DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GAS2L2 and Msp300

DIOPT Version :9

Sequence 1:NP_644814.1 Gene:GAS2L2 / 246176 HGNCID:24846 Length:880 Species:Homo sapiens
Sequence 2:NP_001188695.1 Gene:Msp300 / 3771968 FlyBaseID:FBgn0261836 Length:13540 Species:Drosophila melanogaster


Alignment Length:958 Identity:173/958 - (18%)
Similarity:290/958 - (30%) Gaps:394/958 - (41%)


- Green bases have known domain annotations that are detailed below.


Human    47 GLDIDAAN----FLQVLETGLVLCQHANVVTDAALAFLAEAP-AQAQKIPMPRVGVSCNGAAQPG 106
            |..:|:..    .||..||...:..:..|:          || :|||.|||           |||
  Fly 10020 GAVVDSTQPEGVILQEFETEPTIETYEEVI----------APGSQAQLIPM-----------QPG 10063

Human   107 TFQARDNVSNFIQWCRKEMGIQEVLMFETEDLVLRKNVKNVVLCLLELGRRAWRFGVAAPTLVQL 171
            ..|.:..:...:|...::: |::.          ||.:|.||                   ::..
  Fly 10064 DVQTQGTIRAVVQQVTRKV-IRKT----------RKIIKRVV-------------------IIDG 10098

Human   172 EEEIEEEVRRELALPPPDPSPPAPPRRQPCHFRNLDQMVQSLVSHCTCP-VQFSMVKVSEGKYRV 235
            :|.|.|||..|     |:.                    ..:....|.| :..::|:..:||. |
  Fly 10099 KEHITEEVVEE-----PEE--------------------VEITEEETAPHINVNIVRTVDGKV-V 10137

Human   236 GDSNTLIFIRILRNHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFL--------KPPAPPV 292
            .:..   |.|:::                               :||..:        ||.|.| 
  Fly 10138 SEEE---FQRMMQ-------------------------------EPGVLIEEVATDLQKPTAEP- 10167

Human   293 QHEV-------------------RVQDGP-SQTQPTMTISRSQSP---PPP---VDWKTYTSSDR 331
            |.||                   :.|:.| .|||||.|.:..::|   |.|   |:.....::..
  Fly 10168 QQEVFDIESTQVTTTTRTTTATTQEQEQPEQQTQPTTTETTKEAPVELPAPQVDVEQPVVVATTS 10232

Human   332 RLRPPTPSSPRPRRERGAGTGAS-----------REMAPFLRCQERSLIPS---WRQPTAGDSPP 382
            .:..||.....|:......|.|:           .|:.|.    |..|.|:   :.|.....:.|
  Fly 10233 PVHVPTADVVEPKDSSPTSTTAAVVDVEAVVEDINEIWPL----EHHLKPTNIDFSQHVEELAAP 10293

Human   383 SPQSSSTQKG--------RDPQCTSSGKREE-RYPPELPRGRIPTSWVHEETDSWGTDAGNPTPQ 438
            :..::.|:..        ..|:..:|...|: .:.|:.|         |||  |..:|...|   
  Fly 10294 AAVTAETEASMPVEEIWPTSPETGNSLTLEQYEFEPQSP---------HEE--STKSDLVKP--- 10344

Human   439 RLRAIEATTKGISARGPSPLPRSFGPAECLGLRLPLRDEAKGAFFQFREPESVRSPTPVQGLTKI 503
                                                         |..||:.|....|       
  Fly 10345 ---------------------------------------------QETEPQVVAETKP------- 10357

Human   504 PIRLPPARPPTPGRSFPGATSGSPRTELGRDPIPLRAVTVDLAGSTHGDCSVEVRQE-------- 560
                            .|.|:||         |.:...|..:..||      ||.:|        
  Fly 10358 ----------------EGITTGS---------ITITKTTTTITSST------EVPEETLVQNVPA 10391

Human   561 DQQ--------LDIQVMAEARESWDLGLQEQEGRYTPLPLGGNKEQAIYCSLEEEILGNMKLLEV 617
            |:|        .|||...||.::....|:||    :..|.|.:..:.:....||.:| ..:.:|:
  Fly 10392 DEQQPPANKIKTDIQSFLEAEQTLAAALKEQ----SSTPTGASVAEDVQTQPEEIVL-EERTVEI 10451

Human   618 RS-ACPQGTRSGVIPRSGVYIPRLAGQWPEPGGP-------------YDKAIQELAQGSPSLLKV 668
            .: ...:..:..||......:|    ..|||..|             .:|..:.:.:..|:...:
  Fly 10452 STIKTEENQQEPVIVEEVKSLP----VEPEPVEPELEEVAIAIVEQTEEKPEEPVIEKQPASGPI 10512

Human   669 DLEA-------WKAAPTGSPK-------PAVTP-GPGSLKGKLGARQSGPRTKASLSAKGTHMRK 718
            ||.|       .:||.:.:|:       |::.. |.|.||..||...:.....|:          
  Fly 10513 DLRAATQLFISGEAAASTAPQKTFQISAPSLEDNGAGVLKVVLGKESTNEEDTAA---------- 10567

Human   719 VPPQGGQDCSASTVSASPEAPTPSPLDPNSDKAKACLSKGRRTLR-----------KPKRVPSIY 772
             |..|....:....:|:|.|          |..:....|.||..:           :|:.|.::.
  Fly 10568 -PTTGKVSMTIIETAAAPAA----------DAKRRRKKKKRRDTKHEEELEQEQETEPEPVAAVK 10621

Human   773 KLKLRPRIRPRRDHRPEKQPSRIPRPLAYVFLGPARQ------PPKDRLLRAVLGSKGGEASR-- 829
            :    |.:.......||..|....|..:.|.:.|...      ..|.:::...:.|...|:.|  
  Fly 10622 E----PEVSSDVPVSPEDSPRDTVRHESIVEISPDSDLSSIEIDTKVKIVEDAVVSSPSESPRTP 10682

Human   830 ----------VDGASVGEEEE----------EGKEEKEPAAPLESSPQ 857
                      |:.|.|.:||:          |..|.::....:::|||
  Fly 10683 MVELVIPTEVVELALVEDEEQQTTPRIPSPTEKSEVEQDIKSVQTSPQ 10730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAS2L2NP_644814.1 CH 34..159 CDD:237981 26/116 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..200 2/19 (11%)
GAS2 207..274 CDD:280367 8/67 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 283..360 25/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..437 14/73 (19%)
Interaction with ADORA2A. /evidence=ECO:0000250|UniProtKB:Q5SSG4 438..880 87/504 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..533 6/43 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..880 42/229 (18%)
Msp300NP_001188695.1 SPEC 17..220 CDD:238103
SPEC 9546..9732 CDD:295325
sbcc 11187..12008 CDD:129705
SMC_prok_B 11614..12442 CDD:274008
SPEC 11994..12156 CDD:295325
SPEC 12374..12564 CDD:295325
Lipase_chap 12376..12529 CDD:281297
SPEC 12703..12923 CDD:238103
SPEC 12816..13032 CDD:295325
SPEC 13196..13374 CDD:238103
KASH 13484..13540 CDD:287506
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.