Protein Alignment Npr1 and Gyc89Db

DIOPT Version :9

• Sequence 1: NP_036745.1
• Gene: Npr1 / 24603
• RGDID: 3195
• Length: 1057
• Species: Rattus norvegicus
• Sequence 2: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 163/593 - (27%)
• Similarity: 262/593 - (44%)
• Gaps: 136/593 - (22%)

  Rat   530 SGRG--SNY--GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFEL-KHMRDVQN- 588
            |||.  |.|  |.:.....:|.....|||...:...:.......|:||...|..: |:..|..|
  Fly   135 SGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLDFDNR 199

  Rat   589 EHLTRFVGACTDPPNICILTEYCPRGSLQDILE--NESITLDWMFRYSLTNDIVKGMLFLHNGA- 650
            :::.:.|.....|..:.:     |...|...||  ..:|.||...:.:|..:.:.....|||..
  Fly   200 DYMAKRVNVIAHPSQLKM-----PSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGV 259

  Rat   651 -----ICSHGNLKSSNC------------VVDGRFVL----------------KITDYGLESFRD 682
                 |.|| .|:...|            ::..|.||                ...::..|:|.:
  Fly   260 NPKTFIGSH-ILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDE 323

  Rat   683 P---EPEQGHTLFAKKLWTAPELLRMAS---------PPARGSQAGDVYSFGIILQEIALRSGVF 735
            .   ...|...|.:.|.::|......|:         .||.|.:.   :|.|  |:.|.|:..:|
  Fly   324 ASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRR---HSVG--LRSILLKGQMF 383

  Rat   736 YVEGLD-----LSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRL 795
            |::.:|     .||  :||                  :|:||                  ..|.|
  Fly   384 YIKDVDSLIFLCSP--LIE------------------NLDEL------------------HGIGL 410

  Rat   796 ALRKFNKENSS-----------NILDNLLSRMEQYANNLEELVEERTQAYLEE--KRKAEALLYQ 847
            .|...|....|           :.|:.:..:.||.::.||:.:|      |.:  ||:.:.|||.
  Fly   411 YLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLE------LADSWKRQGDELLYS 469

  Rat   848 ILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDN 910
            ::|..:||::::.|....::|:.|::.|.:::......:.:  ..||.||.||.:::..|..|.:
  Fly   470 MIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIIS 534

  Rat   911 FDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGP 975
            ..||||||:|..||.|||.|..| .|||.....:||.::..|::..:     ..:.:|:||::||
  Fly   535 PFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKVKAHAL-----PGVAIRVGINSGP 593

  Rat   976 VCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKG 1040
            |.|||||:|:||||||||||||||||||:.:...|.||:.|...:::. |:::|.||.|::||||
  Fly   594 VVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKV-GYKVEARGFVKVKGKG 657

  Rat  1041 KVRTYWLL 1048
            ::.|||||
  Fly   658 EMETYWLL 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944	67/331 (20%)
		TyrKc	543..797	CDD:197581	59/308 (19%)
		HNOBA	<812..857	CDD:285003	14/46 (30%)
		CYCc	836..1025	CDD:214485	74/192 (39%)
		Guanylate_cyc	863..1049	CDD:278633	79/188 (42%)
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	7/25 (28%)
		HNOBA	218..479	CDD:400168	64/310 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	77/183 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810