Protein Alignment mthl13 and Adgrg7

DIOPT Version :10

• Sequence 1: NP_788325.2
• Gene: mthl13 / 246395
• FlyBaseID: FBgn0050018
• Length: 440
• Species: Drosophila melanogaster
• Sequence 2: NP_001100568.1
• Gene: Adgrg7 / 304014
• RGDID: 1307217
• Length: 785
• Species: Rattus norvegicus
• Alignment Length: 514
• Identity: 94/514 - (18%)
• Similarity: 192/514 - (37%)
• Gaps: 126/514 - (24%)

  Fly    13 ILLQFQAVNTDS--------NKTEEDSCVKSDDDNSNDEDDLWHCIPICCPRKNMMANGG----- 64
            :.:|..:.|:||        .|...||.|.|:...:...|:|   .|.......::.|.|
  Rat   255 VAIQSVSRNSDSGPSVLFSVQKGSSDSLVSSETSINKTADEL---KPDGQTELQILLNTGGNKNS 316

  Fly    65 C--------------------SFKEHLFRTKLDLNIRLDDNSTEALYFN----NQTLLITS---- 101
            |                    .|.:.:..:|::.:.:..:|.:..:.||    .:...:.|
  Rat   317 CGFVVYQNHKLFQSKTFTATSDFSQKIISSKVNASEQEQNNVSVKMVFNPTYDKREFQLYSYACV 381

  Fly   102 FWDIDEMMGLRRD------EYTLYKNGTIYIHSDQS------IQTKEEYCFYPHQIYSDFPETIW 154
            :|:|     |::|      :.::..:|.:....:.:      :..|::|         .:|:::.
  Rat   382 YWNI-----LKKDWDTAGCQKSVNASGFLGCQCNHTTNFAVLMSFKKDY---------KYPKSLD 432

  Fly   155 IISHKFSSIESPG-----AFELASGSI-----------ICY-IIIFG-IYLFVKELRNDFGKCVM 201
            ::|:...::...|     .|::.:..|           :|. ::||. :::|..|..|...|...
  Rat   433 VLSNIGCALSIAGLAITILFQILTRKIRKTSVTWVLVSLCISMLIFNLLFVFGIENSNKNLKTSD 497

  Fly   202 SCVFCLFLDYLIWLMDELRLLDDFCSLTGYIMFFFDFANSVWFSIISYCIWKKITSVVSQENRDQ 266
            |.:.....:..|...|.:...:..|:....::.:|......|..:.:..::..:...:....|..
  Rat   498 SNINANPNENKIPETDTIETPNPSCTAIAALLHYFLLGTFTWNGLSATQLYFLLIRTMKPLPRHF 562

  Fly   267 FVFYSTFAYGISAIPLGIIISI-------NQFWEEDLRK----WNWLPLVGFSRCSVDDCKRSSW 320
            .|..|...:|:.||.:|:.|.|       ..:||.|.|:    |..:|       ..:|..||..
  Rat   563 IVIISLVGWGVPAIIVGVTIGIIYALSGNKSYWELDYRQEEICWLAVP-------KNNDFARSPL 620

  Fly   321 VYYFV-PYAIMCAINIIMFV-LTIKHIMKTKRNLHNLTKRPDRNETCVTVNFLNFELYLLFLRIS 383
            ::.|: |..|:...||.:|| :|:|.:.|..:||.:..|.....:...|            |.|:
  Rat   621 LWSFIMPVTIILITNIAIFVIITVKVLWKNNQNLTSTKKVSSLKKVLST------------LSIA 673

  Fly   384 GIMGVAWILIIFLLIEVNSTFWDIFGIIIQQIHYGFGIILFVLL-----IFKRSTHQLL 437
            .:.||.||....:||. |.....:|..|....:...|:.:|:|.     :|:....::|
  Rat   674 VVFGVTWIFAYAMLIN-NDDIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQNEASKIL 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl13	NP_788325.2	Mth_Ecto	<49..158	CDD:448329	18/153 (12%)
		7tm_GPCRs	186..440	CDD:475119	58/270 (21%)
		TM helix 2	197..218	CDD:410628	3/20 (15%)
		TM helix 3	227..249	CDD:410628	2/21 (10%)
		TM helix 4	269..285	CDD:410628	5/15 (33%)
		TM helix 5	316..339	CDD:410628	7/23 (30%)
		TM helix 6	376..397	CDD:410628	6/20 (30%)
		TM helix 7	402..431	CDD:410628	6/33 (18%)
Adgrg7	NP_001100568.1	GPS	378..418	CDD:460350	5/44 (11%)
		7tmB2_GPR128	428..727	CDD:320385	65/318 (20%)
		TM helix 1	430..455	CDD:320385	3/24 (13%)
		TM helix 2	465..487	CDD:320385	4/21 (19%)
		TM helix 3	523..550	CDD:320385	2/26 (8%)
		TM helix 4	563..583	CDD:320385	6/19 (32%)
		TM helix 5	617..647	CDD:320385	11/29 (38%)
		TM helix 6	661..688	CDD:320385	7/38 (18%)
		TM helix 7	695..720	CDD:320385	5/24 (21%)