Protein Alignment SLC17A8 and DAL5

DIOPT Version :10

• Sequence 1: NP_647480.1
• Gene: SLC17A8 / 246213
• HGNCID: 20151
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_012686.3
• Gene: DAL5 / 853617
• SGDID: S000003913
• Length: 543
• Species: Saccharomyces cerevisiae
• Alignment Length: 459
• Identity: 88/459 - (19%)
• Similarity: 181/459 - (39%)
• Gaps: 90/459 - (19%)

Human    84 LGFCISFGIRCNL-GVAIVEMVNNSTVYVDG---KPEIQTAQFNWDPETVGLIHGSFFWGYIMTQ 144
            :.:|: |.:.|.| .|..::.::.|:..|.|   ..::...|::|       :..:|::||:...
Yeast    81 IDYCM-FPLMCILYAVQFMDKISTSSAAVMGLRTDLKMHGDQYSW-------VTSAFYFGYLFMN 137

Human   145 I-PGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWS 208
            : |..||..:.:......|...:...:.:.:.:|..|.|...:.:|:|.|..|.|..|....:.:
Yeast   138 LGPVQFIFQRTSHMSKMLAVFIVIWGMLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITA 202

Human   209 KWAPPLERSRLATTSFCGSYAGAVVAMPLA-GVLV---QYI--GWSSVFYIYGMFGIIWYMFWLL 267
            ::....|:....:..|..:..|:::...:| ||.:   .|.  ||.::|.|.|:..|...:...|
Yeast   203 QYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYIHQDSYAIKGWRTLFVITGVITIFIGILIFL 267

Human   268 QAYECPAAHPTISNEEKTYIETSI-----GEGANVVSLSKFSTPWKRFFTSLPVYAIIVA-NFCR 326
            ...:.|:....:|..||..:...|     |.|.:                .:..|.||.| ...|
Yeast   268 WIPDDPSKARFLSKREKLMVVQRIRSNQQGFGNH----------------EIKKYQIIEALKDVR 316

Human   327 SWTFYLLLISQP------AYFEEV-----FGFAISKVGLLSAVPHMVMTIV-VPIGGQLADYLRS 379
            :|.::|..:|..      :.|..:     ||:: ||..||..:|...:.:| .|:.|.||.|..:
Yeast   317 TWLYFLFTVSSNIPNGGISSFMSILLNSDFGYS-SKETLLMGLPTGAVELVGCPLFGILAVYAAN 380

Human   380 RQI----------LTTTAVRKIMNCG-GFGMEATLLLVVG------------------FSHTKGV 415
            ::|          :....:..|.:|. ||...:....:.|                  .:::.|.
Yeast   381 KKIPFWKYKLSWAIFAAVLALIASCMLGFATNSKKARLAGAYLWYISPVSFICVLSNISANSSGY 445

Human   416 AISFLVLAVGFSGFA---ISGFNVNHLDIAPRY--ASILMGISNGVGTLSGMVCPLIVGAMTRHK 475
            :..:.|.::....:|   ::|........||:|  |.:.|.:...|  :..::..|::..:..:|
Yeast   446 SKKWTVSSINLVAYAAANLAGPQTFIAKQAPKYHGAKVAMVVCYAV--MIVLLSILLIVNLRENK 508

Human   476 TREE 479
            .|::
Yeast   509 RRDK 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..61
		MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	88/459 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..589
DAL5	NP_012686.3	MFS_FEN2_like	80..496	CDD:340885	85/441 (19%)