Protein Alignment RNASEH1 and rnh1

DIOPT Version :10

• Sequence 1: NP_002927.2
• Gene: RNASEH1 / 246243
• HGNCID: 18466
• Length: 286
• Species: Homo sapiens
• Sequence 2: NP_477315.1
• Gene: rnh1 / 35746
• FlyBaseID: FBgn0023171
• Length: 333
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 108/308 - (35%)
• Similarity: 139/308 - (45%)
• Gaps: 54/308 - (17%)

Human    28 FYAVRRGRKTGVFLTWNECRAQVDRFPAARFKKFATEDEAWAFVR--KSASPE---VSEGHEN-- 85
            ||||..||::||:.:|.||..||..|..|::|||.|..||..||.  ||.:|:   |..|.|.
  Fly    18 FYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKAS 82

Human    86 --QHGQESEAKASKRLREPLDGDGHESAEPYAKHMKPSVEPAPPVSRDT---------------- 132
              ......|...:.:..:....:.|:.||.........||..|..|..:
  Fly    83 LASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLNAAMNEVEGDPKPSNSSNLPDILNRKRKGTTSG 147

Human   133 ------------------------FSYMGD---FVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPL 170
                                    |.:..|   :|:|||||.|..|||....||.|||:|..|.|
  Fly   148 DKRNKIPRHASQVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNGRAGACAGYGVYFGKNHQL 212

Human   171 NVGIRLPGRQTNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAG 235
            |....:.||.||...||.||..||:.|....|.||.:.|||.|.||.||.||.||||..||....
  Fly   213 NAAKPVEGRVTNNVGEIQAAIHAIKTALDLGIQKLCISTDSQFLINSITLWVAGWKKRDWKLKNN 277

Human   236 KEVINKEDFVALERLTQ--GMDIQWMHVPGHSGFIGNEEADRLAREGA 281
            :.|.|..||..|::|.|  .:.::|.:|..|.|..|||.||:|||:|:
  Fly   278 QPVKNVVDFKELDKLLQENNITVKWNYVEAHKGIEGNEMADKLARQGS 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNASEH1	NP_002927.2	Cauli_VI	28..70	CDD:460297	21/41 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..127		5/25 (20%)
		RNase_HI_eukaryote_like	141..282	CDD:260012	68/143 (48%)
rnh1	NP_477315.1	Cauli_VI	18..60	CDD:460297	21/41 (51%)
		RNase_HI_eukaryote_like	183..326	CDD:260012	68/143 (48%)