DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npr1 and Gycbeta100B

DIOPT Version :9

Sequence 1:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus
Sequence 2:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	189/721 - (26%)
Similarity:	286/721 - (39%)	Gaps:	227/721 - (31%)

- Green bases have known domain annotations that are detailed below.

  Rat   538 SLLTTEGQF---QVFAKTAYYKGNLV--AVKRVNRKR---IELTRKVLFE--------------- 579
            ::::.||||   |::.....|  ||:  ||:.:|...   :||..|..||
  Fly    29 AMVSMEGQFLVRQIYDDEITY--NLIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLG 91

  Rat   580 ------LKHMRDVQNEHL-TRFVG------ACTDPPNICILTEYCPRGSLQDI-----------L 620
                  |::: |..::|| |.:.|      .||:.....:|..|..|..|:.|           |
  Fly    92 ATPRDFLQNL-DALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSERPGLEHIVIGIVKAVASKL 155

  Rat   621 ENESITLDWMFR------------------YSLTNDIV------KGMLFL-----------HNGA 650
            ....:.:|.:.|                  ..|..|.|      ...:.|           |||:
  Fly   156 HGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGS 220

  Rat   651 -------ICSHGNLKSSNCVVDGRFVLKITDYGL---------ESFR-DPEPEQGHTLFAKKLWT 698
                   :.::||..:.|...||:.:...||..:         :||. |.:.||
  Fly   221 NGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQ----------- 274

  Rat   699 APELLRMASPPARGSQAGDVYSFGIILQEIALRSGV------------FYVEGLDLSPKEIIERV 751
              :.||:....:...:..|...|.|....:|.:|.|            |..|...:||      .
  Fly   275 --KCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISP------A 331

  Rat   752 TRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDN----- 811
            |..:..||....|.|..:.:.|:.:.|......:|.....::..|:|...:.|..|||.:
  Fly   332 TFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIY 396

  Rat   812 --------LLSRMEQ-------------------------------------------------- 818
                    :.||.||
  Fly   397 VLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARD 461

  Rat   819 -------------YANNLEELVEERTQAYLE---EKRKAEALLYQILPHSVAEQLKRGETVQAEA 867
                         ...|||.|.::..|.:.:   ||:|.:.|||.:||.|||.:|:....|..:.
  Fly   462 LVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKR 526

  Rat   868 FDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVID---NFDVYKVETIGDAYMV 925
            :||||:.||.||||....|.:|    .|::|.:||:|||.|||:.|   |.:||||||:||.||.
  Fly   527 YDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMA 591

  Rat   926 VSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCL 990
            ||||| .:.:.||:.:||:||.::|..::.::...|   :::.||||:|.|..||:|.::|||||
  Fly   592 VSGLP-DHCEDHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVTGVIGNRVPRYCL 652

  Rat   991 FGDTVNTASRMESNGEALKIHLSSETKAVL----EEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051
            ||:|||..||.|:.|...:|::|.||..:|    .:.|.|.||.||.|.||||......|.|...
  Fly   653 FGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRA 717

  Rat  1052 GCSTRG 1057
            ..|..|
  Fly   718 TSSILG 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944	73/375 (19%)
		TyrKc	543..797	CDD:197581	71/364 (20%)
		HNOBA	<812..857	CDD:285003	20/110 (18%)
		CYCc	836..1025	CDD:214485	88/202 (44%)
		Guanylate_cyc	863..1049	CDD:278633	88/196 (45%)
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	30/137 (22%)
		HNOBA	326..516	CDD:285003	36/195 (18%)
		CYCc	496..688	CDD:214485	88/195 (45%)
		Guanylate_cyc	522..714	CDD:278633	88/195 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810