Protein Alignment Npr1 and ACXE

DIOPT Version :9

• Sequence 1: NP_036745.1
• Gene: Npr1 / 24603
• RGDID: 3195
• Length: 1057
• Species: Rattus norvegicus
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1009
• Identity: 211/1009 - (20%)
• Similarity: 346/1009 - (34%)
• Gaps: 296/1009 - (29%)

  Rat   192 CFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPK---LLRAVRRKGRVIYICSSPDAFRNLMLL 253
            |..:| |::.||   :|.||....|:  |...|.|   .||..|.:.:.:
  Fly   209 CLNLV-GIFYRV---MNDTVVRSSFL--DRHQYIKEKIWLRNARLQEKQL--------------- 252

  Rat   254 ALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEY 318
             |::.|..:..:....|:.|:.:.:.||:......||..........:...|.::.|........
  Fly   253 -LDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQIHPDVSILYADVVNYTHLTTTLT 316

  Rat   319 LEFLKQLKLLAD-------KKFNFTVE------------DGLKNIIPASFHDGLLLYVQAVTETL 364
            :|.|  :|:|.|       ..:.:.|:            .||.:..|...::.::|.:..:...:
  Fly   317 VEML--VKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYCVAGLSDPDPDHANNCVILGLSMINHIM 379

  Rat   365 AQGGTVTD--GENITQRMWNRS---FQGVTGYLKIDRNGDRDTDFSLWDMD-------PETGAFR 417
                .|.|  |.:|..|:...|   |.||.|..|:        .|.:|.:|       ..||...
  Fly   380 ----EVRDIHGLDINMRIGVHSGNLFAGVIGEAKL--------QFDIWGLDVTIANVLESTGVPG 432

  Rat   418 VVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNED-PACNQDHFSTLEVLALVGSLSLIS 481
            .|.....|...|                 ||.:  ||.|| |...:||            ..|..
  Fly   433 CVHISGATLNNL-----------------DVNR--FDIEDGPEEARDH------------PLLKK 466

  Rat   482 FLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQF 546
            :.|.|:.|.:.:.::.|...|.    ..||...|    |.:.|::..:|...:.....|..|...
  Fly   467 YRIRSYIIRQDLHMDDEDSDEF----LGDLHSIS----LCNMGAQPRISDSANQSLRALFHEELR 523

  Rat   547 QVFAK---TAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILT 608
            :.|.|   :|:....|:.:.|.|..            |.:...||             .||| ||
  Fly   524 EEFRKMPVSAFSPKRLLGICRFNTG------------KEVPAHQN-------------LNIC-LT 562

  Rat   609 EYCPRGSLQDILENESI-TLDWMFRYSLTNDIVKGMLFLH-----NGAICSHGNLKSSNCVVDGR 667
            ...|      |||...: ..|:|::||:......|...::     ...||       |:|.|...
  Fly   563 FTDP------ILERAYLKQTDYMYKYSIILSASVGCSLVYIELMDTQMIC-------SSCFVLPA 614

  Rat   668 FVLKI---------------TDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGD 717
            .|..|               |.||..:.  |....|.:.|..::  ..::|.  |.|.|..
  Fly   615 SVATIQCILALIAWYKKYCWTRYGRNNV--PHHYNGFSCFIFRI--HDKILN--SLPIRIC---- 669

  Rat   718 VYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPP---FRPSMDLQ------------S 767
            :|.|.:|.....:...|...:..:.....|.||:...||..   |.|.:...            :
  Fly   670 IYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEAHICFHPWVTTNMLSLMICLTFTFA 734

  Rat   768 H-----------LEELGQLM----------QRCWAEDPQERPPFQQIRLA----LRKFNKENSSN 807
            |           ||.|..|:          ......:|..:..:....|.    |..|.||
  Fly   735 HIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYAHALLICITFLIMFVKE---- 795

  Rat   808 ILDNLLSRMEQYANNLE-----ELVEERTQAYLEEKRKAEALLYQILPHSVAE----QLKRGETV 863
                   |..::.|.:.     :|.:|...|.| .......:|..|||..:.:    .|.:.| :
  Fly   796 -------RQIEFTNKVNFNWRVDLRKEENAASL-TNHSIIIILNNILPSHIVDVYLNSLAKHE-L 851

  Rat   864 QAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVI----DNFDVYKVETIGDAYM 924
            ..|.:..|::.|:.::.|      ...::.:.:||::...||.::    :.:.|.|::.:|..||
  Fly   852 YFENYRMVSVMFAMLINF------EMDLRSLRVLNEIIAEFDTLLLFYKEYYTVEKIKIVGCTYM 910

  Rat   925 VVSGL-----------------PVRNGQLHARE-------------VARMALALLDAVRSFRIRH 959
            ...||                 |....:..:|.             |..|....||.:|:....:
  Fly   911 AACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYALDMMRTLAKSN 975

  Rat   960 RPQEQL---------RLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSE 1015
            ...:.:         .:.|||.:|.|.||:||...|.|.::|:.||.||||||.|....||::.|
  Fly   976 EAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTEE 1040

  Rat  1016 TKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLG 1049
            |..:|::| |.....||...:||:||:.|| |:|
  Fly  1041 TSEILQQF-GITCSYRGMTFVKGRGKIPTY-LVG 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	54/280 (19%)
		ANF_receptor	50..410	CDD:279440	48/244 (20%)
		PK_GC-A_B	530..803	CDD:270944	63/336 (19%)
		TyrKc	543..797	CDD:197581	59/317 (19%)
		HNOBA	<812..857	CDD:285003	10/53 (19%)
		CYCc	836..1025	CDD:214485	55/235 (23%)
		Guanylate_cyc	863..1049	CDD:278633	59/228 (26%)
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	18/84 (21%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	38/201 (19%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	58/227 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900