Protein Alignment mthl13 and ADGRB2

DIOPT Version :10

• Sequence 1: NP_788325.2
• Gene: mthl13 / 246395
• FlyBaseID: FBgn0050018
• Length: 440
• Species: Drosophila melanogaster
• Sequence 2: NP_001351786.1
• Gene: ADGRB2 / 576
• HGNCID: 944
• Length: 1585
• Species: Homo sapiens
• Alignment Length: 209
• Identity: 38/209 - (18%)
• Similarity: 86/209 - (41%)
• Gaps: 35/209 - (16%)

  Fly   175 SIICYIIIFGIYL----FVKELRNDFGKCVMSCVFCLFL--DYLIWLMDELRLLD-DFCSLTGYI 232
            |.:..:.:..||.    |:|..|:     ::...|||.:  ..::.|:.:.|:|. ..|::|...
Human   943 SCMALLTLLAIYAAFWRFIKSERS-----IILLNFCLSILASNILILVGQSRVLSKGVCTMTAAF 1002

  Fly   233 MFFFDFANSVWFSIISYCIWKKITSVVSQEN----RDQFVFYSTFAYGISAIPLGIIISINQFWE 293
            :.||..::..|  :::.. |:...:|:.:..    |.:|:   ...:|:.|:.:.:.:...:...
Human  1003 LHFFFLSSFCW--VLTEA-WQSYLAVIGRMRTRLVRKRFL---CLGWGLPALVVAVSVGFTRTKG 1061

  Fly   294 EDLRKWNWLPLVGFSRCSVDDCKRSSWVYYFV-PYAIMCAINIIMFVLTIKHIMKTKRNLHNLTK 357
            .....:.||.|.|            ..:|.|| |.|::..:|:::.::....:|..........|
Human  1062 YGTSSYCWLSLEG------------GLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKK 1114

  Fly   358 RPDRNETCVTVNFL 371
            :...:|.|...:.|
Human  1115 QRAGSERCPWASLL 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl13	NP_788325.2	Mth_Ecto	<49..158	CDD:448329
		7tm_GPCRs	186..440	CDD:475119	36/198 (18%)
		TM helix 2	197..218	CDD:410628	4/22 (18%)
		TM helix 3	227..249	CDD:410628	4/21 (19%)
		TM helix 4	269..285	CDD:410628	2/15 (13%)
		TM helix 5	316..339	CDD:410628	6/23 (26%)
		TM helix 6	376..397	CDD:410628
		TM helix 7	402..431	CDD:410628
ADGRB2	NP_001351786.1	AGRB_N	38..230	CDD:465991
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..271
		TSP1	314..362	CDD:214559
		TSP1	367..417	CDD:214559
		TSP1	422..472	CDD:214559
		TSP1	478..528	CDD:214559
		HormR	531..595	CDD:214468
		GAIN	614..>769	CDD:465137
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..806
		GPS	870..923	CDD:197639
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	874..924
		7tmB2_BAI2	929..1219	CDD:320654	38/209 (18%)
		TM helix 1	931..956	CDD:320654	3/12 (25%)
		TM helix 2	966..988	CDD:320654	4/26 (15%)
		TM helix 3	997..1025	CDD:320654	5/30 (17%)
		TM helix 4	1035..1055	CDD:320654	4/22 (18%)
		TM helix 5	1073..1102	CDD:320654	7/40 (18%)
		TM helix 6	1149..1176	CDD:320654
		TM helix 7	1181..1206	CDD:320654
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1359..1385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1423..1454
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1498..1585