Protein Alignment Npr1 and Gyc76C

DIOPT Version :10

• Sequence 1: NP_036745.1
• Gene: Npr1 / 24603
• RGDID: 3195
• Length: 1057
• Species: Rattus norvegicus
• Sequence 2: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Alignment Length: 1139
• Identity: 410/1139 - (35%)
• Similarity: 600/1139 - (52%)
• Gaps: 176/1139 - (15%)

  Rat    14 LLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL 78
            ||||...:.....|.:.|||..:..||..........:..|:.:||..|...|:|||.
  Fly     9 LLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPN------- 66

  Rat    79 GSSENAAGVCSDTAAPLAAVDLKWEHSP------------------AVFLGP-GCVYSAAPVGRF 124
                             ..:||:|..:.                  |...|| |..|..|.|.:.
  Fly    67 -----------------VYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQS 114

  Rat   125 TAHWRVPLLTAGAPALGIGVKDEY---ALTT--RTGPSHVKLGDFVTALHRRLGWEHQALVLYAD 184
            .   .:|:::....        ||   |:.|  ||.|...::...:.||.|...| ::..:||.|
  Fly   115 R---NIPMISYKCA--------EYRASAIPTFARTEPPDTQVVKSLLALLRYYAW-NKFSILYED 167

  Rat   185 RLGDDRPCFFIVEGLYMRVRERLNITVNH-QEFVEG------------DPDHYPKLLRAVRRKGR 236
                   .:..|..|......:.|:|:|| |.|::.            ...::.:|::....:.|
  Fly   168 -------VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTR 225

  Rat   237 VIYICSSPDAFRNLMLLALNAGLTGE-DYVFFHLDVFGQSLKSAQGLVPQKPWERGD-----GQD 295
            :.....:.::..:.|.....|||... :|:...:|:...|.:.|     :|...|.|     ...
  Fly   226 IYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREA-----EKYLRRVDQITFMSNC 285

  Rat   296 RSARQAFQAAK--IITYKEPDNPEYLEFLKQLKLLADK-KFNFT-----VEDGLK---NIIPASF 349
            .|.....|.|:  ::....|...:|::|.||::..:.| .||..     ||....   :|..|..
  Fly   286 HSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYL 350

  Rat   350 HDGLLLYVQAVTETLAQGGTV----------TDGENITQR-MWNRSFQGVTG-YLKIDRNGDRDT 402
            :|.:.||..||.:.|.:...|          ::|..:... :.||::..:|| .:|||:.||.:.
  Fly   351 YDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEG 415

  Rat   403 DFSLWDMDPE--TGAFRVVLNYNGTSQELMAVS------EHKLY--------WPL-GYPPPDVPK 450
            :||:....|.  ..:..:..||:     ::.|:      ||..|        ||. |..|.|.|.
  Fly   416 NFSVLAYKPHKWNNSNNMPCNYH-----MVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPM 475

  Rat   451 CGFDNEDPACNQD--HFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQP 513
            |||.||  .|.:|  |: |..|.|:|..:.|....:::..||||.::|.|:...||::     .|
  Fly   476 CGFANE--LCKKDDTHY-TSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKI-----DP 532

  Rat   514 SSLE----RHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN--RKRIEL 572
            :.::    ..:.|:.|:::|.. ..:|||..|.    |....|...:|.:|.:|.:.  ||| ::
  Fly   533 NEIKGYSGNEIVSSPSKVSLMS-AQSYGSRWTN----QFVTSTGRLRGAVVRIKELKFPRKR-DI 591

  Rat   573 TRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTN 637
            :|:::.|::.:|:::::::..|:||..:|..|.::|:||.:|||.||:|||.|.||.:|..||.:
  Fly   592 SREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIH 656

  Rat   638 DIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQGHTLFAKKLWTA 699
            |::|||:::||..:..|||||||||||..|::|::||:||...|   :.|....|..:..:||.|
  Fly   657 DLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRA 721

  Rat   700 PELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERV----TRGEQPPFR 760
            |||||   ....|||.||||:|.||:.||..|.|.|  ..::..||||::.|    .:||. |||
  Fly   722 PELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGED-PFR 780

  Rat   761 PS----MDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYAN 821
            |.    ::.:|..:.:...::.||||||:|||.|..||..|:|.....:.||:|.::..||:|||
  Fly   781 PEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYAN 845

  Rat   822 NLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSA 886
            |||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.|||||||||||||:||
  Fly   846 NLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSA 910

  Rat   887 ESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDA 951
            ||||:|||..||||||.||.:|..:|||||||||||||||||||::||..||.|:|.|||.||.|
  Fly   911 ESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHA 975

  Rat   952 VRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET 1016
            |:..||.|||.|.|:||||:|||||.||||||.|||||||||||||||||||||||||||:|::.
  Fly   976 VKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKC 1040

  Rat  1017 KAVLEEF-DGFELELRGDVEMKGKGKVRTYWLLG 1049
            |..|::. .|:..|.||.|.|||||.|.|:||.|
  Fly  1041 KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:380608	99/488 (20%)
		PK_GC-A_B	530..803	CDD:270944	112/285 (39%)
		HNOBA	<809..857	CDD:462234	26/47 (55%)
		CYCc	836..1025	CDD:214485	132/189 (70%)
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	97/471 (21%)
		PK_GC-A_B	543..827	CDD:270944	115/295 (39%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	133/191 (70%)