
Zfish   300 ---------------SQGRSHMQLLQDGDE-----KKVNLVLDDGRSLGLMIRGGAEYSL----- 339

  Fly   225 TSGRWAVQQRTDQPGFYVEW-----ALEGDGLYKGDRILEINGRLVTG----------KSKEELQ 274
                          |.|:..     |.|..|:..||:|||:|||....          ||...|.
Zfish   340 --------------GIYITGVDRGSAAECGGIKVGDQILEVNGRSFLSIPHDEAVRVLKSSHHLM 390

  Fly   275 ---KQVGNSGKCQMVVLRKK------------SVPIPQKQLDQEKENNMR--------------- 309
               |.||.....:.||...|            |..:....|||....:.:
Zfish   391 MTVKDVGRLPHTRTVVGETKWIASSQISDSSASSSVTGISLDQGASTSAKGGFYKGVAGSQVTLS 455

  Fly   310 --LQHRISYLEEQVRELQTVKEHHPSQQQQQQQQQQQNPQQNPQQNPQQTSSNQSQHVTSISIS- 371
              :....:.||||.|.|.|..|.   |......|:.::.....:|.........:.|.....:|
Zfish   456 SLVNQSRAMLEEQARHLLTEPER---QTMGYYIQEYRDGHVGVEQLVMALFELFNTHAKFSLLSE 517

  Fly   372 -----SPPSTPPEKPLIFQRGNYITTLV----GGKPIE------LMGDDMASTQTPPGHVTKTLI 421
                 :|........|:.:|  .|..|.    ||...:      ...|.:||:..  ..:|.|.:
Zfish   518 VRGIVTPQDVEKFDGLVLRR--EIDALKARQGGGAGFQDSFSMVSYPDTLASSSA--SFMTNTTL 578

  Fly   422 KENTHIDLRDR------LSHMYSMPSKSLSASKISINSDSAYMQHHRRDKERHRDRQH--RERPR 478
            ....:..:.:.      |.|..::|..||.....:.:|..::........:|...|:.  .:||.
Zfish   579 SSARNDGVAENNGEQGSLEHSNALPDISLDEVHSTSDSPPSFKPPPPPGLQRRPSRKATLSKRPS 643

  Fly   479 DPLQQQQQLHREHLMSTHARSVEHLNHYNGLDRRRDTPR--QSESNTLRARLPSDMRSVKSLD-- 539
            .. ..|..|:......:|.|..:|          ...|:  .|...||:..:|:...||.|..
Zfish   644 SS-SSQSGLYFTAPSRSHTRESKH----------PKAPKAFMSPPGTLKIDVPASQLSVVSQHPI 697

  Fly   540 -----FDSENESKPATETRTTRPTP-------------------------PKKPLRLSLQRAQSL 574
                 ..|.|::|||   :::.|.|                         |.||...|....|..
Zfish   698 GPFPRVQSPNKAKPA---QSSSPIPPPAPNVPAPPGPPPPPPPPLPPPSCPDKPTPSSPASNQHF 759

  Fly   575 QTVELH-PCA--DIERKRPMKRVHHNNNNNNKGG--ESPTGEGQTM 615
            ..||:| |.|  |:...||:.:|        :||  ...:..|||:
Zfish   760 VMVEVHRPNAEPDVNEVRPLPQV--------RGGTLSQLSDSGQTL 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	17/53 (32%)
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822
		PDZ_signaling	174..255	CDD:238492	13/61 (21%)
		PDZ_signaling	314..394	CDD:238492	22/103 (21%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	16/83 (19%)
		PDZ_signaling	848..919	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900