DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrit1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	277	Identity:	64/277 - (23%)
Similarity:	95/277 - (34%)	Gaps:	98/277 - (35%)

- Green bases have known domain annotations that are detailed below.

  Rat   254 PELRPGVTS--IISPLGSTVLLRCGATGIPGPEMSWRRANGRP--LNGT--VHQEVSSDGSSWTL 312
            |.:...:||  ||...|..|.|||.|.|.|.|.:.|:|.:|..  :|.|  || ::.:|.
  Fly   157 PNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVH-DLETDS----- 215

  Rat   313 LDLPVVSLFDSGDYICQAKNF-----------------------------LGASETLISLIVTEP 348
            |:|..:|....|.|:|.|.|.                             :|.:.||...|...|
  Fly   216 LELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANP 280

  Rat   349 QTSTEYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVPSIKE--ELPLQNFQ 411
             ||..|       |.|.         |::::.....:..|     |.|..||.|.  .|.:.|.|
  Fly   281 -TSLNY-------WTRE---------NDQMITESSKYKTE-----TIPGHPSYKATMRLTITNVQ 323

  Rat   412 MDVPGEF---SREPSEHQETQMVRSLKVVGDTYHSVSLVWKAP---QAGNTTAFSVLYAVFGQRD 470
            ....|.:   ::.|.              ||...::.|...:|   |...||.           .
  Fly   324 SSDYGNYKCVAKNPR--------------GDMDGNIKLYMSSPPTTQPPPTTT-----------T 363

  Rat   471 MRRMTVEAGKTSVTIEG 487
            :||.|..|.:  :.::|
  Fly   364 LRRTTTTAAE--IALDG 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..128
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>240	CDD:301599
		Ig	257..345	CDD:299845	32/122 (26%)
		IG_like	267..345	CDD:214653	28/110 (25%)
		FN3	431..501	CDD:214495	12/60 (20%)
		LRR 6	525..548
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653
		Ig	69..139	CDD:143165
		IG_like	165..249	CDD:214653	28/89 (31%)
		IGc2	172..237	CDD:197706	25/70 (36%)
		IG_like	267..348	CDD:214653	24/116 (21%)
		Ig	270..339	CDD:299845	21/104 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900